Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2155015733', 'doi': 'https://doi.org/10.1083/jcb.200809125', 'title': 'Parkin is recruited selectively to impaired mitochondria and promotes their autophagy', 'display_name': 'Parkin is recruited selectively to impaired mitochondria and promotes their autophagy', 'publication_year': 2008, 'publication_date': '2008-11-24', 'ids': {'openalex': 'https://openalex.org/W2155015733', 'doi': 'https://doi.org/10.1083/jcb.200809125', 'mag': '2155015733', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19029340', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2592826'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200809125', 'pdf_url': 'https://rupress.org/jcb/article-pdf/183/5/795/1567991/jcb_200809125.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://rupress.org/jcb/article-pdf/183/5/795/1567991/jcb_200809125.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007297638', 'display_name': 'Derek P. Narendra', 'orcid': 'https://orcid.org/0000-0002-8696-9108'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210110767', 'display_name': 'National Institute of Neurological Disorders and Stroke', 'ror': 'https://ror.org/01s5ya894', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Derek Narendra', 'raw_affiliation_strings': ['1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892', '2Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814'], 'affiliations': [{'raw_affiliation_string': '2Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I1344073410']}, {'raw_affiliation_string': '1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892', 'institution_ids': ['https://openalex.org/I4210110767', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101605689', 'display_name': 'Atsushi Tanaka', 'orcid': 'https://orcid.org/0000-0002-7566-2098'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210110767', 'display_name': 'National Institute of Neurological Disorders and Stroke', 'ror': 'https://ror.org/01s5ya894', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Tanaka', 'raw_affiliation_strings': ['1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030406676', 'display_name': 'Der‐Fen Suen', 'orcid': 'https://orcid.org/0000-0002-4868-8284'}, 'institutions': [{'id': 'https://openalex.org/I4210110767', 'display_name': 'National Institute of Neurological Disorders and Stroke', 'ror': 'https://ror.org/01s5ya894', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Der-Fen Suen', 'raw_affiliation_strings': ['1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892', 'institution_ids': ['https://openalex.org/I4210110767', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016723424', 'display_name': 'Richard J. Youle', 'orcid': 'https://orcid.org/0000-0001-9117-5241'}, 'institutions': [{'id': 'https://openalex.org/I4210110767', 'display_name': 'National Institute of Neurological Disorders and Stroke', 'ror': 'https://ror.org/01s5ya894', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard J. Youle', 'raw_affiliation_strings': ['1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892', 'institution_ids': ['https://openalex.org/I4210110767', 'https://openalex.org/I1299303238']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 98.005, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3537, 'citation_normalized_percentile': {'value': 0.999962, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '183', 'issue': '5', 'first_page': '795', 'last_page': '803'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9681, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/autophagy', 'display_name': 'Autophagy', 'score': 0.507611}, {'id': 'https://openalex.org/keywords/pink1', 'display_name': 'PINK1', 'score': 0.4223115}], 'concepts': [{'id': 'https://openalex.org/C2777668072', 'wikidata': 'https://www.wikidata.org/wiki/Q2472777', 'display_name': 'Parkin', 'level': 4, 'score': 0.98723507}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.8624697}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.84298414}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.7534417}, {'id': 'https://openalex.org/C2779324830', 'wikidata': 'https://www.wikidata.org/wiki/Q1806192', 'display_name': 'Mitophagy', 'level': 4, 'score': 0.74144757}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.67318577}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.6129906}, {'id': 'https://openalex.org/C2780104201', 'wikidata': 'https://www.wikidata.org/wiki/Q130888', 'display_name': 'Drosophila melanogaster', 'level': 3, 'score': 0.53974164}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.4789696}, {'id': 'https://openalex.org/C2776804853', 'wikidata': 'https://www.wikidata.org/wiki/Q18045837', 'display_name': 'PINK1', 'level': 5, 'score': 0.4223115}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.33522356}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27211165}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.18505055}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15624455}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.08379811}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.05571872}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.05425051}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014475', 'descriptor_name': 'Uncoupling Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014475', 'descriptor_name': 'Uncoupling Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200809125', 'pdf_url': 'https://rupress.org/jcb/article-pdf/183/5/795/1567991/jcb_200809125.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2592826', 'pdf_url': 'https://europepmc.org/articles/pmc2592826?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592826', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19029340', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200809125', 'pdf_url': 'https://rupress.org/jcb/article-pdf/183/5/795/1567991/jcb_200809125.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1877873625', 'https://openalex.org/W1968843321', 'https://openalex.org/W1976645698', 'https://openalex.org/W1985119207', 'https://openalex.org/W1993772997', 'https://openalex.org/W2001531966', 'https://openalex.org/W2022827866', 'https://openalex.org/W2031172417', 'https://openalex.org/W2047242847', 'https://openalex.org/W2050849483', 'https://openalex.org/W2055124287', 'https://openalex.org/W2058653820', 'https://openalex.org/W2065665245', 'https://openalex.org/W2069403245', 'https://openalex.org/W2075088486', 'https://openalex.org/W2090945233', 'https://openalex.org/W2093650005', 'https://openalex.org/W2098095284', 'https://openalex.org/W2105601225', 'https://openalex.org/W2111682630', 'https://openalex.org/W2113507118', 'https://openalex.org/W2124140045', 'https://openalex.org/W2128537698', 'https://openalex.org/W2129248872', 'https://openalex.org/W2129826948', 'https://openalex.org/W2131007152', 'https://openalex.org/W2139636031', 'https://openalex.org/W2143161560', 'https://openalex.org/W2144687501', 'https://openalex.org/W2154938348', 'https://openalex.org/W2155643523', 'https://openalex.org/W2164174765'], 'related_works': ['https://openalex.org/W4303633859', 'https://openalex.org/W4281611459', 'https://openalex.org/W4212846144', 'https://openalex.org/W2805130622', 'https://openalex.org/W2599575818', 'https://openalex.org/W2598349524', 'https://openalex.org/W2593974461', 'https://openalex.org/W2550066450', 'https://openalex.org/W2415916782', 'https://openalex.org/W1146046970'], 'abstract_inverted_index': {'Loss-of-function': [0], 'mutations': [1], 'in': [2, 26, 51, 65, 83, 121], 'Park2,': [3], 'the': [4, 8, 22, 37, 90, 97, 122], 'gene': [5], 'coding': [6], 'for': [7], 'ubiquitin': [9], 'ligase': [10], 'Parkin,': [11], 'are': [12], 'a': [13, 115], 'significant': [14], 'cause': [15], 'of': [16, 24, 39, 92, 100, 110, 124], 'early': [17], 'onset': [18], "Parkinson's": [19, 125], 'disease.': [20, 126], 'Although': [21], 'role': [23], 'Parkin': [25, 35, 72, 88, 107], 'neuron': [27], 'maintenance': [28], 'is': [29, 43, 73], 'unknown,': [30], 'recent': [31], 'work': [32], 'has': [33], 'linked': [34], 'to': [36, 62, 76, 117], 'regulation': [38], 'mitochondria.': [40, 102], 'Its': [41], 'loss': [42], 'associated': [44], 'with': [45, 79], 'swollen': [46], 'mitochondria': [47, 78, 93, 112, 120], 'and': [48, 59, 96, 113], 'muscle': [49], 'degeneration': [50], 'Drosophila': [52], 'melanogaster,': [53], 'as': [54, 56], 'well': [55], 'mitochondrial': [57, 63], 'dysfunction': [58], 'increased': [60], 'susceptibility': [61], 'toxins': [64], 'other': [66], 'species.': [67], 'Here,': [68], 'we': [69], 'show': [70, 105], 'that': [71, 106], 'selectively': [74], 'recruited': [75], 'dysfunctional': [77, 119], 'low': [80], 'membrane': [81], 'potential': [82], 'mammalian': [84], 'cells.': [85], 'After': [86], 'recruitment,': [87], 'mediates': [89], 'engulfment': [91], 'by': [94], 'autophagosomes': [95], 'selective': [98], 'elimination': [99], 'impaired': [101], 'These': [103], 'results': [104], 'promotes': [108], 'autophagy': [109], 'damaged': [111], 'implicate': [114], 'failure': [116], 'eliminate': [118], 'pathogenesis': [123]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2155015733', 'counts_by_year': [{'year': 2024, 'cited_by_count': 150}, {'year': 2023, 'cited_by_count': 222}, {'year': 2022, 'cited_by_count': 269}, {'year': 2021, 'cited_by_count': 263}, {'year': 2020, 'cited_by_count': 281}, {'year': 2019, 'cited_by_count': 238}, {'year': 2018, 'cited_by_count': 239}, {'year': 2017, 'cited_by_count': 239}, {'year': 2016, 'cited_by_count': 230}, {'year': 2015, 'cited_by_count': 235}, {'year': 2014, 'cited_by_count': 259}, {'year': 2013, 'cited_by_count': 249}, {'year': 2012, 'cited_by_count': 225}], 'updated_date': '2024-09-13T08:37:59.646553', 'created_date': '2016-06-24'}