Title: Correlation of adiponectin,inflammatory factors with severity of coronary artery disease in patients with CHD
Abstract: Objective The aim of this study was to explore the correlation of adiponectin, inflammatory factors with severity of coronary artery disease in patients with coronary heart disease (CHD).Methods 85 CHD patients definitely diagnosed by coronary angiography (CAG) were included. The complexity of coronary artery lesion was evaluated by the numbers of suffered coronary branches and Gensini score. The CHD patients were further divided into subgroups according to the number of suffered coronary branches and Gensini score. 20 subjects without CAD diagnosed by CAG were enrolled into control group.Fasting plasma glucose (FPG), lipids (TC, TG, LDL-C and HDL-C), body mass index (BMI), serum adiponectin (APN), high sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) were all measured.Results The serum adiponectin level in CHD patients was significantly lower than that in control group, but hs-CRP, TNF-α levels were markedly higher than that in control group. There was significantly negative correlation between plasma adiponectin and each of the levels of hs-CRP, TNF-α and IL-1β(P0.05).Conclusion The decreased plasma adiponectin level might be associated with the occurrence and severity of coronary atherosclerosis and the unstability of plaque. The plasma adiponectin may antagonize the inflammatory factors and relieve the lesion of coronary artery, which contributes to the prevention of atherosclerosis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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