Challenging Treatment-Resistant Major Depressive Disorder: A Roadmap for Improved Therapeutics

Name: Work Video:
Duration: 3 min 30 s
Rafael T. de Sousa; Marcus V. Zanetti; André R. Brunoni; Rodrigo Machado‐Vieira
{'id': 'https://openalex.org/W2342584978', 'doi': 'https://doi.org/10.2174/1570159x13666150630173522', 'title': 'Challenging Treatment-Resistant Major Depressive Disorder: A Roadmap for Improved Therapeutics', 'display_name': 'Challenging Treatment-Resistant Major Depressive Disorder: A Roadmap for Improved Therapeutics', 'publication_year': 2015, 'publication_date': '2015-07-25', 'ids': {'openalex': 'https://openalex.org/W2342584978', 'doi': 'https://doi.org/10.2174/1570159x13666150630173522', 'mag': '2342584978', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26467411', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4761633'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1570159x13666150630173522', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S85221069', 'display_name': 'Current Neuropharmacology', 'issn_l': '1570-159X', 'issn': ['1570-159X', '1875-6190'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4761633?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064190623', 'display_name': 'Rafael T. de Sousa', 'orcid': 'https://orcid.org/0000-0001-9284-2325'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Rafael T. de Sousa', 'raw_affiliation_strings': ['Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil;', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084496632', 'display_name': 'Marcus V. Zanetti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Marcus V. Zanetti', 'raw_affiliation_strings': ['Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Brazil;', 'Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil;', 'Laboratory of Psychiatric Neuroimaging, LIM-21, Department and Institute of Psychiatry, University of Sao Paulo, Brazil;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Psychiatric Neuroimaging, LIM-21, Department and Institute of Psychiatry, University of Sao Paulo, Brazil;', 'institution_ids': ['https://openalex.org/I17974374']}, {'raw_affiliation_string': 'Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil;', 'institution_ids': ['https://openalex.org/I17974374']}, {'raw_affiliation_string': 'Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Brazil;', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063506824', 'display_name': 'André R. Brunoni', 'orcid': 'https://orcid.org/0000-0002-6310-3571'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Andre R. Brunoni', 'raw_affiliation_strings': ['Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil;', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009988293', 'display_name': 'Rodrigo Machado‐Vieira', 'orcid': 'https://orcid.org/0000-0002-4830-1190'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': True, 'raw_author_name': 'Rodrigo Machado-Vieira', 'raw_affiliation_strings': ['Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, University of Sao Paulo, Brazil, Address: Instituto de Psiquiatria do HC-FMUSP, 3o andar, LIM-27, Rua Dr. Ovidio Pires de Campos, 785, Postal code 05403- 010, Sao Paulo, SP, Brazil.,Brazil'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, University of Sao Paulo, Brazil, Address: Instituto de Psiquiatria do HC-FMUSP, 3o andar, LIM-27, Rua Dr. Ovidio Pires de Campos, 785, Postal code 05403- 010, Sao Paulo, SP, Brazil.,Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5009988293'], 'corresponding_institution_ids': ['https://openalex.org/I17974374'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.557, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.383914, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '13', 'issue': '5', 'first_page': '616', 'last_page': '635'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11071', 'display_name': 'Treatment of Major Depression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11071', 'display_name': 'Treatment of Major Depression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10854', 'display_name': 'Bipolar Disorder and Treatment', 'score': 0.986, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/treatment-resistant-depression', 'display_name': 'Treatment-Resistant Depression', 'score': 0.7612816}, {'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.60337555}, {'id': 'https://openalex.org/keywords/adjunctive-treatment', 'display_name': 'Adjunctive treatment', 'score': 0.46047583}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.41424522}], 'concepts': [{'id': 'https://openalex.org/C2780051608', 'wikidata': 'https://www.wikidata.org/wiki/Q42844', 'display_name': 'Major depressive disorder', 'level': 3, 'score': 0.8798772}, {'id': 'https://openalex.org/C2779177272', 'wikidata': 'https://www.wikidata.org/wiki/Q76560', 'display_name': 'Antidepressant', 'level': 3, 'score': 0.8097311}, {'id': 'https://openalex.org/C2777342061', 'wikidata': 'https://www.wikidata.org/wiki/Q7836891', 'display_name': 'Treatment-resistant depression', 'level': 4, 'score': 0.7612816}, {'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.60337555}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5606154}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.47192144}, {'id': 'https://openalex.org/C3018162438', 'wikidata': 'https://www.wikidata.org/wiki/Q1304270', 'display_name': 'Adjunctive treatment', 'level': 2, 'score': 0.46047583}, {'id': 'https://openalex.org/C3019858935', 'wikidata': 'https://www.wikidata.org/wiki/Q4340209', 'display_name': 'Depressive symptoms', 'level': 3, 'score': 0.45169848}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.4227413}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.41424522}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19038907}, {'id': 'https://openalex.org/C2780733359', 'wikidata': 'https://www.wikidata.org/wiki/Q331769', 'display_name': 'Mood', 'level': 2, 'score': 0.11547387}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.071305186}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.065283954}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D061218', 'descriptor_name': 'Depressive Disorder, Treatment-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016206', 'descriptor_name': 'Databases, Bibliographic', 'qualifier_ui': 'Q000706', 'qualifier_name': 'statistics & numerical data', 'is_major_topic': False}, {'descriptor_ui': 'D016206', 'descriptor_name': 'Databases, Bibliographic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061218', 'descriptor_name': 'Depressive Disorder, Treatment-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1570159x13666150630173522', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S85221069', 'display_name': 'Current Neuropharmacology', 'issn_l': '1570-159X', 'issn': ['1570-159X', '1875-6190'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4761633', 'pdf_url': 'https://europepmc.org/articles/pmc4761633?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761633', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26467411', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4761633', 'pdf_url': 'https://europepmc.org/articles/pmc4761633?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.69, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 178, 'referenced_works': ['https://openalex.org/W127595161', 'https://openalex.org/W1489185814', 'https://openalex.org/W177374693', 'https://openalex.org/W1969010498', 'https://openalex.org/W1970665765', 'https://openalex.org/W1973061797', 'https://openalex.org/W1973534109', 'https://openalex.org/W1974109816', 'https://openalex.org/W1974112189', 'https://openalex.org/W1976396510', 'https://openalex.org/W1977073959', 'https://openalex.org/W1977126872', 'https://openalex.org/W1979281142', 'https://openalex.org/W1980475719', 'https://openalex.org/W1983900457', 'https://openalex.org/W1984052858', 'https://openalex.org/W1986641829', 'https://openalex.org/W1987459299', 'https://openalex.org/W1988259630', 'https://openalex.org/W1990184143', 'https://openalex.org/W1992871284', 'https://openalex.org/W1996454121', 'https://openalex.org/W1996780673', 'https://openalex.org/W1998678846', 'https://openalex.org/W1998767099', 'https://openalex.org/W1998960607', 'https://openalex.org/W1999412968', 'https://openalex.org/W2000209756', 'https://openalex.org/W2000534870', 'https://openalex.org/W2002131408', 'https://openalex.org/W2002540421', 'https://openalex.org/W2003640217', 'https://openalex.org/W2003944462', 'https://openalex.org/W2003982930', 'https://openalex.org/W2007880575', 'https://openalex.org/W2010175737', 'https://openalex.org/W2011003051', 'https://openalex.org/W2011054360', 'https://openalex.org/W2011750425', 'https://openalex.org/W2011935138', 'https://openalex.org/W2012655610', 'https://openalex.org/W2014577629', 'https://openalex.org/W2015426483', 'https://openalex.org/W2017172461', 'https://openalex.org/W2017639205', 'https://openalex.org/W2017663874', 'https://openalex.org/W2017680611', 'https://openalex.org/W2020739757', 'https://openalex.org/W2020924268', 'https://openalex.org/W2021939430', 'https://openalex.org/W2023456394', 'https://openalex.org/W2024457073', 'https://openalex.org/W2024803642', 'https://openalex.org/W2025170039', 'https://openalex.org/W2026949325', 'https://openalex.org/W2029446070', 'https://openalex.org/W2031799297', 'https://openalex.org/W2032739515', 'https://openalex.org/W2033132892', 'https://openalex.org/W2034750014', 'https://openalex.org/W2035353883', 'https://openalex.org/W2036735145', 'https://openalex.org/W2037036089', 'https://openalex.org/W2037486662', 'https://openalex.org/W2039961483', 'https://openalex.org/W2040154223', 'https://openalex.org/W2041565742', 'https://openalex.org/W2042982960', 'https://openalex.org/W2047917340', 'https://openalex.org/W2050386004', 'https://openalex.org/W2051925083', 'https://openalex.org/W2051933342', 'https://openalex.org/W2052168906', 'https://openalex.org/W2053098983', 'https://openalex.org/W2055443965', 'https://openalex.org/W2055629924', 'https://openalex.org/W2061430729', 'https://openalex.org/W2062103870', 'https://openalex.org/W2062644160', 'https://openalex.org/W2063773170', 'https://openalex.org/W2064453184', 'https://openalex.org/W2067753440', 'https://openalex.org/W2068508452', 'https://openalex.org/W2068597369', 'https://openalex.org/W2068927187', 'https://openalex.org/W2069520581', 'https://openalex.org/W2069965305', 'https://openalex.org/W2070007822', 'https://openalex.org/W2073079805', 'https://openalex.org/W2073281243', 'https://openalex.org/W2073395907', 'https://openalex.org/W2073585506', 'https://openalex.org/W2074535951', 'https://openalex.org/W2075486574', 'https://openalex.org/W2078835788', 'https://openalex.org/W2079581133', 'https://openalex.org/W2081618408', 'https://openalex.org/W2081624976', 'https://openalex.org/W2086712277', 'https://openalex.org/W2091259554', 'https://openalex.org/W2091363925', 'https://openalex.org/W2094669374', 'https://openalex.org/W2099564543', 'https://openalex.org/W2099835839', 'https://openalex.org/W2102656145', 'https://openalex.org/W2103255996', 'https://openalex.org/W2104518967', 'https://openalex.org/W2106674256', 'https://openalex.org/W2109163290', 'https://openalex.org/W2109334244', 'https://openalex.org/W2109355532', 'https://openalex.org/W2110962760', 'https://openalex.org/W2111373412', 'https://openalex.org/W2111963501', 'https://openalex.org/W2112249597', 'https://openalex.org/W2114693958', 'https://openalex.org/W2115471458', 'https://openalex.org/W2115504852', 'https://openalex.org/W2116159412', 'https://openalex.org/W2116302039', 'https://openalex.org/W2118826874', 'https://openalex.org/W2118954082', 'https://openalex.org/W2120839478', 'https://openalex.org/W2121789874', 'https://openalex.org/W2122681119', 'https://openalex.org/W2124175406', 'https://openalex.org/W2125094332', 'https://openalex.org/W2127211061', 'https://openalex.org/W2129573214', 'https://openalex.org/W2133433402', 'https://openalex.org/W2134691750', 'https://openalex.org/W2136722242', 'https://openalex.org/W2137222998', 'https://openalex.org/W2137435000', 'https://openalex.org/W2137672274', 'https://openalex.org/W2137992068', 'https://openalex.org/W2139170222', 'https://openalex.org/W2140787893', 'https://openalex.org/W2140815719', 'https://openalex.org/W2141120613', 'https://openalex.org/W2141224145', 'https://openalex.org/W2143247032', 'https://openalex.org/W2146645762', 'https://openalex.org/W2147720794', 'https://openalex.org/W2148939808', 'https://openalex.org/W2149402043', 'https://openalex.org/W2151590183', 'https://openalex.org/W2151766665', 'https://openalex.org/W2153302911', 'https://openalex.org/W2153674729', 'https://openalex.org/W2154724239', 'https://openalex.org/W2155254553', 'https://openalex.org/W2155275341', 'https://openalex.org/W2155891669', 'https://openalex.org/W2156092714', 'https://openalex.org/W2159202946', 'https://openalex.org/W2160011621', 'https://openalex.org/W2161407094', 'https://openalex.org/W2164759779', 'https://openalex.org/W2170273380', 'https://openalex.org/W2178118559', 'https://openalex.org/W2178666919', 'https://openalex.org/W2179253402', 'https://openalex.org/W2182104458', 'https://openalex.org/W2189057525', 'https://openalex.org/W2317127866', 'https://openalex.org/W2317942085', 'https://openalex.org/W2333926891', 'https://openalex.org/W2340538438', 'https://openalex.org/W2399110179', 'https://openalex.org/W2404189504', 'https://openalex.org/W2616500375', 'https://openalex.org/W36293371', 'https://openalex.org/W40250867', 'https://openalex.org/W4231622706', 'https://openalex.org/W4242566730', 'https://openalex.org/W4250647223', 'https://openalex.org/W4254610042'], 'related_works': ['https://openalex.org/W4387127397', 'https://openalex.org/W4321367679', 'https://openalex.org/W4248535037', 'https://openalex.org/W3107906657', 'https://openalex.org/W3031114750', 'https://openalex.org/W2945361245', 'https://openalex.org/W2557588769', 'https://openalex.org/W2549032866', 'https://openalex.org/W2522921805', 'https://openalex.org/W2061252706'], 'abstract_inverted_index': {'Major': [0], 'depressive': [1, 18, 84, 222], 'disorder': [2], '(MDD)': [3], 'is': [4, 20, 126], 'associated': [5], 'with': [6], 'a': [7, 51, 123], 'significant': [8], 'burden': [9], 'and': [10, 42, 88, 155, 165, 201, 210], 'costs': [11, 44], 'to': [12, 38, 73, 119, 136, 145, 207], 'the': [13, 26, 30, 39, 54, 79, 91, 108, 162, 186, 198], 'society.': [14], 'As': [15], 'remission': [16, 166], 'of': [17, 25, 45, 53, 107, 150, 180, 188, 197], 'symptoms': [19], 'achieved': [21], 'in': [22, 130, 142], 'only': [23], 'one-third': [24], 'MDD': [27, 133], 'patients': [28], 'after': [29, 134], 'first': [31], 'antidepressant': [32, 121, 139, 156], 'trial,': [33], 'unsuccessful': [34], 'treatments': [35, 182], 'contribute': [36], 'largely': [37], 'observed': [40], 'suffering': [41], 'social': [43], 'MDD.': [46], 'The': [47, 111, 177], 'present': [48], 'article': [49], 'provides': [50], 'summary': [52], 'therapeutic': [55], 'strategies': [56, 154], 'that': [57, 115], 'have': [58], 'been': [59], 'tested': [60], 'for': [61, 172, 183], 'treatment-resistant': [62], 'depression': [63], '(TRD).': [64], 'A': [65, 100], 'computerized': [66], 'search': [67], 'on': [68], 'MedLine/PubMed': [69], 'database': [70], 'from': [71, 122], '1975': [72], 'September': [74], '2014': [75], 'was': [76], 'performed,': [77], 'using': [78], 'keywords': [80], '“treatment-resistant': [81], 'depression”,': [82], '“major': [83], 'disorder”,': [85], '“adjunctive”,': [86], '“refractory”': [87], '“augmentation”.': [89], 'From': [90], '581': [92], 'articles': [93, 106], 'retrieved,': [94], 'two': [95, 146], 'authors': [96], 'selected': [97], '79': [98], 'papers.': [99], 'manual': [101], 'searching': [102], 'further': [103], 'considered': [104], 'relevant': [105], 'reference': [109], 'lists.': [110], 'evidence': [112], 'found': [113], 'supports': [114], 'adding': [116], 'or': [117, 147], 'switching': [118], 'another': [120], 'different': [124], 'class': [125], 'an': [127, 137], 'effective': [128], 'strategy': [129], 'more': [131, 148], 'severe': [132], 'failure': [135], 'initial': [138], 'trial.': [140], 'Also,': [141], 'subjects': [143], 'resistant': [144], 'classes': [149], 'antidepressants,': [151], 'some': [152], 'augmentation': [153], 'combinations': [157], 'should': [158], 'be': [159], 'considered,': [160], 'although': [161], 'overall': [163], 'response': [164], 'rates': [167], 'are': [168, 212], 'relatively': [169], 'low,': [170], 'except': [171], 'fast': [173], 'acting': [174], 'glutamatergic': [175], 'modulators.': [176], 'wide': [178], 'range': [179], 'available': [181], 'TRD': [184], 'reflects': [185], 'complexity': [187], 'MDD,': [189], 'which': [190], 'does': [191], 'not': [192], 'underlie': [193], 'diverse': [194], 'key': [195], 'features': [196], 'disorder.': [199, 223], 'Larger': [200], 'well-designed': [202], 'studies': [203], 'applying': [204], 'dimensional': [205], 'approaches': [206], 'measure': [208], 'efficacy': [209], 'effectiveness': [211], 'warranted.': [213], 'Keywords:': [214], 'Antidepressant,': [215], 'antipsychotic,': [216], 'diagnosis': [217], 'treatment,': [218], 'glutamate,': [219], 'monoamines,': [220], 'major': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2342584978', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-07T18:49:05.073092', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
