Title: Effect of U69 593 on L-type calcium current in isolated rabbit ventricular myocytes
Abstract:AIM: To investigate the effect of U69 593 on the L type calcium current (I Ca·L ) in isolated rabbit ventricular myocytes. METHODS: I Ca·L was recorded by using the whole cell voltage clamp technique....AIM: To investigate the effect of U69 593 on the L type calcium current (I Ca·L ) in isolated rabbit ventricular myocytes. METHODS: I Ca·L was recorded by using the whole cell voltage clamp technique. RESULTS: U69 593 at 100 nmol/L significantly increased I Ca·L at the test potential from -20 mV to +40 mV. The peak of I Ca·L was increased from -7.1±0.4 pA/pF to -8.3±0.5 pA/pF with maximal activation potential at +10 mV (by 18.3%±3.5%, P 0.01 vs control, n =8). The steady state activation and inactivation of I Ca·L was not affected by 100 nmol/L U69 593. CONCLUSION: The present study demonstrated that U69 593 increased I Ca·L in isolated rabbit ventricular myocytes.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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