Title: Protection of L-carnitine on Renal Ischemic Reperfusion Injury in Rats
Abstract: Objective To investigate possible mechanisms involoved in the protection of L-carnitine against renal ischemic reperfusion injury in rat models.Methods Models of renal ischemia-reperfusion were established,and rats were divided into control and L-carnitine treated groups(each with n=24).Within each group,rats were further divided into four subgroups,Sham,1h,6h and 12h IR treatment.The levels of blood serum urea nitrogen(Bun)and creatinine(Scr),the activities of superoxide dismutase(SOD)and the content of malonaldehyde(MDA)in nephridial tissue were measureed.Histopathological damages were monitored accordingly.Results In the control group,Scr and Bun levels of the IR6h group and those of the sham operation group showed difference of statistical significance(P0.05 and P0.01 respectively).Furthermore,in the L-carnitine treatment group,the levels of Bun 12h after reperfusion and those of Scr 6 hours after reperfusion were markedly higher than those of the sham group(P0.05,P0.05,and P0.01 respectively),though lower than those of the control group(each P0.01)at the same reperfusion time points.In L-carnitine treatment group,the activity of SOD was apparently higher and the content of MDA was lower than those in control group(each P0.01).In addition,renal histological injuries were attenuated after L-carnitine administration.Conclusion L-carnitine protects kidney against ischemia after acute renal ischemia reperfusion injury through increasing SOD activity while inhibiting peroxidation in kidney,which may in turn be protective against renal damages by free radicals.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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