Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4387127397', 'doi': 'https://doi.org/10.1038/s41398-023-02602-3', 'title': 'Polygenic risk scores of lithium response and treatment resistance in major depressive disorder', 'display_name': 'Polygenic risk scores of lithium response and treatment resistance in major depressive disorder', 'publication_year': 2023, 'publication_date': '2023-09-28', 'ids': {'openalex': 'https://openalex.org/W4387127397', 'doi': 'https://doi.org/10.1038/s41398-023-02602-3', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37770441'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41398-023-02602-3', 'pdf_url': 'https://www.nature.com/articles/s41398-023-02602-3.pdf', 'source': {'id': 'https://openalex.org/S163345920', 'display_name': 'Translational Psychiatry', 'issn_l': '2158-3188', 'issn': ['2158-3188'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41398-023-02602-3.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013848104', 'display_name': 'Ying Xiong', 'orcid': 'https://orcid.org/0000-0002-6270-5220'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ying Xiong', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034173470', 'display_name': 'Robert Karlsson', 'orcid': 'https://orcid.org/0000-0002-8949-2587'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Robert Karlsson', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091150906', 'display_name': 'Jie Song', 'orcid': 'https://orcid.org/0000-0002-7357-2136'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Jie Song', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075545256', 'display_name': 'Kaarina Kowalec', 'orcid': 'https://orcid.org/0000-0003-3928-9879'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Kaarina Kowalec', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072483740', 'display_name': 'Christian Rück', 'orcid': 'https://orcid.org/0000-0002-8742-0168'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Christian Rück', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085174527', 'display_name': 'Robert Sigström', 'orcid': 'https://orcid.org/0000-0003-1505-1532'}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Robert Sigström', 'raw_affiliation_strings': ['Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025708588', 'display_name': 'Lina Jönsson', 'orcid': 'https://orcid.org/0000-0002-3175-103X'}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Lina Jonsson', 'raw_affiliation_strings': ['Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025627946', 'display_name': 'Caitlin C. Clements', 'orcid': 'https://orcid.org/0000-0003-2278-6465'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Caitlin C. Clements', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031412856', 'display_name': 'Erik Andersson', 'orcid': 'https://orcid.org/0000-0003-0088-8719'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Evelyn Andersson', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086589946', 'display_name': 'Julia Boberg', 'orcid': 'https://orcid.org/0000-0003-3399-2838'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Julia Boberg', 'raw_affiliation_strings': ['Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045289228', 'display_name': 'Cathryn M. Lewis', 'orcid': 'https://orcid.org/0000-0002-8249-8476'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Cathryn M. Lewis', 'raw_affiliation_strings': ["Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK"], 'affiliations': [{'raw_affiliation_string': "Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK", 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061802355', 'display_name': 'Patrick F. Sullivan', 'orcid': 'https://orcid.org/0000-0002-6619-873X'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Patrick F. Sullivan', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023024313', 'display_name': 'Mikael Landén', 'orcid': 'https://orcid.org/0000-0002-4496-6451'}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Mikael Landén', 'raw_affiliation_strings': ['Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012302685', 'display_name': 'Yi Lu', 'orcid': 'https://orcid.org/0000-0001-9933-3654'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Yi Lu', 'raw_affiliation_strings': ['Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'GBP', 'value_usd': 3422, 'provenance': 'doaj'}, 'apc_paid': {'value': 2790, 'currency': 'GBP', 'value_usd': 3422, 'provenance': 'doaj'}, 'fwci': 1.166, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.662284, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 84}, 'biblio': {'volume': '13', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10854', 'display_name': 'Bipolar Disorder and Treatment', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10854', 'display_name': 'Bipolar Disorder and Treatment', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11921', 'display_name': 'Electroconvulsive Therapy Studies', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11071', 'display_name': 'Treatment of Major Depression', 'score': 0.9836, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/treatment-resistant-depression', 'display_name': 'Treatment-Resistant Depression', 'score': 0.892452}, {'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.5659862}], 'concepts': [{'id': 'https://openalex.org/C2777342061', 'wikidata': 'https://www.wikidata.org/wiki/Q7836891', 'display_name': 'Treatment-resistant depression', 'level': 4, 'score': 0.892452}, {'id': 'https://openalex.org/C2780051608', 'wikidata': 'https://www.wikidata.org/wiki/Q42844', 'display_name': 'Major depressive disorder', 'level': 3, 'score': 0.85634065}, {'id': 'https://openalex.org/C2779177272', 'wikidata': 'https://www.wikidata.org/wiki/Q76560', 'display_name': 'Antidepressant', 'level': 3, 'score': 0.7596408}, {'id': 'https://openalex.org/C2777330709', 'wikidata': 'https://www.wikidata.org/wiki/Q131543', 'display_name': 'Electroconvulsive therapy', 'level': 3, 'score': 0.7032508}, {'id': 'https://openalex.org/C2778541603', 'wikidata': 'https://www.wikidata.org/wiki/Q152763', 'display_name': 'Lithium (medication)', 'level': 2, 'score': 0.6892584}, {'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.5659862}, {'id': 'https://openalex.org/C2776174506', 'wikidata': 'https://www.wikidata.org/wiki/Q131755', 'display_name': 'Bipolar disorder', 'level': 3, 'score': 0.51307976}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.5130738}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.47909454}, {'id': 'https://openalex.org/C70410870', 'wikidata': 'https://www.wikidata.org/wiki/Q199906', 'display_name': 'Clinical psychology', 'level': 1, 'score': 0.40611514}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40384674}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38850272}, {'id': 'https://openalex.org/C2776412080', 'wikidata': 'https://www.wikidata.org/wiki/Q7431605', 'display_name': 'Schizophrenia (object-oriented programming)', 'level': 2, 'score': 0.36510426}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3537484}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.10194284}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D061218', 'descriptor_name': 'Depressive Disorder, Treatment-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004565', 'descriptor_name': 'Electroconvulsive Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000928', 'descriptor_name': 'Antidepressive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D061218', 'descriptor_name': 'Depressive Disorder, Treatment-Resistant', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D061218', 'descriptor_name': 'Depressive Disorder, Treatment-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004565', 'descriptor_name': 'Electroconvulsive Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008094', 'descriptor_name': 'Lithium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008094', 'descriptor_name': 'Lithium', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41398-023-02602-3', 'pdf_url': 'https://www.nature.com/articles/s41398-023-02602-3.pdf', 'source': {'id': 'https://openalex.org/S163345920', 'display_name': 'Translational Psychiatry', 'issn_l': '2158-3188', 'issn': ['2158-3188'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539379', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980196', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37770441', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41398-023-02602-3', 'pdf_url': 'https://www.nature.com/articles/s41398-023-02602-3.pdf', 'source': {'id': 'https://openalex.org/S163345920', 'display_name': 'Translational Psychiatry', 'issn_l': '2158-3188', 'issn': ['2158-3188'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W116369744', 'https://openalex.org/W1493341253', 'https://openalex.org/W1531012550', 'https://openalex.org/W1537538750', 'https://openalex.org/W159401344', 'https://openalex.org/W1617798984', 'https://openalex.org/W1866160541', 'https://openalex.org/W1951795155', 'https://openalex.org/W1992436001', 'https://openalex.org/W2003982930', 'https://openalex.org/W2021790406', 'https://openalex.org/W2032194434', 'https://openalex.org/W2046403378', 'https://openalex.org/W2047084603', 'https://openalex.org/W2070828096', 'https://openalex.org/W2095417278', 'https://openalex.org/W2107116316', 'https://openalex.org/W2139852368', 'https://openalex.org/W2157950995', 'https://openalex.org/W2159237900', 'https://openalex.org/W2161633633', 'https://openalex.org/W2182104458', 'https://openalex.org/W2240430293', 'https://openalex.org/W2262279506', 'https://openalex.org/W2291794699', 'https://openalex.org/W2291968095', 'https://openalex.org/W2511515754', 'https://openalex.org/W2520288138', 'https://openalex.org/W2529241974', 'https://openalex.org/W2541285986', 'https://openalex.org/W2555190011', 'https://openalex.org/W2620763317', 'https://openalex.org/W2728946616', 'https://openalex.org/W2768987398', 'https://openalex.org/W2800035876', 'https://openalex.org/W2899390091', 'https://openalex.org/W2899645014', 'https://openalex.org/W2901476334', 'https://openalex.org/W2909754503', 'https://openalex.org/W2911396823', 'https://openalex.org/W2911487850', 'https://openalex.org/W2912654919', 'https://openalex.org/W2950375827', 'https://openalex.org/W2967846176', 'https://openalex.org/W2972423251', 'https://openalex.org/W2976906159', 'https://openalex.org/W2983607182', 'https://openalex.org/W2990377367', 'https://openalex.org/W3005398140', 'https://openalex.org/W3012042364', 'https://openalex.org/W3032468620', 'https://openalex.org/W3093747537', 'https://openalex.org/W3124601103', 'https://openalex.org/W3137375284', 'https://openalex.org/W3159902810', 'https://openalex.org/W3171833614', 'https://openalex.org/W4205105460', 'https://openalex.org/W4242652613', 'https://openalex.org/W4367051387'], 'related_works': ['https://openalex.org/W4387127397', 'https://openalex.org/W4321367679', 'https://openalex.org/W4318473195', 'https://openalex.org/W4248535037', 'https://openalex.org/W2937998792', 'https://openalex.org/W2618703495', 'https://openalex.org/W2557588769', 'https://openalex.org/W2549032866', 'https://openalex.org/W2256202175', 'https://openalex.org/W2061252706'], 'abstract_inverted_index': {'Abstract': [0], 'Treatment': [1], 'response': [2, 50, 113, 183, 201], 'and': [3, 42, 51, 64, 79, 92, 97, 111, 118, 144, 186, 223], 'resistance': [4, 41, 52, 124], 'in': [5, 19, 53, 86, 177, 220, 231, 243], 'major': [6], 'depressive': [7], 'disorder': [8], '(MDD)': [9], 'are': [10, 94], 'suggested': [11], 'to': [12, 16, 34, 43, 168, 203], 'be': [13], 'heritable.': [14], 'Due': [15], 'significant': [17, 175], 'challenges': [18], 'defining': [20], 'treatment-related': [21, 221], 'phenotypes,': [22], 'our': [23], 'understanding': [24], 'of': [25, 39, 62, 75, 109, 157, 181, 199, 217, 229], 'their': [26, 120, 141], 'genetic': [27, 46, 227, 238], 'bases': [28], 'is': [29], 'limited.': [30], 'This': [31, 233], 'study': [32], 'aimed': [33], 'derive': [35], 'a': [36, 174, 195, 237], 'stringent': [37], 'definition': [38], 'treatment': [40, 49, 96, 123], 'investigate': [44], 'the': [45, 60, 73, 145, 178, 215, 225], 'overlap': [47], 'between': [48, 184], 'MDD.': [54], 'Using': [55], 'electronic': [56], 'medical': [57], 'records': [58], 'on': [59], 'use': [61], 'antidepressants': [63, 91, 110, 139, 156], 'electroconvulsive': [65], 'therapy': [66], '(ECT)': [67], 'from': [68], 'Swedish': [69, 88], 'registers,': [70], 'we': [71, 103, 189], 'derived': [72], 'phenotype': [74], 'treatment-resistant': [76], 'depression': [77], '(TRD)': [78], 'non-TRD': [80, 204], 'within': [81], '~4500': [82], 'individuals': [83, 115], 'with': [84, 116, 122, 128], 'MDD': [85, 117, 133, 162], 'three': [87], 'cohorts.': [89], 'Considering': [90], 'lithium': [93, 112, 200, 241], 'first-line': [95], 'augmentation': [98], 'used': [99, 138], 'for': [100, 114, 240], 'MDD,': [101], 'respectively,': [102], 'generated': [104], 'polygenic': [105], 'risk': [106], 'scores': [107], '(PRS)': [108], 'evaluated': [119], 'associations': [121], 'by': [125], 'comparing': [126], 'TRD': [127, 185, 192], 'non-TRD.': [129], 'Among': [130], '1778': [131], 'ECT-treated': [132], 'cases,': [134], 'nearly': [135], 'all': [136], '(94%)': [137], 'before': [140], 'first': [142], 'ECT': [143, 165], 'vast': [146], 'majority': [147], 'had': [148, 194], 'at': [149], 'least': [150], 'one': [151], '(84%)': [152], 'or': [153], 'two': [154], '(61%)': [155], 'adequate': [158], 'duration,': [159], 'suggesting': [160], 'these': [161], 'cases': [163, 193, 205], 'receiving': [164], 'were': [166], 'resistant': [167], 'antidepressants.': [169], 'We': [170], 'did': [171], 'not': [172], 'observe': [173], 'difference': [176], 'mean': [179], 'PRS': [180, 198], 'antidepressant': [182], 'non-TRD;': [187], 'however,': [188], 'found': [190], 'that': [191], 'significantly': [196], 'higher': [197], 'compared': [202], '(OR': [206], '=': [207], '1.10–1.12': [208], 'under': [209], 'various': [210], 'definitions).': [211], 'The': [212], 'results': [213], 'support': [214], 'evidence': [216], 'heritable': [218], 'components': [219], 'phenotypes': [222], 'highlight': [224], 'overall': [226], 'profile': [228], 'lithium-sensitivity': [230], 'TRD.': [232, 245], 'finding': [234], 'further': [235], 'provides': [236], 'explanation': [239], 'efficacy': [242], 'treating': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4387127397', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}], 'updated_date': '2025-01-06T18:55:07.389379', 'created_date': '2023-09-29'}