Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2337606069', 'doi': 'https://doi.org/10.1126/science.aad9279', 'title': 'Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes', 'display_name': 'Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes', 'publication_year': 2016, 'publication_date': '2016-04-14', 'ids': {'openalex': 'https://openalex.org/W2337606069', 'doi': 'https://doi.org/10.1126/science.aad9279', 'mag': '2337606069', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27081071', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5149070'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/science.aad9279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1126/science.aad9279', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013096500', 'display_name': 'C.D. Goodman', 'orcid': 'https://orcid.org/0000-0002-8923-7594'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Christopher D. Goodman', 'raw_affiliation_strings': ['School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082990388', 'display_name': 'Josephine Elizabeth Siregar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I2800477803', 'display_name': 'Eijkman Institute for Molecular Biology', 'ror': 'https://ror.org/0308s4091', 'country_code': 'ID', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800477803']}], 'countries': ['AU', 'ID', 'JP'], 'is_corresponding': False, 'raw_author_name': 'Josephine E. Siregar', 'raw_affiliation_strings': ['Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.', 'Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.', 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}, {'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}, {'raw_affiliation_string': 'Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.', 'institution_ids': ['https://openalex.org/I2800477803']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050115986', 'display_name': 'Vanessa Mollard', 'orcid': 'https://orcid.org/0000-0001-9222-8229'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Vanessa Mollard', 'raw_affiliation_strings': ['School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041012117', 'display_name': 'Joel Vega-Rodríguez', 'orcid': 'https://orcid.org/0000-0002-9576-0058'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joel Vega-Rodríguez', 'raw_affiliation_strings': ['Johns Hopkins University Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA.'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068758926', 'display_name': 'Din Syafruddin', 'orcid': 'https://orcid.org/0000-0001-7141-2545'}, 'institutions': [{'id': 'https://openalex.org/I98301867', 'display_name': 'Hasanuddin University', 'ror': 'https://ror.org/00da1gf19', 'country_code': 'ID', 'type': 'education', 'lineage': ['https://openalex.org/I98301867']}, {'id': 'https://openalex.org/I2800477803', 'display_name': 'Eijkman Institute for Molecular Biology', 'ror': 'https://ror.org/0308s4091', 'country_code': 'ID', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800477803']}], 'countries': ['ID'], 'is_corresponding': False, 'raw_author_name': 'Din Syafruddin', 'raw_affiliation_strings': ['Department of Parasitology, Faculty of Medicine, Hasanuddin University, Jalan Perintis Kemerdekaan Km10, Makassar 90245, Indonesia.', 'Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.'], 'affiliations': [{'raw_affiliation_string': 'Department of Parasitology, Faculty of Medicine, Hasanuddin University, Jalan Perintis Kemerdekaan Km10, Makassar 90245, Indonesia.', 'institution_ids': ['https://openalex.org/I98301867']}, {'raw_affiliation_string': 'Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.', 'institution_ids': ['https://openalex.org/I2800477803']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056033690', 'display_name': 'Hiroyuki Matsuoka', 'orcid': 'https://orcid.org/0000-0001-8839-0012'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroyuki Matsuoka', 'raw_affiliation_strings': ['Division of Medical Zoology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Zoology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029823593', 'display_name': 'Motomichi Matsuzaki', 'orcid': 'https://orcid.org/0000-0001-5811-798X'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Motomichi Matsuzaki', 'raw_affiliation_strings': ['Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113548539', 'display_name': 'T. Toyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Tomoko Toyama', 'raw_affiliation_strings': ['School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017098545', 'display_name': 'Angelika Sturm', 'orcid': 'https://orcid.org/0000-0003-0051-6800'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Angelika Sturm', 'raw_affiliation_strings': ['School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077542365', 'display_name': 'Anton Cozijnsen', 'orcid': 'https://orcid.org/0000-0002-2763-2927'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Anton Cozijnsen', 'raw_affiliation_strings': ['School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001978382', 'display_name': 'Marcelo Jacobs‐Lorena', 'orcid': 'https://orcid.org/0000-0003-0449-432X'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marcelo Jacobs-Lorena', 'raw_affiliation_strings': ['Johns Hopkins University Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA.'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072986768', 'display_name': 'Kiyoshi Kita', 'orcid': 'https://orcid.org/0000-0002-0426-4308'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}, {'id': 'https://openalex.org/I43777268', 'display_name': 'Nagasaki University', 'ror': 'https://ror.org/058h74p94', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43777268']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kiyoshi Kita', 'raw_affiliation_strings': ['Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.', 'School of Tropical Medicine and Global Health, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.', 'institution_ids': ['https://openalex.org/I74801974']}, {'raw_affiliation_string': 'School of Tropical Medicine and Global Health, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan.', 'institution_ids': ['https://openalex.org/I43777268']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008902641', 'display_name': 'Sangkot Marzuki', 'orcid': 'https://orcid.org/0000-0003-1104-4300'}, 'institutions': [{'id': 'https://openalex.org/I2800477803', 'display_name': 'Eijkman Institute for Molecular Biology', 'ror': 'https://ror.org/0308s4091', 'country_code': 'ID', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800477803']}], 'countries': ['ID'], 'is_corresponding': False, 'raw_author_name': 'Sangkot Marzuki', 'raw_affiliation_strings': ['Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.'], 'affiliations': [{'raw_affiliation_string': 'Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.', 'institution_ids': ['https://openalex.org/I2800477803']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051844096', 'display_name': 'Geoffrey I. McFadden', 'orcid': 'https://orcid.org/0000-0002-5351-1627'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Geoffrey I. McFadden', 'raw_affiliation_strings': ['School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.'], 'affiliations': [{'raw_affiliation_string': 'School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 16.585, 'has_fulltext': False, 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.999977, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '352', 'issue': '6283', 'first_page': '349', 'last_page': '353'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9823, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atovaquone', 'display_name': 'Atovaquone', 'score': 0.9793266}], 'concepts': [{'id': 'https://openalex.org/C2779124865', 'wikidata': 'https://www.wikidata.org/wiki/Q418179', 'display_name': 'Atovaquone', 'level': 4, 'score': 0.9793266}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.77334493}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.7498282}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.5427641}, {'id': 'https://openalex.org/C71928629', 'wikidata': 'https://www.wikidata.org/wiki/Q804206', 'display_name': 'Parasite hosting', 'level': 2, 'score': 0.5033631}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.4641885}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.36132625}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.32192096}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.19533432}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000852', 'descriptor_name': 'Anopheles', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': True}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D053626', 'descriptor_name': 'Atovaquone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D045303', 'descriptor_name': 'Cytochromes b', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010962', 'descriptor_name': 'Plasmodium berghei', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000852', 'descriptor_name': 'Anopheles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053626', 'descriptor_name': 'Atovaquone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D053626', 'descriptor_name': 'Atovaquone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045303', 'descriptor_name': 'Cytochromes b', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050259', 'descriptor_name': 'Genes, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050259', 'descriptor_name': 'Genes, Mitochondrial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008018', 'descriptor_name': 'Life Cycle Stages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008018', 'descriptor_name': 'Life Cycle Stages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008018', 'descriptor_name': 'Life Cycle Stages', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000635', 'qualifier_name': 'transmission', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010962', 'descriptor_name': 'Plasmodium berghei', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010962', 'descriptor_name': 'Plasmodium berghei', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D010962', 'descriptor_name': 'Plasmodium berghei', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012641', 'descriptor_name': 'Selection, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/science.aad9279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5149070', 'pdf_url': 'https://europepmc.org/articles/pmc5149070?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149070', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27081071', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/science.aad9279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320320212', 'funder_display_name': 'Japan Society for the Promotion of Science London', 'award_id': '23117004'}, {'funder': 'https://openalex.org/F4320320212', 'funder_display_name': 'Japan Society for the Promotion of Science London', 'award_id': '26253025'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'AI031478'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'RR00052'}, {'funder': 'https://openalex.org/F4320334704', 'funder_display_name': 'Australian Research Council', 'award_id': None}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1966553905', 'https://openalex.org/W1969503178', 'https://openalex.org/W1976977157', 'https://openalex.org/W1977823618', 'https://openalex.org/W1981783356', 'https://openalex.org/W1982278524', 'https://openalex.org/W1984674906', 'https://openalex.org/W1995421796', 'https://openalex.org/W2002763552', 'https://openalex.org/W2007561244', 'https://openalex.org/W2009082036', 'https://openalex.org/W2023224492', 'https://openalex.org/W2031821124', 'https://openalex.org/W2038073476', 'https://openalex.org/W2055044745', 'https://openalex.org/W2069220164', 'https://openalex.org/W2079105656', 'https://openalex.org/W2080430126', 'https://openalex.org/W2080689553', 'https://openalex.org/W2095745314', 'https://openalex.org/W2112477725', 'https://openalex.org/W2114296160', 'https://openalex.org/W2114818342', 'https://openalex.org/W2133236892', 'https://openalex.org/W2137062868', 'https://openalex.org/W2138488546', 'https://openalex.org/W2139271485', 'https://openalex.org/W2140066802', 'https://openalex.org/W2140582889', 'https://openalex.org/W2141796235', 'https://openalex.org/W2145537179', 'https://openalex.org/W2147775888', 'https://openalex.org/W2155904118', 'https://openalex.org/W2161278878', 'https://openalex.org/W2164678187', 'https://openalex.org/W2167552649', 'https://openalex.org/W2167970645', 'https://openalex.org/W2171102256', 'https://openalex.org/W2326452262', 'https://openalex.org/W4248670775'], 'related_works': ['https://openalex.org/W4360616009', 'https://openalex.org/W3169338074', 'https://openalex.org/W2516822342', 'https://openalex.org/W2411203700', 'https://openalex.org/W2402180649', 'https://openalex.org/W2171509350', 'https://openalex.org/W2113991941', 'https://openalex.org/W2050201605', 'https://openalex.org/W1995852503', 'https://openalex.org/W1986570001'], 'abstract_inverted_index': {'Transmission': [0], 'blocked': [1], 'by': [2], 'drug': [3, 9], 'resistance': [4], 'Resistance': [5, 19], 'to': [6, 13, 61, 86], 'the': [7, 25, 28, 52], 'antimalarial': [8], 'atovaquone': [10], 'might': [11], 'prove': [12], 'be': [14, 69, 84], 'this': [15, 93], "parasite's": [16, 29], 'weak': [17], 'spot.': [18], 'develops': [20], 'rapidly': [21], 'via': [22], 'mutations': [23, 53], 'in': [24, 46, 48, 72], "drug's": [26], 'target:': [27], 'mitochondrial': [30], 'cytochrome': [31], 'b': [32], 'complex.': [33], 'Goodman': [34], 'et': [35], 'al.': [36], 'have': [37], 'discovered': [38], 'that': [39], 'although': [40], 'resistant': [41], 'Plasmodium': [42, 65], 'berghei': [43], 'parasites': [44, 56, 82], 'persist': [45], 'mice,': [47], 'blood-sucking': [49], 'malarial': [50], 'mosquitoes,': [51, 73], 'disable': [54], 'female': [55], 'too': [57], 'much': [58], 'for': [59], 'them': [60], 'reproduce.': [62], 'The': [63], 'human-specific': [64], 'falciparum': [66], 'can': [67], 'only': [68], 'investigated': [70], 'experimentally': [71], 'but': [74], 'a': [75], 'similar': [76], 'effect': [77], 'was': [78], 'seen.': [79], 'Thus,': [80], 'atovaquone-resistant': [81], 'cannot': [83], 'transmitted': [85], 'another': [87], 'mammal': [88], 'or': [89], 'person.': [90], 'Science': [91], ',': [92], 'issue': [94], 'p.': [95], '349': [96]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2337606069', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 9}], 'updated_date': '2024-12-25T11:34:32.246864', 'created_date': '2016-06-24'}