Title: Insulin Pump Continuous Infusion of Novorapid in Intensive Treatment of T2DM Complicated by Secondary Sulfonylureas Failure
Abstract: Objective To explore the effect of insulin pomp continuous subcutaneous insulin infusion (CSⅡ) on T2DM complicated by secondary sulfonylureas failure.Methods One hundred T2DM patients complicated by secondary sulfonylureas failure were divided randomly into groups CSⅡ (receiving CSⅡ)and MSⅡ (receiving conventional insulin subcutaneous injection,twice/d),50 in each.Both were given diabetes education,diet control and regular exercises.MSⅡ group were injected with 30 R novolin 30 min before breakfast,supper every day,4 weeks,and CSⅡ group given CSⅡ treatment (novorapid).The blood sugar (before meals,2 h after meals,before retiring,2:00 am blood sugar),insulin dosage,duration of normal glucose,length of hospital stay and incidence of low blood sugar were compared between 2 groups before treatment and after.Results After treatment,2 h postprandial glucose,insulin dosage,duration of normal glucose,length of hospital stay were 7.8±1.2mmol/L,0.58±0.14 U·kg-1·d-1,3.2±1.9 d,10.4±2.6 d,respectively,in CSⅡ group,and 9.0±1.4 mmol/L,0.74±0.17 U·kg-1·d-1,7.7±2.9 d,12.9±3.5 d,respectively,in MSⅡ group,the difference was significant (P0.05).There was no hypoglycemia occurring in CSⅡ group,but there were 4 in MSⅡ group.Conclusion The effect of insulin pump CSⅡ is remarkably superior to that of MSⅡ in intensive treatment of T2DM complicated by secondary sulfonylureas failure.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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