Title: THE CLINICO-PATHOLOGICAL STUDY OF HEPATOCELLULAR CARCINOMA, UNACCOMPANIED BY LIVER CIRRHOSIS
Abstract: In 100 patients with hepatocellular carcinoma (HCC), 79 cases were accompanied by liver cirrhosis and 21 cases were not. In the accompanied (A) and unaccompanied (B) groups by liver cirrhosis, there was no differences about sex, alcohol intake, the serum level of alpha-fetoprotein. B group was widely distributed from 20 to 80 years old in age and more rarely had the history of blood transfusion than A group. The family history of liver disease and the rate of positive HBsAg were frequently observed in B group than A group. Though B group was found in advanced state with subjective and objective symptoms, there was no difference in prognosis between the two groups. The histology of the non-cancerous lesions of the B group included 2 cases of portal fibrosis, 7 cases of chronic active hepatitis, one case of non specific changes. Two young patients under 40 years old of B group were both HBsAg positive, so it seemed to be necessary for HBsAg carriers without liver cirrhosis to be screened as high risk group of HCC.