Publication Information

{'id': 'https://openalex.org/W2319633773', 'doi': 'https://doi.org/10.1016/j.juro.2014.02.289', 'title': 'MP24-08 INHIBITION OF CONSTITUTIVELY ACTIVE STAT3 REVERSES ENZALUTAMIDE RESISTANCE IN LNCAP DERIVATIVE PROSTATE CANCER CELLS', 'display_name': 'MP24-08 INHIBITION OF CONSTITUTIVELY ACTIVE STAT3 REVERSES ENZALUTAMIDE RESISTANCE IN LNCAP DERIVATIVE PROSTATE CANCER CELLS', 'publication_year': 2014, 'publication_date': '2014-03-28', 'ids': {'openalex': 'https://openalex.org/W2319633773', 'doi': 'https://doi.org/10.1016/j.juro.2014.02.289', 'mag': '2319633773'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2014.02.289', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101592945', 'display_name': 'Chengfei Liu', 'orcid': 'https://orcid.org/0000-0002-2452-8788'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chengfei Liu', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109567068', 'display_name': 'Yezi Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yezi Zhu', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012734277', 'display_name': 'Wei Lou', 'orcid': 'https://orcid.org/0000-0002-4688-1216'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Lou', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101764594', 'display_name': 'Yuanyuan Cui', 'orcid': 'https://orcid.org/0000-0003-3782-1315'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuanyuan Cui', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088621070', 'display_name': 'Christopher P. Evans', 'orcid': 'https://orcid.org/0000-0001-5626-8901'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher P. Evans', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048369552', 'display_name': 'Allen C. Gao', 'orcid': 'https://orcid.org/0000-0002-5966-9038'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen C. Gao', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '191', 'issue': '4S', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.9467863}, {'id': 'https://openalex.org/keywords/survivin', 'display_name': 'Survivin', 'score': 0.686898}, {'id': 'https://openalex.org/keywords/du145', 'display_name': 'DU145', 'score': 0.5100056}, {'id': 'https://openalex.org/keywords/clonogenic-assay', 'display_name': 'Clonogenic assay', 'score': 0.47999308}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.9467863}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.84205437}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7898807}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7202816}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.7075417}, {'id': 'https://openalex.org/C2775975398', 'wikidata': 'https://www.wikidata.org/wiki/Q906904', 'display_name': 'Survivin', 'level': 3, 'score': 0.686898}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.66059333}, {'id': 'https://openalex.org/C2776438761', 'wikidata': 'https://www.wikidata.org/wiki/Q5206280', 'display_name': 'DU145', 'level': 5, 'score': 0.5100056}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.48298872}, {'id': 'https://openalex.org/C117262875', 'wikidata': 'https://www.wikidata.org/wiki/Q5135057', 'display_name': 'Clonogenic assay', 'level': 3, 'score': 0.47999308}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.47974813}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.4762145}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.2967233}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29001182}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19881856}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.13931537}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.1109595}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.079874724}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2014.02.289', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.64, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1779691448', 'https://openalex.org/W1968365367', 'https://openalex.org/W1968855063', 'https://openalex.org/W1973612890', 'https://openalex.org/W1981467511', 'https://openalex.org/W1985619138', 'https://openalex.org/W1995039837', 'https://openalex.org/W2005811367', 'https://openalex.org/W2006382528', 'https://openalex.org/W2009017218', 'https://openalex.org/W2014556566', 'https://openalex.org/W2017715430', 'https://openalex.org/W2018446432', 'https://openalex.org/W2023243995', 'https://openalex.org/W2067841857', 'https://openalex.org/W2088357471', 'https://openalex.org/W2119504728', 'https://openalex.org/W2127342790', 'https://openalex.org/W2133059565', 'https://openalex.org/W2143693972', 'https://openalex.org/W2144713347', 'https://openalex.org/W2145777186', 'https://openalex.org/W2148643283', 'https://openalex.org/W2150627722', 'https://openalex.org/W2152197423', 'https://openalex.org/W2156865225', 'https://openalex.org/W2170647183', 'https://openalex.org/W2783142245'], 'related_works': ['https://openalex.org/W92953675', 'https://openalex.org/W2954788551', 'https://openalex.org/W294322201', 'https://openalex.org/W2506336108', 'https://openalex.org/W2376303753', 'https://openalex.org/W2365043862', 'https://openalex.org/W2171401288', 'https://openalex.org/W2079866018', 'https://openalex.org/W1998341483', 'https://openalex.org/W1973861095'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 113, 119, 140, 145, 157, 185, 192, 208, 232, 240, 248, 255, 275, 333, 345], 'UrologyProstate': [4], 'Cancer:': [5], 'Basic': [6], 'Research': [7], 'I1': [8], 'Apr': [9], '2014MP24-08': [10], 'INHIBITION': [11], 'OF': [12], 'CONSTITUTIVELY': [13], 'ACTIVE': [14], 'STAT3': [15], 'REVERSES': [16], 'ENZALUTAMIDE': [17], 'RESISTANCE': [18], 'IN': [19], 'LNCAP': [20], 'DERIVATIVE': [21], 'PROSTATE': [22], 'CANCER': [23], 'CELLS': [24], 'Chengfei': [25, 40, 362], 'Liu,': [26], 'Yezi': [27, 49, 369], 'Zhu,': [28], 'Wei': [29, 58, 376], 'Lou,': [30], 'Yuanyuan': [31, 67, 383], 'Cui,': [32], 'Christopher': [33, 76, 390], 'P.': [34, 77, 79, 391], 'Evans,': [35], 'and': [36, 87, 142, 169, 176, 189, 225, 234, 303, 309], 'Allen': [37, 88, 398], 'C.': [38, 89, 91, 399], 'Gao': [39, 92, 400], 'LiuChengfei': [41], 'Liu': [42, 363], 'More': [43, 52, 61, 70, 81, 93, 364, 371, 378, 385, 393, 401], 'articles': [44, 53, 62, 71, 82, 94, 365, 372, 379, 386, 394, 402], 'by': [45, 54, 63, 72, 83, 95, 285, 366, 373, 380, 387, 395, 403], 'this': [46, 55, 64, 73, 84, 96, 367, 374, 381, 388, 396, 404], 'author': [47, 56, 65, 74, 85, 97, 368, 375, 382, 389, 397, 405], ',': [48, 57, 66, 75, 86], 'ZhuYezi': [50], 'Zhu': [51, 370], 'LouWei': [59], 'Lou': [60, 377], 'CuiYuanyuan': [68], 'Cui': [69, 384], 'EvansChristopher': [78], 'Evans': [80, 392], 'GaoAllen': [90], 'View': [98], 'All': [99, 407], 'Author': [100], 'Informationhttps://doi.org/10.1016/j.juro.2014.02.289AboutPDF': [101], 'ToolsAdd': [102], 'to': [103, 125, 136, 153, 161, 181, 199, 205, 210, 223, 229, 243, 252, 265, 277], 'favoritesDownload': [104], 'CitationsTrack': [105], 'CitationsPermissionsReprints': [106], 'ShareFacebookTwitterLinked': [107], 'InEmail': [108], 'INTRODUCTION': [109], 'AND': [110], 'OBJECTIVES': [111], 'Use': [112], 'enzalutamide': [114, 126, 162, 224, 266, 292, 302, 323, 339], 'has': [115], 'improved': [116], 'the': [117, 211, 273, 318, 330], 'treatment': [118, 300, 344], 'advanced': [120, 346], 'prostate': [121, 148, 158, 249, 260, 295, 326, 347], 'cancer.': [122, 348], 'However,': [123], 'resistance': [124, 152, 264, 293, 324], 'can': [127], 'develop': [128], 'frequently': [129], 'in': [130, 147, 246, 259, 294, 325], 'initial': [131], 'responders.': [132], 'This': [133, 314], 'study': [134, 315], 'aimed': [135], 'test': [137], 'whether': [138], 'overexpression': [139], 'IL-6': [141, 220, 227, 320], 'constitutive': [143, 230, 331], 'activation': [144, 231, 332], 'Stat3': [146, 193, 233, 241, 258, 270, 288], 'cancer': [149, 159, 216, 250, 261, 296, 327], 'cells': [150, 160, 217, 251, 262, 328], 'increase': [151, 245], 'enzalutamide.': [154, 253, 286], 'METHODS': [155], 'Sensitivity': [156], 'was': [163, 194, 203], 'tested': [164], 'using': [165, 196], 'cell': [166, 307, 311], 'growth': [167, 308], 'assays': [168], 'clonogenic': [170], 'assays.': [171], 'Quantitative': [172], 'reverse': [173], 'transcription-PCR,': [174], 'ELISA': [175], 'Western': [177], 'blotting': [178], 'were': [179], 'performed': [180, 204], 'detect': [182], 'expression': [183], 'levels': [184], 'IL-6,': [186], 'c-Myc,': [187], 'survivin': [188], 'AR.': [190], 'Expression': [191], 'downregulated': [195], 'siRNA': [197], 'specific': [198], 'Stat3.': [200, 334], 'ChIP': [201], 'assay': [202], 'examine': [206], 'recruitment': [207, 274], 'AR': [209, 276], 'PSA': [212, 278], 'promoter.': [213], 'RESULTS': [214], 'Prostate': [215], 'expressing': [218], 'autocrine': [219, 226, 319], 'are': [221], 'resistant': [222], 'leads': [228], 'its': [235], 'target': [236], 'genes.': [237], 'Down': [238], 'regulation': [239], 'led': [242], 'an': [244], 'sensitivity': [247], 'Overexpression': [254], 'constitutively': [256], 'active': [257, 269], 'induced': [263, 310], 'treatment.': [267], 'Constitutively': [268], 'also': [271], 'enhanced': [272], 'promoter': [279], 'which': [280], 'could': [281], 'not': [282], 'be': [283, 341], 'disrupted': [284], 'The': [287], 'inhibitor': [289], 'AG490': [290, 304], 'reversed': [291], 'cells,': [297], 'while': [298], 'combination': [299], 'with': [301, 338], 'significantly': [305], 'inhibited': [306], 'apoptosis.': [312], 'CONCLUSIONS': [313], 'demonstrates': [316], 'that': [317], 'pathway': [321, 337], 'induces': [322], 'via': [329], 'Co-targeting': [335], 'IL6-Stat3': [336], 'may': [340], 'utilized': [342], 'for': [343], '©': [349], '2014FiguresReferencesRelatedDetails': [350], 'Volume': [351], '191Issue': [352], '4SApril': [353], '2014Page:': [354], 'e262': [355], 'Advertisement': [356, 408, 409], 'Copyright': [357], '&': [358], 'Permissions©': [359], '2014MetricsAuthor': [360], 'Information': [361], 'Expand': [406], 'PDF': [410], 'downloadLoading': [411], '...': [412]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2319633773', 'counts_by_year': [], 'updated_date': '2024-12-08T23:13:15.957732', 'created_date': '2016-06-24'}