Title: Research of sentinel lymph node mapping in colorectal cancer
Abstract: [Objective] To discuss if sentinel lymph node(SLN)mapping technique could be used to identify SLNs in colorectal cancer and to forecast the metastases of sentinel lymph nodes.[Methods] By injecting subserosally the lymphazurin around the tumor without injecting into the lumen,the clinical research to sentinel lymph nodes in the surgical operation had been performed on 43 patients suffered from the colorectal cancer,where the fast-frozen pathology of sentinel lymph nodes was compared to the general wax pathology after the surgery to observe the relativity between sentinel lymph node metastases of fast-frozen pathology and the mesenteric lymph node metastases of general wax pathology,as well as its forecast value on the mesenteric lymph node metastases.[Results] SLN was successfully identified in 42 of 43 patients,with a biopsy rate of 97.7%.In 42 patients,there were 142 lymph nodes examined,of which 35 nodes were identified as SLNs.Compared the frozen pathology result of sentinel lymph node with that of general pathology,15 cases of 42 patients suffered from colorectal cancer were identified positive for the metastases of lymph nodes,and 13 patients were positive for metastases of sentinel lymph nodes;of which,9 cases of 13 patients were positive for the metastases of non-SLNs and the rest 4 cases were negative for the metastases of non-SLNs;there were 29 patients negative for non-SLNs metastases,of which,27 patients were negative for metastases of sentinel lymph nodes and the rest 2 cases were positive for the metastases of non-sentinel lymph nodes.The specificity was 100%(27/27),and sensitivity was 86.7%(13/15),false negative rate was 13.3%(2/15).[Conclusions] The SLN mapping in colorectal cancer plays an important role in the metastases of the lymph nodes,and can be used to direct the clinical surgery.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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