Title: Influencing of resveratrol on liver of rat with insulin resistance
Abstract: Objective:To study the effects of resveratrol on the liver of rat with insulin resistance.Methods:A total of 30SD male rats were randomly divided into standard diet group(the NC group),high fat diet group(the HF group)and resveratrol treatment group(the HR group)with 10rats in each groupThe control group was feed with the standard diet,the other two groups were feed with the high-fat diet,and the resveratrol group was given with resveratrol from the 8th weeks.All rats had high insulinnormal glucose clamps after 16weeks,and then were sacrificed.Condition of insulin resistance and the expression of IL-6,TNF-αin rats were observed.Results:Comparing with NC group rats,blood glucose and insulin levels of the HF group rats were increased significantly,while the GIR was decreased significantly after 16weeks(P0.05),which indicated successful insulin resistance rats model.There were significant differences in blood glucose,insulin levels,IL-6and TNF-αamong three groups(P0.05),and the level showed that HF groupthe HR groupthe NC group.Conclusions:Resveratrol can effectively reduce the blood glucose and insulin levels of rats with insulin resistance,it may adjust the level of IL-6and TNF-α.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot