Title: [Combination of etoposide with cisplatin or cyclophosphamide in the treatment of mouse Lewis lung carcinoma].
Abstract:The effect of sequential combination of etoposide with cisplatin or cyclophosphamide on mouse Lewis lung carcinoma was investigated. Tumor cells were inoculated i.v. on day 0. Drugs were administered ...The effect of sequential combination of etoposide with cisplatin or cyclophosphamide on mouse Lewis lung carcinoma was investigated. Tumor cells were inoculated i.v. on day 0. Drugs were administered i.p. In combined treatment etoposide was consecutively administered once daily for 5 days on days 1 to 5 and 2 to 6 when cisplatin or cyclophosphamide were administered singly on days 6 and 1, respectively. In the combination of etoposide with cisplatin a highly synergistic effect was observed irrespective of the day of cisplatin administration. In the other combination with cyclophosphamide, a synergistic effect was similarly observed but the degree was much higher when cyclophosphamide was administered prior to etoposide administration.Read More
Publication Year: 1986
Publication Date: 1986-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 2
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