Title: Clinical Research on the Expressin of BRMS1 and the Micro-metastasis of Axillary Lymph Node in Breast Cancer
Abstract: Objective: To investigate micro-metastasis in axillary lymph nodes and its relationship with BRMS1 genes expressin of the tumor tissue in breast cancer.Methods: Identifying the micro-metastases situation of the lymph node by serial sectioning and the expression of CK-19 in 89 cases of breast cancer tissue with lymph node metastasis-negative confirmed by conventional pathological findings,the postoperative follow-up was performed for 16 to 80 months.At the same time,detected the expression of BRMS1 protein by immunohistochemistry and analyzed its relationship with lymph node micrometastasis and recurrence rate.Results: There were 48(6.97%) detected micrometastases among the 689 lymph node from 86 cases of breast cancer axillary lymph node metastasis.22 cases(25.58%) were positive,BRMS1 expression-negative breast cancer patients with axillary lymph node micrometastases in cases(43.24%) and recurrence rate(54.05%) is much higher than BRMS1 expression-positive breast cancer patients(12.24%,8.16%),the difference was significant,and there was a significant negative correlation.Conclusion: The expressin of BRMS1 is Closely related to axillary lymph nodes Micro-metastases in breast cancer,BRMS1 can become a molecular indicator of breast cancer's axillary lymph node micro-metastases,and it is great significance to breast cancer staging,prognosis,and treatment.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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