Title: Study on the characteristics of metabolic syndrome model in mice and therapeutic effect of sibutramine
Abstract: Aim To study the characteristics of mouse metabolic syndrome(MS) model induced by high-fat diet and the effect of sibutramine on MS mice.Methods 9-week-old male C57BL/6J mice,fed with high-fat diet(10% lard,2% cholesterol,and 0.4% sodium cholate in basic diet) for 18.5 weeks were treated with saline or sibutramine 8 mg·kg-1 for 10 days.The body weight,wet weight of visceral fat and liver,liver free fatty acid(FFA) content,serum level of lipid,glucose and insulin were examined at the end of the treatment.Results The excessive fat in abdominal cavity was accumulated in MS mice accompanied with hypercholesterolemia,hyperglycemia,hyperinsulinemia,and insulin resistance.In addition,liver weight and grade of hepatic steatosis increased significantly in MS mice.These symptoms in MS mice were similar to those in human beings.After 10 days treatment,sibutramine reduced the obesity related indices,ameliorated glucose and lipid metabolism abnormality,and enhanced insulin sensitivity,but it increased liver FFA content and had no obvious effect on liver weight and hepatic steatosis in MS mice.Conclusions MS model can be induced in C57BL/6J mice by long-term feeding with high-fat diet and sibutramine has a certain therapeutic effect on MS in mice.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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