Publication Information

{'id': 'https://openalex.org/W2086402826', 'doi': 'https://doi.org/10.1128/aac.34.10.2009', 'title': 'Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase', 'display_name': 'Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase', 'publication_year': 1990, 'publication_date': '1990-10-01', 'ids': {'openalex': 'https://openalex.org/W2086402826', 'doi': 'https://doi.org/10.1128/aac.34.10.2009', 'mag': '2086402826', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1705412', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/171980'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.34.10.2009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc171980?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113596473', 'display_name': 'Shoshana Loya', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'S Loya', 'raw_affiliation_strings': ['Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109416355', 'display_name': 'R. Tal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'R Tal', 'raw_affiliation_strings': ['Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060600887', 'display_name': 'Yoel Kashman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Y Kashman', 'raw_affiliation_strings': ['Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049821570', 'display_name': 'Amnon Hizi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'A Hizi', 'raw_affiliation_strings': ['Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv, Israel.', 'institution_ids': ['https://openalex.org/I16391192']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.979, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 114, 'citation_normalized_percentile': {'value': 0.951338, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '34', 'issue': '10', 'first_page': '2009', 'last_page': '2012'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rnase-h', 'display_name': 'RNase H', 'score': 0.87383586}, {'id': 'https://openalex.org/keywords/rna-directed-dna-polymerase', 'display_name': 'RNA-Directed DNA Polymerase', 'score': 0.57051736}], 'concepts': [{'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.9167547}, {'id': 'https://openalex.org/C69766542', 'wikidata': 'https://www.wikidata.org/wiki/Q3430179', 'display_name': 'RNase H', 'level': 5, 'score': 0.87383586}, {'id': 'https://openalex.org/C2756471', 'wikidata': 'https://www.wikidata.org/wiki/Q206286', 'display_name': 'DNA polymerase', 'level': 3, 'score': 0.7124978}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.6131196}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.6117184}, {'id': 'https://openalex.org/C2910803801', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'RNA-Directed DNA Polymerase', 'level': 5, 'score': 0.57051736}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.56782615}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.54219913}, {'id': 'https://openalex.org/C10879258', 'wikidata': 'https://www.wikidata.org/wiki/Q76826611', 'display_name': 'RNase P', 'level': 4, 'score': 0.52397627}, {'id': 'https://openalex.org/C2780216070', 'wikidata': 'https://www.wikidata.org/wiki/Q198504', 'display_name': 'Zidovudine', 'level': 4, 'score': 0.5136056}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47240514}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.45745838}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.4217388}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.39828736}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3982355}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3532299}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.106642544}, {'id': 'https://openalex.org/C2780727368', 'wikidata': 'https://www.wikidata.org/wiki/Q1928978', 'display_name': 'Viral disease', 'level': 3, 'score': 0.066040516}], 'mesh': [{'descriptor_ui': 'D004722', 'descriptor_name': 'Endoribonucleases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D006678', 'descriptor_name': 'HIV', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011809', 'descriptor_name': 'Quinones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004722', 'descriptor_name': 'Endoribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006678', 'descriptor_name': 'HIV', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006678', 'descriptor_name': 'HIV', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D011809', 'descriptor_name': 'Quinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016914', 'descriptor_name': 'Ribonuclease H', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.34.10.2009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc171980', 'pdf_url': 'https://europepmc.org/articles/pmc171980?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171980', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1705412', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc171980', 'pdf_url': 'https://europepmc.org/articles/pmc171980?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.88, 'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1508115229', 'https://openalex.org/W1519032693', 'https://openalex.org/W1524248891', 'https://openalex.org/W1569578370', 'https://openalex.org/W183585278', 'https://openalex.org/W1854515158', 'https://openalex.org/W1976439804', 'https://openalex.org/W1976816610', 'https://openalex.org/W1977241864', 'https://openalex.org/W1989791734', 'https://openalex.org/W1990291820', 'https://openalex.org/W1993078980', 'https://openalex.org/W2010284680', 'https://openalex.org/W2018893626', 'https://openalex.org/W2027861910', 'https://openalex.org/W2028735977', 'https://openalex.org/W2041419820', 'https://openalex.org/W2051073306', 'https://openalex.org/W2052306401', 'https://openalex.org/W2052794617', 'https://openalex.org/W2053934957', 'https://openalex.org/W2059454895', 'https://openalex.org/W2061566909', 'https://openalex.org/W2081347685', 'https://openalex.org/W2082760363', 'https://openalex.org/W2085459671', 'https://openalex.org/W2086186867', 'https://openalex.org/W2111139603', 'https://openalex.org/W2120165295', 'https://openalex.org/W2143788821', 'https://openalex.org/W2145404316', 'https://openalex.org/W2260050654', 'https://openalex.org/W2411462868'], 'related_works': ['https://openalex.org/W4248828958', 'https://openalex.org/W2801209660', 'https://openalex.org/W2338873733', 'https://openalex.org/W2162332760', 'https://openalex.org/W2080304317', 'https://openalex.org/W2045122766', 'https://openalex.org/W2015009754', 'https://openalex.org/W1963782006', 'https://openalex.org/W1750017366', 'https://openalex.org/W1626305077'], 'abstract_inverted_index': {'We': [0], 'studied': [1], 'the': [2, 5, 11, 25, 30, 62, 66, 75, 84, 98, 103], 'effect': [3], 'of': [4, 14, 29, 34, 58, 71, 74, 97], 'natural': [6], 'marine': [7], 'substance': [8], 'illimaquinone': [9], 'on': [10], 'catalytic': [12], 'activities': [13, 47], 'reverse': [15, 90], 'transcriptase': [16, 91], 'from': [17], 'human': [18, 85], 'immunodeficiency': [19, 86], 'virus': [20, 87], 'type': [21, 88], '1.': [22], 'Illimaquinone': [23], 'inhibited': [24], 'RNase': [26, 92], 'H': [27, 93], 'activity': [28], 'enzyme': [31], 'at': [32, 65], 'concentrations': [33], '5': [35], 'to': [36, 52, 69], '10': [37], 'microgram/ml,': [38], 'whereas': [39], 'RNA-dependent': [40], 'DNA': [41, 45], 'polymerase': [42, 46], 'and': [43], 'DNA-dependent': [44], 'were': [48], 'considerably': [49], 'less': [50], 'susceptible': [51], 'this': [53], 'inhibition.': [54], 'Two': [55], 'synthetic': [56], 'derivatives': [57], 'illimaquinone,': [59], 'in': [60, 82, 101], 'which': [61], "6'-hydroxyl": [63, 99], 'group': [64, 100], 'ortho': [67], 'position': [68], 'one': [70], 'carbonyl': [72], 'groups': [73], 'quinone': [76], 'ring': [77], 'was': [78], 'modified,': [79], 'proved': [80], 'ineffective': [81], 'inhibiting': [83], '1': [89], 'function,': [94], 'suggesting': [95], 'involvement': [96], 'blocking': [102], 'enzymatic': [104], 'activity.': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2086402826', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-17T17:56:47.864987', 'created_date': '2016-06-24'}