Title: Effect of Epimedium Flavanoids on Neuro-inflammatory Reaction in Alzheimer Disease Model Mice Induced by Lateral Ventricle Injection of β-amyloid
Abstract: Objective To investigate the effect of Epimedium flavanoids(EF)on neuro-inflammatory reaction in Alzheimer disease(AD)mice model.Methodsβ-amyloid 1-40(Aβ1-40)was injected to the right lateral ventricle of 2-month-old male ICR mice to induce AD model.Morris water maze and step-through tests were used to measure the learning and memory ability of mice.The concentrations of interleukin-1β(IL-1β)and tumor necrosis factor α(TNF-α)in the hippocampus were determined by radioimmunoassay.The expression of glial fibrillary acidic protein(GFAP)positive cells(astrocytes)was detected by immunochemistry staining.ResultsCompared with the sham-operation group,the learning and memory ability decreased(P0.05,P0.01),the concentrations of IL-1β and TNF-α in the hippocampus increased(P0.01)and the expression of astrocytes in the hippocampus elevated(P0.05)in Aβ1-40 injection model mice.Intragastric administration of EF(100 and 300 mg/kg)for 3 weeks significantly improved the learning and memory ability(P0.05,P0.01),decreased IL-1β and TNF-α concentrations in the hippocampus(P0.05,P0.01)and inhibited the expression of astrocytes in the hippocampus(P0.05),compared with Aβ1-40 injection model mice.ConclusionEF can decrease the inflammatory reaction in the brain of mice induced by Aβ.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 1
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