Publication Information

{'id': 'https://openalex.org/W2323279270', 'doi': 'https://doi.org/10.2174/092986711796504619', 'title': 'Diketo Acids Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain', 'display_name': 'Diketo Acids Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain', 'publication_year': 2011, 'publication_date': '2011-07-25', 'ids': {'openalex': 'https://openalex.org/W2323279270', 'doi': 'https://doi.org/10.2174/092986711796504619', 'mag': '2323279270', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21728968'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986711796504619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045870972', 'display_name': 'Roberto Di Santo', 'orcid': 'https://orcid.org/0000-0002-4279-7666'}, 'institutions': [{'id': 'https://openalex.org/I4210153523', 'display_name': 'Istituto Pasteur', 'ror': 'https://ror.org/051v7w268', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210153523']}, {'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'R. Di Santo', 'raw_affiliation_strings': ['Pasteur Institute - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” University of Rome, P.le Aldo Moro 5, I-00185 Rome, Italy.,Italy'], 'affiliations': [{'raw_affiliation_string': 'Pasteur Institute - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” University of Rome, P.le Aldo Moro 5, I-00185 Rome, Italy.,Italy', 'institution_ids': ['https://openalex.org/I4210153523', 'https://openalex.org/I861853513']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5045870972'], 'corresponding_institution_ids': ['https://openalex.org/I4210153523', 'https://openalex.org/I861853513'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.417, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.611535, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '18', 'issue': '22', 'first_page': '3335', 'last_page': '3342'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rnase-h', 'display_name': 'RNase H', 'score': 0.92859715}], 'concepts': [{'id': 'https://openalex.org/C69766542', 'wikidata': 'https://www.wikidata.org/wiki/Q3430179', 'display_name': 'RNase H', 'level': 5, 'score': 0.92859715}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.822718}, {'id': 'https://openalex.org/C14430832', 'wikidata': 'https://www.wikidata.org/wiki/Q412550', 'display_name': 'Integrase', 'level': 3, 'score': 0.8145362}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5586705}, {'id': 'https://openalex.org/C2756471', 'wikidata': 'https://www.wikidata.org/wiki/Q206286', 'display_name': 'DNA polymerase', 'level': 3, 'score': 0.54097384}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.517474}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.49953222}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.462456}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.42169508}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4009917}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.36775863}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07654446}], 'mesh': [{'descriptor_ui': 'D019428', 'descriptor_name': 'HIV Integrase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D054303', 'descriptor_name': 'HIV Reverse Transcriptase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D007651', 'descriptor_name': 'Keto Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D016914', 'descriptor_name': 'Ribonuclease H', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D019428', 'descriptor_name': 'HIV Integrase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054303', 'descriptor_name': 'HIV Reverse Transcriptase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007651', 'descriptor_name': 'Keto Acids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007651', 'descriptor_name': 'Keto Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016914', 'descriptor_name': 'Ribonuclease H', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986711796504619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21728968', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1519899019', 'https://openalex.org/W1581899877', 'https://openalex.org/W161726719', 'https://openalex.org/W1833342122', 'https://openalex.org/W1851303894', 'https://openalex.org/W1967309605', 'https://openalex.org/W1970101581', 'https://openalex.org/W1970850106', 'https://openalex.org/W1994957764', 'https://openalex.org/W2002297065', 'https://openalex.org/W2006212265', 'https://openalex.org/W2006260411', 'https://openalex.org/W2007831756', 'https://openalex.org/W2008408466', 'https://openalex.org/W2009443607', 'https://openalex.org/W2010533762', 'https://openalex.org/W2014066420', 'https://openalex.org/W2017173005', 'https://openalex.org/W2021871669', 'https://openalex.org/W2021944591', 'https://openalex.org/W2025757251', 'https://openalex.org/W2027704006', 'https://openalex.org/W2028094900', 'https://openalex.org/W2028315493', 'https://openalex.org/W2028344177', 'https://openalex.org/W2033368634', 'https://openalex.org/W2034738181', 'https://openalex.org/W2050472095', 'https://openalex.org/W2053125329', 'https://openalex.org/W2054025309', 'https://openalex.org/W2059849077', 'https://openalex.org/W2061055243', 'https://openalex.org/W2066461326', 'https://openalex.org/W2081237483', 'https://openalex.org/W2084426324', 'https://openalex.org/W2087400133', 'https://openalex.org/W2090946777', 'https://openalex.org/W2097471240', 'https://openalex.org/W2101038612', 'https://openalex.org/W2106635136', 'https://openalex.org/W2108841553', 'https://openalex.org/W2113202468', 'https://openalex.org/W2113428012', 'https://openalex.org/W2117959947', 'https://openalex.org/W2127484412', 'https://openalex.org/W2131769180', 'https://openalex.org/W2135503719', 'https://openalex.org/W2140534639', 'https://openalex.org/W2142308857', 'https://openalex.org/W2143374044', 'https://openalex.org/W2151465576', 'https://openalex.org/W2152343731', 'https://openalex.org/W2157887699', 'https://openalex.org/W2160982073', 'https://openalex.org/W2165978291', 'https://openalex.org/W2167082358', 'https://openalex.org/W2171711893', 'https://openalex.org/W2987948438', 'https://openalex.org/W58170104'], 'related_works': ['https://openalex.org/W2473881623', 'https://openalex.org/W2411448052', 'https://openalex.org/W2223456698', 'https://openalex.org/W2096839398', 'https://openalex.org/W2086402826', 'https://openalex.org/W2056460200', 'https://openalex.org/W2012370202', 'https://openalex.org/W201075604', 'https://openalex.org/W1994957764', 'https://openalex.org/W1977599839'], 'abstract_inverted_index': {'The': [0, 66, 157], 'HIV-1': [1, 92], 'integrase': [2], '(IN)': [3], 'and': [4, 53, 58, 60, 95, 110, 128, 138, 165, 171], 'reverse': [5], 'transcriptase': [6], '(RT)': [7], 'are': [8, 97, 169], 'essential': [9], 'enzymes': [10], 'in': [11, 30, 33, 99, 136], 'the': [12, 19, 22, 31, 37, 51, 61, 71, 75, 79, 85, 112, 147, 160], 'virus': [13], 'cycle.': [14], 'RT': [15], 'is': [16, 28], 'crucial': [17], 'for': [18, 118], 'retrotranscription': [20], 'of': [21, 36, 74, 78, 90, 140, 149, 159], 'RNA': [23, 76], 'viral': [24], 'genome,': [25], 'while': [26], 'IN': [27, 96, 127, 141], 'involved': [29], 'insertion': [32], 'host': [34], 'chromosome': [35], 'proviral': [38], 'double': [39], 'strand': [40, 77], 'DNA': [41, 55], 'produced': [42], 'by': [43, 163], 'RT.': [44], 'This': [45], 'enzyme': [46], 'has': [47], 'two': [48], 'associated': [49], 'functions:': [50], 'RNA-': [52], 'DNA-dependent': [54], 'polymerase': [56], '(RDDP': [57], 'DDDP)': [59], 'ribonuclease': [62], 'H': [63, 68, 94, 130, 155], '(RNase': [64], 'H).': [65], 'RNase': [67, 93, 129, 154], 'function': [69], 'catalyzes': [70], 'selective': [72], 'hydrolysis': [73], 'RNA:DNA': [80], 'heteroduplex': [81], 'replication': [82], 'intermediate.': [83], 'Since': [84], 'discovery': [86], 'that': [87], 'catalytic': [88, 119], 'cores': [89], 'both': [91], 'folded': [98], 'a': [100], 'very': [101, 105], 'similar': [102, 106], 'way,': [103], 'have': [104], 'active': [107], 'site': [108], 'geometries,': [109], 'show': [111], 'same': [113], 'DDE': [114], 'triad': [115], 'absolutely': [116], 'required': [117], 'activity,': [120], 'some': [121], 'researches': [122], 'were': [123], 'devoted': [124], 'to': [125, 145], 'study': [126, 146], 'dual': [131], 'inhibitor.': [132], 'Our': [133], 'decennial': [134], 'interest': [135], 'design': [137], 'synthesis': [139], 'inhibitors': [142], 'led': [143], 'us': [144], 'activity': [148], 'our': [150], 'compounds': [151], 'also': [152], 'on': [153], 'activity.': [156], 'results': [158], 'activities': [161], 'showed': [162], 'pyrrolyl': [164], 'quinolonyl': [166], 'diketo': [167], 'acids': [168], 'reported': [170], 'discussed.': [172]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2323279270', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-16T13:44:37.789959', 'created_date': '2016-06-24'}