Title: The Experiment Study of Kaiyuqingre's Prescription on the Expression of Sterol Regulatory Element Binding Protein-1c and Fatty Acid Synthase in Peritoneal Adipose Tissue of Spontaneous Type 2 Diabetes Mellitus Rats(OLETF rats)
Abstract: Objective:To observe the effect of Kaiyuqingre's Prescription on the protein and mRNA expression of sterol regulatory element binding protein-1c and fatty acid synthase in peritoneal adipose tissue of spontaneous Type 2 Diabetes Mellitus rats(OLETF rats).Methods:A control study was carried out between the OLETF rats and LETO rats,and all OLETF rats were divided into three groups randomly:Model group,Metformin group and Kaiyuqingre's Prescription group.Immunohistochemical method and real-time flourescent quantitative polymerase chain reaction(PCR)technology were used to detect the expression of sterol regulatory element binding protein-1c and fatty acid synthase in adipose tissue from the protein and gene levels in each group.Results: The sterol regulatory element binding protein-1c and fatty acid synthase protein and mRNA expression in rats' adipose tissue:Contrast to Modal group,the Kaiyuqingre's Prescription group is significantly lower.Conclusion:Kaiyuqingre's Prescription has a role of reducing the expression of protein and mRNA of sterol regulatory element binding protein-1c and fatty acid synthase in adipose tissue of spontaneous Type 2 Diabetes Mellitus rats.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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