Title: Preemptive analgesia by intravenous ketamine and tramadol in thoracotomy
Abstract: Objective To compare the preemptive analgesia of intravenous ketamine and tramadol pre-and intraoperatively in thoracotomy.Methods Ninety patients,ASAⅠ~Ⅱ,were scheduled for thoracotomy under general anesthesia supplemented by thoracic epidural analgesia.Patients were randomly divided into 3 groups.In Group K intravenous ketamine was administered as a bolus dose of 1.5mg/kg 10min prior to skin incision and then maintained continuously until skin closure at a dosage of 0.5mg·kg -1·h -1.In Group T intravenous tramadol was administered in the same way as Group K.Group P received saline as a placebo.The patient-controlled epidural analgesia (PCEA) devices were used in all patients after operation.We observed VAS score and Prince-Henry scale (PHS),the time of first PCEA activation,the valid number of press PCEA and the total consumption of analgesic after operation.Results The postoperative VAS and PHS were markedly lower in Group T compared with the other two groups(P0.05),but there were no difference between Group K and P,except that the lower PHS scores at 0h,30min and 1h in Group K than in Group P.The time of first PCEA activation was significantly longer in Group T than that in Group K and P(P0.05),without the difference between Group K and P.The total number of press PCEA was obviously smaller in Group T than that in Group P(P0.05).Markedly smaller consumption of analgesic after operation was found in Group T than that in Group P(P0.05).Conclusion Intravenous tramadol may provide reliable preemptive analgesia following thoracotomy while ketamine could not have the effect of preemptive analgesia.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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