Title: CoCl_(2) Precteating inhibits the apoptosis of hippocampal neurons induced by hypoxia-reoxygenation
Abstract: Objective To study the effect of CoCl-2 pretreating on apoptosis of hippocampal neurons induced by hypoxia-reoxygenation. Methods Primary cultured newborn rat hippocampal neurons were treated with CoCl-2.Then,the neurons were exposed to anoxic environment.TUNEL staining method and confocal laser microscope were used to examine separately the apoptotic neurons,intracellular Ca 2+ concentration and mitochodrial membrane potential after anoxic exposure. Results CoCl-2 pretreating greatly decreased the apoptotic neurons induced by acute hypoxia-reoxygenation,and also stabilized the intracellular Ca 2+ concentration and the mitochondrial membrane potential during hypoxic exposure.Conclusion CoCl-2 pretreating protects the apoptosis of hippocampal neurons induced by hypoxia-reoxygenation.The protective effect may relate stabilize the intracellular Ca 2+ concentration and the mitochondrial membrane potential during hypoxia.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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