Title: clinical study On the effects of long program on letrozole ovulation induction in polycystic ovary syndrome
Abstract: Objective Discuss taking letrozole(LE) on two different days with polycystic ovary syndrome(PCOS) women with infertility of the effect of ovulation induction.Methods 96 cases of ovulation induction in infertile PCOS women,divided into 2 groups,A group of 56 patients: In the menstrual cycle,the third to seven days,daily oral letrozole 5mg,B group,40 patients: The third to ninth day in the menstrual cycle,daily oral letrozole 5mg.The tenth day of the menstrual cycle monitoring of follicular development,If the average diameter of dominant follicle 11 mm,the addition of HMG,starting from 75 IU once daily intramuscular injection,monitored every two to three days once a follicle,according to follicle growth,gradually increase the amount to 150IU per day with the maximum amount;When the dominant follicle diameter ≥ 18 mm or a positive urinary LH,intramuscular injection HCG5000-10000 IU,induce ovulation,tell the patient sexual intercourse at the injection day or the next day;Or 24h or 36h after the HCG injection for IUI(intrauterine insemination,IUI).To compare the two groups a variety of clinical indicators.Results Ovulation induction in both groups,Significant difference was found between two groups in HMG doses,the number of days required for follicular maturation,thickness of endometrium in the HCG days(P0.01).No significant difference was found between two groups follicle number of follicles ≥ 15mm in diameter in the HCG day,the positive rate of endmetrial development,pregnancy rate(P0.05),No significant difference was found between two groups in Ovarian hyperstimulation syndrome(OHSS),Both groups didn't have luteinizing unruptured follicle syndrome(LUFS).Conclusion The 5mg × 7d program has reduced HMG dosage and the number of days required for follicular maturation advantage.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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