Title: Expression of cyclin E and related cytokines and its correlation with neoplasia,invasion and metastasis of renal cell carcinoma
Abstract: Objective To investigate the effects of the gene expression of cyclinE,CDK2 and P27 in renal carcinogenesis,and to explore its correlation with biological behaviors of tumor.Methods Immunohistochemical method and semiquantitative RT-PCR were applied to examine the expression of cyclin E,CDK2 and P27 proteins and mRNAs in 37 cases of renal cell carcinoma,13 cases of normal renal tissues adjacent to the tumor tissues.The relationship between those indexes and clinicopathological parameters were analyzed statistically.Results The positive rate of cyclin E and CDK2 in renal cell carcinomas was 51.4% and 43.2% respectively,significantly higher than in paracarcinoma normal renal tissues(P0.05).The expression of cyclinE and DCK2 was positively related with grade,stage and metastasis of tumors(P0.05).On the contrary,the positive rate of P27 expression in renal cell carcinoma tissues and paracarcinoma normal renal tissues was 48.6% and 69.2% respectively with the difference being significant(P0.05).Conclusion Abnormalities of cyclin E and CDK2 and P27 may play important roles in tumorigenesis and progression of renal cell carcinoma,and they are valuable predictors to evaluate the biological behaviors of the disease.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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