Title: Significance of serum PSA,PSAD in diagnosis and prognosis in patients with prostatic adenocarcinoma
Abstract: Objective: To evaluate the diagnosis and prognosis value of serum prostate specific antigen(PSA) and prostate specific antigen density(PSAD) in patients with prostatic adenocarcinoma.Methods: Both 28 patients with prostatic adenocarcinoma and 81 patients with benign prostate hyperplasia(BPH) were determined by pathological examination.PSA and PSAD levels in patients with prostatic adenocarcinoma were compared with that in patients with BPH.The relationships between PSA levels and clinical stages,pathological grades in patients with prostatic adenocarcinoma were evaluated.Results: (1) PSA and PSAD levels in patients with prostatic adenocarcinoma were higher than that in patients with BPH(P0.01).(2)when PSA level was of 4ng/ml or greater,the sensitivity,specificity and positive predictive value of PSA was 89.29%,59.29% and 43.10% respectively as a method to detect prostatic adenocarcinoma.When PSAD level was 0.15 or greater,the sensitivity,specificity and positive predictive value of PSAD was 81.82%,80.85% and 66.67% respectively as a method to detect prostatic adenocarcinoma.(3) PSA level was no difference between A and B stage and C to D stage in patients with prostatic adenocarcinoma.PSA level was no difference between Gleason scores less than 7 and Gleason scores 7 or greater.Conclusions: Both PAS and PASD have good values to detect prostatic adenocarcinoma and PASD may be better.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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