Title: Treatment of medium degree acne vulgaris with isotretinoin
Abstract: Objective: To evaluate the clinical efficacy and safety of isotretinoin in the treatment of medium degree acne vulgaris. Methods: A randomized parallel controlled clinical study was performed in 122 patients with medium degree acne vulgaris. The test group was treated with isotretinoin (10 mg bid, for 6 weeks) and the others, as control, were treated with viaminate (50 mg bid, for 6 weeks). The change-in-acne scores (including comedo, papules, pustules, cyst and sebum excretion) were counted in the end of every two weeks. Results: The change-in-acne scores in the isotretinoin group increased from (0.216 6± 0.129 1) to (6.246 9 ± 1.182 6) and that in the viaminate group increased from (0.129 0 ± 0.319 1) to (5.629 7 ± 1.448 9). There was significant difference in the reduction of the change-in-acne scores between the two groups. After 6-week-treatment the cure rate and the response rate were 58.18% and 100.00% respectively in the isotretinoin group. Otherwise, in the control group, they are 22.41% and 82.75% respectively, which was statistically less than those in the isotretinoin group. There were 23 patients with the local adverse reactions in the isotretinoin group and 31 patients with such reactions in the control group. There was no statistical difference in the adverse reactions between the two groups (P = 0.207 6). Conclusion: Isotretinoin is more effective in the treatment of medium degree acne vulgaris.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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