Title: Expression of Insulin-like Growth Factor and Insulin-like Growth Factor Receptor in Gastrointestinal Stromal Tumorsand Their Significance
Abstract: [Objective] To investigate the expression of insulin-like growth factor 1(IGF1), IGF2, insulin-like growth factor 1 receptor (IGF1R), IGF2R and their clinicopathologic significance in gastrointestinal stromal tumors (GISTs), and the correlation between IGFs and IGFRs. [Methods] Immunohistochemical method SABC was used to detect the expression of IGF1, IGF2, IGF1R, and IGF2R in 55 cases of GISTs. The relationship between the positive rate and clinicopathologic data (including sex, histological subtype, tumor size, histological grade and localization) was analyzed. [Results] Of 55 cases of GISTs, 34 cases were found positive for IGF1 (61.8%), 27 cases for IGF2 (49.1%), 6 cases for IGF1R (10.9%), and 10 cases for IGF2R (18.2%). Significant difference in the positive rate of IGF1 or IGF2 was found among different tumor size or histological grade groups (P 0.05). No significant difference was found among different groups of sex, histological subtype, and localization (P 0.05). Close correlation was found between IGF1 and IGF2, IGF1R and IGF1, IGF1R and IGF2, IGF1R and IGF2R, IGF2R and IGF2 (P 0.05), respectively. [Conclusion] IGF1 and IGF2 play some roles in pathogenesis and proliferation in GISTs, which may be used as an objective index for distinguishing malignant from benign GISTs. IGF1R and IGF2R may play some roles by regulating expression of IGF1 and IGF2 in GISTs, but not the only decisive factor.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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