Title: Effect of Canthaxanthin on the Lipid Levels of Hyperlipidemia Rat
Abstract: To observe the effect of canthaxanthin on the lipid level of SD rat by high fat feed,60 SD male rats were randomized into six groups with 10 rats in each group.They were individually housed in metal cages in an air-conditioned room.Throughout the experimental period,they were given restricted amounts of food(40~50 g/d)per diet,with no limit of drinking.The control group was fed with standard diet.The hyperlipidemia model group was fed with standard diet containing cholesterol.The canthaxanthin group was fed with standard diet containing cholesterol plus simvastatin.All the rats were fed for twelve weeks.Blood samples were drawn just before the experiment and at the fourth,the eighth,the twelveth weekend of the experiment.The blood samples were analyzed for total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)and measured enzymatically by automatic facilities.Compared with the hyperlipidemia model group,the TC,TG and LDL-C level was lower markedly by dietary canthaxanthin at the twelveth weekend(P0.01),but HDL-C level was higher than the hyperlipidemia model.Canthaxanthin may effect the lipid level of rat by high fat feed.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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