Title: Microwave-assisted Synthesis of 2′-Oxo-cyclopentanecarboxylic Acid Ethyl Ester
Abstract: Orthogonal test was performed to examine the influences of reaction conditions on microwave-assisted synthesis of 2′-oxo-cyclopentanecarboxylic acid ethyl ester from diethyl adipate.The results showed that the influence order of three factors is: reaction temperature reaction time catalyst dosage.The optimal conditions were found as follows: reaction temperature 90 ℃,reaction time 50 min,the molar ratio of catalyst to diethyl adipate 1.1∶1,providing 99.5% yield.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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