Title: Effect of Metoprolol on carotid stherosclerosis in patients with essential hypertension
Abstract: Objective To explore the effect of metoprolol on carotid atherosclerosis.Methods Seventy patients of essential hypertensive were randomly divided into control group ( n=35 ) and treatment group ( n=35, metoprolol 25 ~ 50 mg/d ), for twelve weeks continuously.Serum levels of total cholesterol ( TC ) triglycerides ( TG ), low-density lipoprotein holesterol ( LDL-C ), high-density lipo-protein cholesterol ( HDL-C ) and C-reactive protein were determined for both groups before and after treatment.Carotid intima-medial thickness (IMT ) was measured by ultrasound.The incidence of carotid plaque and carotid plaque scores were calculated.Results After the treatment of 12 weeks, CRP, IMT, the incidence of carotid plaque and carotid plaque scores were all significantly reduced ( P< 0.05 ).The reduction of CRP, IMT, incidence of carotid plaque and carotid plaque scores were significantly bigger in treatment group than those in control group ( P< 0.05 ).Conclusions Metoprolol can retard the progressive development of carotid atherosclerosis and the carotid artery plaque can be regressed.
Key words:
Metoprolol; Essential hypertension; Carotid atherosclerosis
Publication Year: 2010
Publication Date: 2010-01-15
Language: en
Type: article
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