Title: Gene diagnoses of Y-chromosome AZF microdeletion in primary spermatogenesis impairment
Abstract:Objective To evaluate the relationship between Y chromosome microdeletion and male azoospermia.Methods Multiplex PCR was used to detect Y chromosome microdeletion in 51 azoospermia patients and 7 heal...Objective To evaluate the relationship between Y chromosome microdeletion and male azoospermia.Methods Multiplex PCR was used to detect Y chromosome microdeletion in 51 azoospermia patients and 7 healthy controls.Results Y chromosome microdeletion was found in 11 (21.6%) of 51 azoospermia patients.Among the cases, 1 (2.0%) deletions were in sY86 (AZFa), 1 (2.0%) deletions were in sY127 (AZFb) ,1 (2.0%) deletions were in sY134 (AZFb), 1 (2.0%) deletions were in both sY127 and sY134,1 (2.0%) deletions were in sY254 (AZFc) and 4 (8.0%) deletions were in both sY254 and sY255. No microdeletion was found in 7 controls.Conclusion Y chromosome microdeletion might be closely related to azoospermia.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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