Title: Expressions and clinical significance of CXCR4 and CCR7 in nasopharyngeal carcinoma
Abstract: Objective To explore the expression of CXC chemokine receptor-4(CXCR4) and CC chemokine receptor-7(CCR7) in nasopharyngeal carcinoma(NPC) and its clinical significance. Methods Sixty patients with NPC admitted in our hospital from January 2012 to October 2013 were randomly selected for NPC tissue,which was assigned as the disease group. Another 30 cases with nasopharyngeal inflammation were selected as control group for normal nasopharyngeal tissue. CXCR4 and CCR7 in two groups were detected with expression by immunohistochemistry. Results The positive expression cases of CCR7 and CXCR4 in the disease group were 32cases and 27 cases respectively, which were higher than those in the control group with 6 cases and 4 cases, and there were statistically significant different(P0.05). The positive expression of CCR7 and CXCR4 in Ⅲ stage andⅣ stage were 22 cases and 16 cases, which were higher than those in Ⅰ stage and Ⅱ stage with 10 cases and 11 cases, and the difference has statistical significance(P0.05). The positive expression of CCR7 in M1stage was 24,which was higher than that in M0stage with 8 cases, and the difference was statistically significant(P0.05). The positive expression of CCR7 and CXCR4 in patients with lymph node metastasis were 23 cases and 24 cases, which were higher than in patients without metastasis with 9 and 3 cases, and the difference was statistically significant(P0.05). Conclusion The positive expressions of CCR7 and CXCR4 in patients with NPC were significantly higher than those in non-carcinoma tissue. It is related with clinical stage and lymph node metastasis. CXCR4 and CCR7play important roles in the occurrence and development of nasopharyngeal carcinoma.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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Cited By Count: 1
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