Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2322530366', 'doi': 'https://doi.org/10.1038/cddis.2016.72', 'title': 'Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease', 'display_name': 'Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease', 'publication_year': 2016, 'publication_date': '2016-03-31', 'ids': {'openalex': 'https://openalex.org/W2322530366', 'doi': 'https://doi.org/10.1038/cddis.2016.72', 'mag': '2322530366', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27031963', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4823968'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/cddis.2016.72', 'pdf_url': 'https://www.nature.com/articles/cddis201672.pdf', 'source': {'id': 'https://openalex.org/S185208586', 'display_name': 'Cell Death and Disease', 'issn_l': '2041-4889', 'issn': ['2041-4889'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/cddis201672.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007474952', 'display_name': 'Susann Lehmann', 'orcid': 'https://orcid.org/0000-0001-9041-3383'}, 'institutions': [{'id': 'https://openalex.org/I4210159948', 'display_name': 'MRC Toxicology Unit', 'ror': 'https://ror.org/05362x394', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210159948', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S Lehmann', 'raw_affiliation_strings': ['Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK'], 'affiliations': [{'raw_affiliation_string': 'Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK', 'institution_ids': ['https://openalex.org/I4210159948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039412970', 'display_name': 'Ana Carolina Oliveira Costa', 'orcid': 'https://orcid.org/0000-0002-5101-9604'}, 'institutions': [{'id': 'https://openalex.org/I4210159948', 'display_name': 'MRC Toxicology Unit', 'ror': 'https://ror.org/05362x394', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210159948', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A C Costa', 'raw_affiliation_strings': ['Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK'], 'affiliations': [{'raw_affiliation_string': 'Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK', 'institution_ids': ['https://openalex.org/I4210159948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088194477', 'display_name': 'Ivana Celardo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159948', 'display_name': 'MRC Toxicology Unit', 'ror': 'https://ror.org/05362x394', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210159948', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'I Celardo', 'raw_affiliation_strings': ['Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK'], 'affiliations': [{'raw_affiliation_string': 'Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK', 'institution_ids': ['https://openalex.org/I4210159948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009393013', 'display_name': 'Samantha H. Y. Loh', 'orcid': 'https://orcid.org/0000-0001-5073-6065'}, 'institutions': [{'id': 'https://openalex.org/I4210159948', 'display_name': 'MRC Toxicology Unit', 'ror': 'https://ror.org/05362x394', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210159948', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S H Y Loh', 'raw_affiliation_strings': ['Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK'], 'affiliations': [{'raw_affiliation_string': 'Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK', 'institution_ids': ['https://openalex.org/I4210159948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063408691', 'display_name': 'L. Miguel Martins', 'orcid': 'https://orcid.org/0000-0002-3019-4809'}, 'institutions': [{'id': 'https://openalex.org/I4210159948', 'display_name': 'MRC Toxicology Unit', 'ror': 'https://ror.org/05362x394', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I241749', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210159948', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'L M Martins', 'raw_affiliation_strings': ['Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK'], 'affiliations': [{'raw_affiliation_string': 'Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK', 'institution_ids': ['https://openalex.org/I4210159948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'GBP', 'value_usd': 3422, 'provenance': 'doaj'}, 'apc_paid': {'value': 2790, 'currency': 'GBP', 'value_usd': 3422, 'provenance': 'doaj'}, 'fwci': 5.348, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 55, 'citation_normalized_percentile': {'value': 0.999619, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '7', 'issue': '3', 'first_page': 'e2166', 'last_page': 'e2166'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11051', 'display_name': 'Role of Sirtuins in Health and Aging', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11051', 'display_name': 'Role of Sirtuins in Health and Aging', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dna-repair', 'display_name': 'DNA Repair', 'score': 0.523171}, {'id': 'https://openalex.org/keywords/parp-inhibitors', 'display_name': 'PARP Inhibitors', 'score': 0.517378}, {'id': 'https://openalex.org/keywords/nad+', 'display_name': 'NAD+', 'score': 0.510161}, {'id': 'https://openalex.org/keywords/nicotinic-acid-adenine-dinucleotide-phosphate', 'display_name': 'Nicotinic Acid Adenine Dinucleotide Phosphate', 'score': 0.501122}], 'concepts': [{'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.8685249}, {'id': 'https://openalex.org/C2777668072', 'wikidata': 'https://www.wikidata.org/wiki/Q2472777', 'display_name': 'Parkin', 'level': 4, 'score': 0.74458975}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.66291493}, {'id': 'https://openalex.org/C182979987', 'wikidata': 'https://www.wikidata.org/wiki/Q3907241', 'display_name': 'Poly ADP ribose polymerase', 'level': 4, 'score': 0.5468107}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.5360359}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.48809302}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43547034}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36133552}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.3535239}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.34960234}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.14572248}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.117008716}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.11329639}], 'mesh': [{'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011065', 'descriptor_name': 'Poly(ADP-ribose) Polymerases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019587', 'descriptor_name': 'Dietary Supplements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059290', 'descriptor_name': 'Dopaminergic Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059290', 'descriptor_name': 'Dopaminergic Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004330', 'descriptor_name': 'Drosophila', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016296', 'descriptor_name': 'Mutagenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009243', 'descriptor_name': 'NAD', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009243', 'descriptor_name': 'NAD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011065', 'descriptor_name': 'Poly(ADP-ribose) Polymerases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011065', 'descriptor_name': 'Poly(ADP-ribose) Polymerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/cddis.2016.72', 'pdf_url': 'https://www.nature.com/articles/cddis201672.pdf', 'source': {'id': 'https://openalex.org/S185208586', 'display_name': 'Cell Death and Disease', 'issn_l': '2041-4889', 'issn': ['2041-4889'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4823968', 'pdf_url': 'https://europepmc.org/articles/pmc4823968?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Parp_mutations_protect_against_mitochondrial_dysfunction_and_neurodegeneration_in_a_PARKIN_model_of_Parkinson_s_disease/10179206', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Parp_mutations_protect_against_mitochondrial_dysfunction_and_neurodegeneration_in_a_PARKIN_model_of_Parkinson_s_disease/10179206/1/files/18345026.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois at Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois at Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2381/37658', 'pdf_url': 'https://figshare.le.ac.uk/articles/journal_contribution/Parp_mutations_protect_against_mitochondrial_dysfunction_and_neurodegeneration_in_a_PARKIN_model_of_Parkinson_s_disease/10179206/1/files/18345026.pdf', 'source': {'id': 'https://openalex.org/S4306402365', 'display_name': 'Leicester Research Archive (University of Leicester)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I153648349', 'host_organization_name': 'University of Leicester', 'host_organization_lineage': ['https://openalex.org/I153648349'], 'host_organization_lineage_names': ['University of Leicester'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823968', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27031963', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/cddis.2016.72', 'pdf_url': 'https://www.nature.com/articles/cddis201672.pdf', 'source': {'id': 'https://openalex.org/S185208586', 'display_name': 'Cell Death and Disease', 'issn_l': '2041-4889', 'issn': ['2041-4889'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/7', 'score': 0.44, 'display_name': 'Affordable and clean energy'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1603237166', 'https://openalex.org/W1959721425', 'https://openalex.org/W1964895626', 'https://openalex.org/W1977841860', 'https://openalex.org/W1983607918', 'https://openalex.org/W1989362964', 'https://openalex.org/W1995557989', 'https://openalex.org/W2001531966', 'https://openalex.org/W2009834187', 'https://openalex.org/W2010298858', 'https://openalex.org/W2012043504', 'https://openalex.org/W2020304127', 'https://openalex.org/W2024610036', 'https://openalex.org/W2028178274', 'https://openalex.org/W2031340015', 'https://openalex.org/W2032730372', 'https://openalex.org/W2037316279', 'https://openalex.org/W2037654673', 'https://openalex.org/W2042264135', 'https://openalex.org/W2043299439', 'https://openalex.org/W2050849483', 'https://openalex.org/W2051439699', 'https://openalex.org/W2055124287', 'https://openalex.org/W2055734355', 'https://openalex.org/W2074161856', 'https://openalex.org/W2080915753', 'https://openalex.org/W2082393205', 'https://openalex.org/W2082797287', 'https://openalex.org/W2084060660', 'https://openalex.org/W2089838011', 'https://openalex.org/W2104457046', 'https://openalex.org/W2113321399', 'https://openalex.org/W2114382609', 'https://openalex.org/W2128016549', 'https://openalex.org/W2128974910', 'https://openalex.org/W2133725395', 'https://openalex.org/W2141796595', 'https://openalex.org/W2160627990', 'https://openalex.org/W2167665292', 'https://openalex.org/W2200289518'], 'related_works': ['https://openalex.org/W4281750502', 'https://openalex.org/W4211142735', 'https://openalex.org/W3129077222', 'https://openalex.org/W3019462745', 'https://openalex.org/W2199170222', 'https://openalex.org/W2155015733', 'https://openalex.org/W2108326484', 'https://openalex.org/W2005802923', 'https://openalex.org/W1991231925', 'https://openalex.org/W1518060892'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'co-enzyme': [2], 'nicotinamide': [3, 77], 'adenine': [4], 'dinucleotide': [5], '(NAD': [6], '+': [7, 32, 59, 75, 99, 120, 132, 144], ')': [8], 'is': [9, 40, 82], 'an': [10], 'essential': [11], 'co-factor': [12], 'for': [13, 22, 142], 'cellular': [14], 'energy': [15], 'generation': [16], 'in': [17, 26, 42, 57, 62, 88], 'mitochondria': [18, 141], 'as': [19, 21, 136], 'well': [20], 'DNA': [23], 'repair': [24], 'mechanisms': [25], 'the': [27, 73, 128], 'cell': [28], 'nucleus': [29], 'involving': [30], 'NAD': [31, 58, 74, 98, 119, 131, 143], '-consuming': [33], 'poly': [34], '(ADP-ribose)': [35], 'polymerases': [36], '(PARPs).': [37], 'Mitochondrial': [38], 'function': [39, 80, 108], 'compromised': [41], 'animal': [43], 'models': [44], 'of': [45, 97, 124, 130], 'Parkinson’s': [46], 'disease': [47], '(PD)': [48], 'associated': [49, 152], 'with': [50, 72, 140, 153], 'PARKIN': [51], 'mutations.': [52], 'Here,': [53], 'we': [54, 91], 'uncovered': [55], 'alterations': [56], 'salvage': [60, 102], 'metabolism': [61], 'Drosophila': [63], 'parkin': [64, 89], 'mutants.': [65], 'We': [66, 113], 'show': [67, 92], 'that': [68, 93, 115, 138], 'a': [69], 'dietary': [70, 125], 'supplementation': [71], 'precursor': [76], 'rescues': [78, 106], 'mitochondrial': [79, 107, 154], 'and': [81, 100, 109], 'neuroprotective.': [83], 'Further,': [84], 'by': [85, 122], 'mutating': [86], 'Parp': [87], 'mutants,': [90], 'this': [94], 'increases': [95], 'levels': [96, 121], 'its': [101], 'metabolites.': [103], 'This': [104], 'also': [105], 'suppresses': [110], 'dopaminergic': [111], 'neurodegeneration.': [112], 'conclude': [114], 'strategies': [116], 'to': [117, 148], 'enhance': [118], 'administration': [123], 'precursors': [126], 'or': [127], 'inhibition': [129], '-dependent': [133], 'enzymes,': [134], 'such': [135], 'PARP,': [137], 'compete': [139], 'could': [145], 'be': [146], 'used': [147], 'delay': [149], 'neuronal': [150], 'death': [151], 'dysfunction.': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2322530366', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-14T12:03:51.928072', 'created_date': '2016-06-24'}