Title: Synthesis of N-(5-amino-2,4-diethoxyphenyl)benzamide
Abstract:Through acylation and reduction reaction,N-(5-amino-2,4-diethoxyphenyl) benzamide(DEBAB)was synthesized from 2,4-diethoxy-5-nitroaniline(DEANB)and the experimental conditions,such as materials ratio,r...Through acylation and reduction reaction,N-(5-amino-2,4-diethoxyphenyl) benzamide(DEBAB)was synthesized from 2,4-diethoxy-5-nitroaniline(DEANB)and the experimental conditions,such as materials ratio,reaction temperature and reaction time,were investigated.Proper experimental conditions for acylation reaction were found as:n(DEANB)∶n(benzoyl chloride)= 1∶1.25,H2O and CH3OH as solvent,K2CO3 as deacid reagent reaction temperature 0 ℃,reaction time 1 h,the yield of N-(2,4-diethoxy-5-nitrophenyl) benzamide(DEBNB)was 90.95% based on DEANB and the purity was 98.35% as determined by HPLC;proper reduction reaction conditions were found as:n(DEBNB)∶n(Fe)= 1∶4,H2O and C2H5OH as solvent,reaction temperature 80 ℃,reaction time 5 h,pressure of hydrogen 1.5 MPa,the yield of DEDAB was 89.93% based on DEDNB and the purity was 98.96% as determined by HPLC.The molecular structures of product and its intermediates were identified by 1H-NMR,MS and FT-IR.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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