Title: A survey of the drug resistance in Clinical isolates of Mycobacterium tuberculosis and the epidemic trend of multidrug-resistant tuberculosis
Abstract: Objective To investigate the drug resistance in clinical isolates from the initially treated cases and the relapse cases and to evaluate the prevalent trend in drug-resistant tuberculosis.Methods The susceptibility assays of 8 drugs in 287 clinical isolates of M.tuberculosis(56 strains of those were isolated from initially treated cases) were performed by proporation method using Kuangs,agar medium.Results The rate of high resistant strains to isoniazid,rifampin,streptomycin,pyrazinamide were 1.8%,3.6%,17.9%,0.0%.in initially treated cases and 74.9%,58.0%,68.4%,32.0%,in relapse cases,respectively,and there were statistic significances between each drug(P0.001).The multidrug-resistance(MDR) strains in relapse cases occurred in a rate of 63.2% and the extensive drug resistance(XDR) strains in a rate of 10%.18% of MDR strains was XDR strains.No XDR strain was found in initially treated Cases and the rate of MDR strains was 1.8%.Conclusion A high rates of hospitaliged patients were infected by MDR and XDR Strains of M.tuberculosis and those MDR bacilli were originated in acquired drug resistance.DOT s Should be still the emphasis of measures in prevention and control of drug-resistant tuberculosis.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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