Title: Associations between the C to T Mutation at Nucleotide 3256 of Mitochondrial tRNA~(Leu(UUR)) Gene and Type 2 Diabetes Mellitus
Abstract: Objective To assess the prevalence of the C to T mutation at nucleotide 3256(mt3256) of the mitochondrial transfer RNALeu(tRNALeu) gene in type 2 diabetes mellitus(T2DM) in Henan Han population and their relationship.Methods Total 138 cases randomly selected,unrelated T2DM cases and 104 matched healthy controls were screened for the mutation by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique and PCR-direct-sequencing.Results The mt3256 mutation were not identified in the type 2 diabetic patients and the controls.Conclusion The tRNALeu(UUR)mt3256C→T mutation seems not be related to diabetes mellitus.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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