Title: The protective effect of magnolol on cerebral ischemia
Abstract: AIM To study the protective effect of magnolol (Mag) on cerebral ischemia. METHODS Anoxia was produced by close normobaric hypoxia; acute incomplete cerebral ischemia was induced by ligaturing bilateral carotid arterise; the local cerebral ischemia was made by middle cerebral artery occlusion. Superoxide dismutase (SOD), malondialdehyde (MDA) and lactate dehydrogenase (LDH) were meassured. The extent of neurologic deficit and the pathological change of cerebral tissues were observed. RESULTS Mag, in a dose dependent manner, prolonged survival time of mice in the states of anoxia and ligaturing bilateral carotid arterise. In the MCAO model, Mag markedly ameliorated rat neurologic deficit. It could also increase the activities of SOD and LDH, reduce MDA and water contents, dwindle infarct zone in cerebral tissues. The pathological examination showed that Mag could significantly protect brain from ischemia reperfusion injury, reduce the necrosis of neuron and the cerebral infarction silte. CONCLUSIONS Mag has a protective effect against ischemia brain damage by its antioxidant activity.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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