Title: Effect of Dahuang Zhechong Pill on Kidney Interstitial Fibrosis and TGF-β_1 Expression of Rats
Abstract: Objective:To explore the effect of Dahuang Zhechong Pill (DZP) on kidney interstitial fibrosis and TGF-β_1 expression of rats. Methods:Rats were randomly divided into model group,TCM group (treated by DZP),WM group (treated by losartan) after suc- cessful modeling by adenine.A normal group was set up as the control.Serum creatine (SCr) and urea nitrogen (BUN) were deter- mined at the 3rd and 6th week.The degree of kidney interstitial fibrosis was examined by periodic aice-Sehiff's (PAS) stain and Masson stain.TGF-β_1 protein and TGF-β_1 mRNA expression were observed by immunohistochemistry and in situ hybridization.Results:Compared with the model group,the kidney function was improved,the degree of interstitial fibrosis got obvi- ous lessened,and TGF-β_1 expression was down-regulated in TCM and WM group respectively.The effect of TCM group was superior to that of WM group.Conclusion:DZP could improve the degree of interstitial fibrosis by down-regulating TGF-β_1 expression.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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