Title: Therapeutic efficacy of metformin combined with atorvastatin in the treatment of diabetic mellitus complicated by hyperlipidemia
Abstract: Objective To investigate the therapeutic efficacy and safety of metformin combined with atorvastatin in the treatment of diabetic mellitus complicated by hyperlipidemia.Methods 142 cases of diabetic mellitus with hyperlipidemia were assigned to observation group(n=72) and control group(n=72) randomly,and the observation group received metformin combined with atorvastatin,while the control group was given metformin.All patients received 12-week course of treatment,and then the therapeutic efficacy and incidence of adverse reactions between the 2 groups were compared.Results Before treatment,there were no significant differences in the fasting glucose(FPG),2h postprandial blood glucose(2h-PG),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) between the 2 groups(P0.05).After treatment,the FPG,2h-PG,TG,TC and LDL-C in the observation group were significantly lower than those in the control group,respectively(P0.05),but the HDL-C was significantly higher than that in the control group(P0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P0.05).Conclusion The metformin combined with atorvastatin is able to correct disorders of glucose and lipid metabolism in diabetic mellitus with hyperlipidemia.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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