Title: Expression of Matrix Metalloproteinase-2 and Its Relationship with Angiogenesis in Lung Cancer
Abstract: To investigate the expression of matrix metalloproteinase-2 (MMP-2)and its relationship with angiogenesis in lung cancer.Expressions of MMP-2 and microvessel density (MVD) were detected with immunohistochemical staining in 42 cases of lung cancer.The expression rate of MMP-2 protein was 62%.The expression of MMP-2 protein was closely positive correlation with metastasis and with survival(P0.05). In 42 cases of lung cancer,MVD was 18.33~67.67(43.56±10.29).MVD in MMP-2 positively stained group (47.06±10.30) was significantly higher than that in negatively stained group(37.88±7.53)(P=0.004).[Conclusions]The expression of MMP-2 protein is closely correlated with the prognosis and angiogenesis in lung cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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