Title: Expression and Significance of COX-2 and Ki-67 Protein in Condyloma Acuminata
Abstract: Objective To detect COX-2 and Ki-67 protein in keratinocytes of Condyloma acuminatum(CA),and to explore their roles in pathogenesis.Methods The expression of COX-2 and Ki-67 protein in 38 cases of CA and 15 normal controls was detected respectively with immunohistochemistry staining(SP).Results The positive rate of COX-2 protein was 68.4%(26/38),0.00%(0/15)in CA and normal skin tissue respectively.The expression of intensity was 3.921±0.254,0.883±0.088 respectively.There was significant difference in the expression of COX-2 protein between in the CA and normal skin tissues(P0.01);The positive rate of Ki-67 protein was 84.2%(32/38),60.0%(9/15) in CA and normal skin tissue respectively,the expression of intensity was 0.234±0.021,0.05±0.006 respectively.There was no significant difference in the positive rate of Ki-67 protein between in the CA and normal skin tissues(P0.05).But there was significant difference in the expression of intensity of Ki-67 protein between in the CA and normal skin tissues(P0.01);There was a statistically positive correlation between COX-2 and Ki-67 protein overexpression in CA(r= 0.497,P0.01).Conclusion There is a statistically positive correlation between COX-2 and Ki-67 protein overexpression in CA;the overexpression of COX-2 protein in CA may play some roles in process of tumour cell proliferation.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot