Title: Effect of sibutramine on obese mice induced by gold thioglucose(GTG)
Abstract: AIM To assess the effect of sibutramine on obese mice. METHODS Male mice were induced obesity by IP gold thioglucose(GTG) 800 mg·kg -1 once,while the control mice were given the same valume saline.On the 21th day,the obese animals were devided into five groups and administraed orally sibutramine 3,6,12 mg·kg -1 or amfepramoni hydrochloridi 90 mg·kg -1 or 0 5% CMC for 18 days respectively. RESULTS In sibutramine treated GTG mice,the weight gain,weight of fat pads,Lee's indexes,size of adipocytes, the levels of serum TG and insulin were all reduced. CONCLUSION Sibutramine has an anti obesity action in GTG mice.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot