Publication Information

{'id': 'https://openalex.org/W2341808732', 'doi': 'https://doi.org/10.1096/fasebj.27.1_supplement.1046.1', 'title': 'Role of DLC1 in Regulating Cellular and Focal Adhesion Dynamics', 'display_name': 'Role of DLC1 in Regulating Cellular and Focal Adhesion Dynamics', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2341808732', 'doi': 'https://doi.org/10.1096/fasebj.27.1_supplement.1046.1', 'mag': '2341808732'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.27.1_supplement.1046.1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077999999', 'display_name': 'Shelly Kaushik', 'orcid': 'https://orcid.org/0000-0002-8967-3265'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Shelly Kaushik', 'raw_affiliation_strings': ['Biological Sciences, National University of Singapore, Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Biological Sciences, National University of Singapore, Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055998574', 'display_name': 'Boon Chuan Low', 'orcid': 'https://orcid.org/0000-0003-0756-096X'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Boon Chuan Low', 'raw_affiliation_strings': ['Biological Sciences, National University of Singapore, Singapore, Singapore', 'Mechanobiology Institute, Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Mechanobiology Institute, Singapore, Singapore', 'institution_ids': []}, {'raw_affiliation_string': 'Biological Sciences, National University of Singapore, Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '27', 'issue': 'S1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/paxillin', 'display_name': 'Paxillin', 'score': 0.8769268}, {'id': 'https://openalex.org/keywords/cdc42', 'display_name': 'CDC42', 'score': 0.763843}], 'concepts': [{'id': 'https://openalex.org/C151166631', 'wikidata': 'https://www.wikidata.org/wiki/Q904514', 'display_name': 'Focal adhesion', 'level': 3, 'score': 0.97665304}, {'id': 'https://openalex.org/C2777093181', 'wikidata': 'https://www.wikidata.org/wiki/Q15331450', 'display_name': 'RHOA', 'level': 3, 'score': 0.93530226}, {'id': 'https://openalex.org/C116581196', 'wikidata': 'https://www.wikidata.org/wiki/Q14906591', 'display_name': 'Paxillin', 'level': 4, 'score': 0.8769268}, {'id': 'https://openalex.org/C2780040266', 'wikidata': 'https://www.wikidata.org/wiki/Q15311701', 'display_name': 'CDC42', 'level': 3, 'score': 0.763843}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.7565064}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.66476136}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.564514}, {'id': 'https://openalex.org/C121381206', 'wikidata': 'https://www.wikidata.org/wiki/Q902514', 'display_name': 'Total internal reflection fluorescence microscope', 'level': 3, 'score': 0.5489021}, {'id': 'https://openalex.org/C84416704', 'wikidata': 'https://www.wikidata.org/wiki/Q188666', 'display_name': 'Adhesion', 'level': 2, 'score': 0.5004289}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39093465}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38719422}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.35911763}, {'id': 'https://openalex.org/C207332259', 'wikidata': 'https://www.wikidata.org/wiki/Q769143', 'display_name': 'GTPase', 'level': 2, 'score': 0.34764785}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.16181362}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12879935}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.27.1_supplement.1046.1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4318754196', 'https://openalex.org/W4220838032', 'https://openalex.org/W2366732641', 'https://openalex.org/W2165915920', 'https://openalex.org/W2157380902', 'https://openalex.org/W2126892899', 'https://openalex.org/W2083971379', 'https://openalex.org/W2052164164', 'https://openalex.org/W1512868117', 'https://openalex.org/W1504013411'], 'abstract_inverted_index': {'Deleted': [0], 'in': [1, 12, 124, 134, 151], 'Liver': [2], 'Cancer‐1': [3], '(DLC1)': [4], 'is': [5, 10, 67], 'a': [6, 13, 125, 135, 147], 'RhoGTPase‐activating': [7], 'protein': [8], 'that': [9, 119], 'down‐regulated': [11], 'number': [14], 'of': [15, 87, 160, 186, 203], 'cancers.': [16], 'It': [17], 'specifically': [18], 'acts': [19], 'on': [20, 32, 64, 89, 193], 'RhoA': [21, 187], 'and': [22, 45, 60, 79, 92, 95, 99, 106, 157, 172, 201], 'to': [23, 39, 41, 49, 109, 141, 165], 'some': [24], 'extent': [25], 'Cdc42,': [26], 'but': [27], 'has': [28, 36], 'no': [29], 'discernible': [30], 'effect': [31, 63, 86], 'Rac1': [33], 'activity.': [34], 'DLC1': [35, 88, 120, 138, 179], 'been': [37], 'shown': [38], 'localize': [40], 'the': [42, 57, 85, 152], 'focal': [43, 58, 102, 104, 153, 166, 194], 'adhesions': [44, 59, 105, 108, 154], 'its': [46, 54, 61, 97, 184, 191], 'absence': [47], 'leads': [48], 'enhanced': [50], 'cell': [51, 65, 90, 93, 122, 132, 161], 'migration.': [52], 'However,': [53], 'role': [55], 'at': [56, 101], 'subsequent': [62], 'migration': [66, 91, 133], 'still': [68], 'unclear.': [69], 'Using': [70], 'immunofluorescence': [71], 'techniques,': [72], 'Total': [73], 'Internal': [74], 'Reflection': [75], 'Fluorescence': [76], 'Microscopy': [77], '(TIRFM)': [78], 'quantitative': [80], 'image': [81], 'analysis': [82], 'we': [83], 'examined': [84], 'spreading': [94, 123, 162], 'determined': [96], 'localization': [98], 'dynamics': [100, 114, 182], 'complexes,': [103], 'fibrillar': [107], 'understand': [110], 'how': [111], 'these': [112], 'cellular': [113, 181], 'are': [115], 'affected.': [116], 'We': [117], 'found': [118], 'inhibits': [121, 131], 'RhoA‐dependent,': [126], 'substrate‐independent': [127], 'manner': [128], 'whereas': [129], 'it': [130], 'RhoA‐independent': [136], 'manner.': [137], 'also': [139], 'localizes': [140], 'all': [142], 'three': [143], 'adhesion': [144, 167, 195], 'types,': [145], 'with': [146], 'specific': [148], 'spatial': [149], 'distribution': [150], 'during': [155], 'early': [156], 'late': [158], 'stages': [159], 'when': [163], 'compared': [164], 'proteins': [168], 'such': [169], 'as': [170, 188, 190], 'paxillin': [171], 'Focal': [173], 'Adhesion': [174], 'Kinase': [175], '(FAK).': [176], 'In': [177], 'summary,': [178], 'regulates': [180], 'by': [183, 198], 'down‐regulation': [185], 'well': [189], 'effects': [192], 'dynamics.': [196], 'Supported': [197], 'Mechanobiology': [199], 'Institute': [200], 'Ministry': [202], 'Education,': [204], 'Singapore': [205], '(Academic': [206], 'Research': [207], 'Fund': [208], 'T208A3121)': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2341808732', 'counts_by_year': [], 'updated_date': '2024-12-13T16:50:09.478601', 'created_date': '2016-06-24'}