Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2325287326', 'doi': 'https://doi.org/10.1038/ncb3335', 'title': 'HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth', 'display_name': 'HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth', 'publication_year': 2016, 'publication_date': '2016-04-04', 'ids': {'openalex': 'https://openalex.org/W2325287326', 'doi': 'https://doi.org/10.1038/ncb3335', 'mag': '2325287326', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27043084', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5341796'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/ncb3335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5341796?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052999889', 'display_name': 'Kuo‐Hui Su', 'orcid': 'https://orcid.org/0000-0002-0834-8568'}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kuo-Hui Su', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022715650', 'display_name': 'Junyue Cao', 'orcid': 'https://orcid.org/0000-0003-4097-489X'}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Junyue Cao', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020509507', 'display_name': 'Zijian Tang', 'orcid': 'https://orcid.org/0000-0002-0888-9217'}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zijian Tang', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011552393', 'display_name': 'Siyuan Dai', 'orcid': 'https://orcid.org/0000-0002-4062-5211'}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Siyuan Dai', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043811047', 'display_name': 'Yishu He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yishu He', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072939364', 'display_name': 'Stephen B. Sampson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen Byers Sampson', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004573225', 'display_name': 'Ivor J. Benjamin', 'orcid': 'https://orcid.org/0000-0003-3310-3957'}, 'institutions': [{'id': 'https://openalex.org/I204308271', 'display_name': 'Medical College of Wisconsin', 'ror': 'https://ror.org/00qqv6244', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204308271']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ivor J. Benjamin', 'raw_affiliation_strings': ['Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA', 'institution_ids': ['https://openalex.org/I204308271']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047359909', 'display_name': 'Chengkai Dai', 'orcid': 'https://orcid.org/0000-0001-8520-1036'}, 'institutions': [{'id': 'https://openalex.org/I4210115256', 'display_name': 'Jackson Laboratory', 'ror': 'https://ror.org/021sy4w91', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210115256']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chengkai Dai', 'raw_affiliation_strings': ['The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA'], 'affiliations': [{'raw_affiliation_string': 'The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA', 'institution_ids': ['https://openalex.org/I4210115256']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.157, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 90, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '5', 'first_page': '527', 'last_page': '539'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9828, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hsf1', 'display_name': 'HSF1', 'score': 0.8907399}, {'id': 'https://openalex.org/keywords/cellular-adaptation', 'display_name': 'Cellular adaptation', 'score': 0.66633266}, {'id': 'https://openalex.org/keywords/cellular-stress-response', 'display_name': 'Cellular stress response', 'score': 0.5176328}], 'concepts': [{'id': 'https://openalex.org/C98490376', 'wikidata': 'https://www.wikidata.org/wiki/Q14876060', 'display_name': 'mTORC1', 'level': 4, 'score': 0.94093513}, {'id': 'https://openalex.org/C2776667301', 'wikidata': 'https://www.wikidata.org/wiki/Q18027324', 'display_name': 'HSF1', 'level': 5, 'score': 0.8907399}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.73965645}, {'id': 'https://openalex.org/C156902634', 'wikidata': 'https://www.wikidata.org/wiki/Q5058346', 'display_name': 'Cellular adaptation', 'level': 3, 'score': 0.66633266}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5979502}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.58544654}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.5505283}, {'id': 'https://openalex.org/C2780096491', 'wikidata': 'https://www.wikidata.org/wiki/Q60574533', 'display_name': 'Cellular stress response', 'level': 4, 'score': 0.5176328}, {'id': 'https://openalex.org/C137984847', 'wikidata': 'https://www.wikidata.org/wiki/Q1621258', 'display_name': 'Heat shock', 'level': 4, 'score': 0.4633565}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.37490356}, {'id': 'https://openalex.org/C205260736', 'wikidata': 'https://www.wikidata.org/wiki/Q418939', 'display_name': 'Heat shock protein', 'level': 3, 'score': 0.26198614}, {'id': 'https://openalex.org/C78604142', 'wikidata': 'https://www.wikidata.org/wiki/Q1640582', 'display_name': 'Fight-or-flight response', 'level': 3, 'score': 0.17726916}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16779196}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.13884217}, {'id': 'https://openalex.org/C68991219', 'wikidata': 'https://www.wikidata.org/wiki/Q419102', 'display_name': 'Hsp70', 'level': 4, 'score': 0.13593543}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06263515}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018869', 'descriptor_name': 'Heat-Shock Response', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049628', 'descriptor_name': 'Body Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049628', 'descriptor_name': 'Body Size', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D048429', 'descriptor_name': 'Cell Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048429', 'descriptor_name': 'Cell Size', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076249', 'descriptor_name': 'Heat Shock Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018869', 'descriptor_name': 'Heat-Shock Response', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000076222', 'descriptor_name': 'Mechanistic Target of Rapamycin Complex 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/ncb3335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5341796', 'pdf_url': 'https://europepmc.org/articles/pmc5341796?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341796', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27043084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5341796', 'pdf_url': 'https://europepmc.org/articles/pmc5341796?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1523693806', 'https://openalex.org/W1572174728', 'https://openalex.org/W1964184380', 'https://openalex.org/W1970637701', 'https://openalex.org/W1976643149', 'https://openalex.org/W1981975569', 'https://openalex.org/W1984054751', 'https://openalex.org/W1984903682', 'https://openalex.org/W1985554302', 'https://openalex.org/W1995856733', 'https://openalex.org/W1999769203', 'https://openalex.org/W2001568034', 'https://openalex.org/W2001569984', 'https://openalex.org/W2003013566', 'https://openalex.org/W2004582874', 'https://openalex.org/W2006559495', 'https://openalex.org/W2019041692', 'https://openalex.org/W2023012828', 'https://openalex.org/W2025176940', 'https://openalex.org/W2026265704', 'https://openalex.org/W2027785297', 'https://openalex.org/W2028321505', 'https://openalex.org/W2031793125', 'https://openalex.org/W2032189193', 'https://openalex.org/W2035789545', 'https://openalex.org/W2038018821', 'https://openalex.org/W2053479303', 'https://openalex.org/W2053560001', 'https://openalex.org/W2056218982', 'https://openalex.org/W2060902443', 'https://openalex.org/W2069030183', 'https://openalex.org/W2076159058', 'https://openalex.org/W2081920342', 'https://openalex.org/W2086402424', 'https://openalex.org/W2089375954', 'https://openalex.org/W2090926709', 'https://openalex.org/W2098816844', 'https://openalex.org/W2109709409', 'https://openalex.org/W2112242064', 'https://openalex.org/W2112425781', 'https://openalex.org/W2112738731', 'https://openalex.org/W2115527176', 'https://openalex.org/W2117002197', 'https://openalex.org/W2119979409', 'https://openalex.org/W2121000910', 'https://openalex.org/W2127063807', 'https://openalex.org/W2127646238', 'https://openalex.org/W2132051882', 'https://openalex.org/W2132296982', 'https://openalex.org/W2146156391', 'https://openalex.org/W2146781227', 'https://openalex.org/W2146965545', 'https://openalex.org/W2150715002', 'https://openalex.org/W2154799239', 'https://openalex.org/W2157360354', 'https://openalex.org/W2159294242', 'https://openalex.org/W2163583831', 'https://openalex.org/W2165113979', 'https://openalex.org/W2166307667', 'https://openalex.org/W2166440816', 'https://openalex.org/W2168431125', 'https://openalex.org/W2168980975', 'https://openalex.org/W2170444099'], 'related_works': ['https://openalex.org/W3105788470', 'https://openalex.org/W2803732764', 'https://openalex.org/W2325287326', 'https://openalex.org/W2154512403', 'https://openalex.org/W2135093278', 'https://openalex.org/W2132664329', 'https://openalex.org/W2102042089', 'https://openalex.org/W2044482971', 'https://openalex.org/W2015640955', 'https://openalex.org/W1989635548'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2325287326', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 21}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-19T18:48:45.333866', 'created_date': '2016-06-24'}