Title: Antitumor effects of the polysaccharides from Gloiopeltis furcata on H_(22) tumor bearing mice
Abstract: Objective To study the antitumor effect and the mechanism of the polysaccharide from Gloipeltis furcata on H_(22),tumor bearing mice.Methods The polysaccharides from Gloipeltis furcata were administered by oral route in mice bearing H_(22) tumor.The treatments lasted for 7 days.The inhibition rate against H_(22) tumor and the indices of thymus, spleen and liver were measured.In addition,the levels of antibodies against H_(22) tumor and GPT in serum,and GPT,GOT,MDA and SOD in liver were measured using commercially available kits.Results The administration of the polysaccharides from Gloipeltis furcata(200 mg·kg~(-1)·d~(-1) and 400 mg·kg~(-1)·d~(-1) ) for 7 days,the inhibition rates of H_(22) tumor were 35.64%(P0.01) and 36.63%(P0.01),respectively.Its mechanism of antitumor effects maybe enhance the specific immunity and raised the level of antibodies against tumor,and the ability of the free radical scavenging.At the same time,the liver could be protected by the polysaccharide of Gloipeltis furcata in mice bearing H_(22).tumor.Conclusion The present investigation showed that the polysaccharides from Gloipeltis furcata possess antitumor effect.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 1
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