Title: The clinical distribution, laboratory diagnosis and drug resistance in 758 cases of conditional pathogenic fungal infections
Abstract: Objective To study the clinical distribution, laboratory diagnosis and drug resistance situation of conditional pathogenic fungal infections of our hospital, so as to provide basis for the guidance of clinical diagnosis and rational use of drugs. Methods We analyzed the classification, drug sensitivity and 1, 3-beta-D-glucan assay(G test) situation of 758 cases of conditional pathogenic fungal which came from each ward specimens in our hospital from January 2013 to January 2014. Results The conditional pathogenic fungal was isolated mainly from the patient, including sputum, blood, body fluid and pus etc. The strains of Candida albicans, Candida parapsilosis, Candida glabrata, Candida tropicalis, Cryptococcus neoformans and others were 562(74.14%), 88(11.61%), 49(6.46%), 38(5.01%), 13(1.72%) and 8(1.06%), respectively. The drug resistance rates of Candida albicans, Candida parapsilosis, folds of Candida and Cryptococcus neoformans to flucytosine, amphotericin B, fluconazole and voriconazole were low(10%), but higher resistance rate for itraconazole(10%). The drug resistance rates of Candida glabrata, Candida tropicalis and Candida krusei to Fluconazole and itraconazole, voriconazole were high(10%). Fungal culture and G test were done at the same time in 164 cases which were highly suspected as systemic fungal infection or fungal septicemia, with positive rates being 60.37%and 76.83%, respectively. Conclusion The Candida infection was mainly in respiratory tract, digestive tract and urinary tract. The drug sensitivities of Candida albicans in different regions, different types were different. Hence, the rapid and accurate identification and drug sensitivity test play an important role in clinical diagnosis and treatments.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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