Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2506336108', 'doi': 'https://doi.org/10.1158/1538-7445.am2016-1581', 'title': 'Abstract 1581: Crosstalk of androgen sensitive prostate cancer cells and insensitive prostate cancer cells', 'display_name': 'Abstract 1581: Crosstalk of androgen sensitive prostate cancer cells and insensitive prostate cancer cells', 'publication_year': 2016, 'publication_date': '2016-07-15', 'ids': {'openalex': 'https://openalex.org/W2506336108', 'doi': 'https://doi.org/10.1158/1538-7445.am2016-1581', 'mag': '2506336108'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2016-1581', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057812946', 'display_name': 'Yuta Takezawa', 'orcid': 'https://orcid.org/0000-0001-8260-0701'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuta Takezawa', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036460015', 'display_name': 'Atsushi Mizokami', 'orcid': 'https://orcid.org/0000-0002-5643-2182'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Mizokami', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015065037', 'display_name': 'Kazuaki Machioka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuaki Machioka', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056369807', 'display_name': 'Kouji Izumi', 'orcid': 'https://orcid.org/0000-0002-8480-9100'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kouji Izumi', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009445050', 'display_name': 'Hiroaki Iwamoto', 'orcid': 'https://orcid.org/0000-0003-3599-2217'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Iwamoto', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055943682', 'display_name': 'Aerken Maolake', 'orcid': 'https://orcid.org/0000-0003-2880-0862'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Maolake Aerken', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073143507', 'display_name': 'Natsagdorg Ariunbold', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Natsagdorg Ariunbold', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108468568', 'display_name': 'Mikio Namiki', 'orcid': 'https://orcid.org/0000-0002-0415-650X'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mikio Namiki', 'raw_affiliation_strings': ['Kanazawa University, Ishikawa, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kanazawa University, Ishikawa, Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '76', 'issue': '14_Supplement', 'first_page': '1581', 'last_page': '1581'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9732, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9732, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/du145', 'display_name': 'DU145', 'score': 0.9947592}, {'id': 'https://openalex.org/keywords/dihydrotestosterone', 'display_name': 'Dihydrotestosterone', 'score': 0.49662524}], 'concepts': [{'id': 'https://openalex.org/C2776438761', 'wikidata': 'https://www.wikidata.org/wiki/Q5206280', 'display_name': 'DU145', 'level': 5, 'score': 0.9947592}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.98132217}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7995267}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5947859}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.58483857}, {'id': 'https://openalex.org/C2779881493', 'wikidata': 'https://www.wikidata.org/wiki/Q411054', 'display_name': 'Dihydrotestosterone', 'level': 4, 'score': 0.49662524}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4203254}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.41073576}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3876548}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.37537816}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35963118}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3562122}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.08731201}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2016-1581', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.64, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W92953675', 'https://openalex.org/W2954788551', 'https://openalex.org/W294322201', 'https://openalex.org/W2506336108', 'https://openalex.org/W2365043862', 'https://openalex.org/W2343596771', 'https://openalex.org/W2171401288', 'https://openalex.org/W2030067263', 'https://openalex.org/W1998341483', 'https://openalex.org/W1973861095'], 'abstract_inverted_index': {'Abstract': [0], '[Background]': [1], 'The': [2], 'mechanisms': [3], 'that': [4, 20], 'prostate': [5, 224, 229], 'cancer': [6, 225, 230], '(PCa)': [7], 'progresses': [8], 'to': [9, 59], 'castration-resistant': [10], 'PCa': [11, 21, 28, 191, 195], '(CRPC)': [12], 'are': [13], 'adaptation': [14], 'and': [15, 31, 62, 76, 97, 104, 123, 137, 165, 177, 193, 227], 'clonal': [16], 'selection.': [17], 'We': [18, 115], 'hypothesized': [19], 'proliferated': [22], 'while': [23], 'each': [24], 'mechanism': [25], 'cooperated': [26], 'when': [27], 'recurred.': [29], '[Materials': [30], 'Methods]': [32], 'After': [33], 'LNCaP': [34, 45, 86, 100, 110, 160, 171, 179], 'cells': [35, 111, 125, 192, 196, 226], 'were': [36, 46, 57, 87, 101, 106, 126], 'transfected': [37], 'with': [38, 48, 89, 109], 'luciferase': [39, 63], 'reporter': [40], 'driven': [41], 'by': [42, 81, 119, 163], 'PSA': [43, 139, 155], 'promoter,': [44], 'cocultured': [47, 88, 108], 'androgen-insensitive': [49, 194], 'DU145': [50, 90, 103, 136, 152, 158, 176], 'or': [51, 55, 71, 91], 'PC-3.': [52, 150, 178], 'Then': [53], 'DHEA': [54, 70, 130], 'DHT': [56, 72, 134, 164], 'added': [58, 69], 'the': [60, 74, 144, 236, 241], 'medium': [61, 75], 'assay': [64], 'was': [65, 131, 146], 'performed.': [66], 'Also,': [67], 'we': [68], 'in': [73, 94, 135, 142, 149], 'measured': [77], 'various': [78], 'androgens': [79], 'level': [80], 'LC-MS/MS.': [82], 'As': [83], 'for': [84, 112, 244], 'proliferation,': [85], 'PC': [92], '-3': [93], '2-layer': [95, 121], 'chamber': [96, 122], 'number': [98], 'of': [99, 175, 182, 200, 221, 235, 240], 'counted.': [102, 127], 'PC-3': [105, 168], 'also': [107, 116, 172], '4': [113], 'days.': [114], 'checked': [117], 'migration': [118, 181], 'using': [120], 'migrated': [124], '[Results]': [128], 'Whereas': [129], 'converted': [132], 'into': [133], 'induced': [138], 'promoter': [140, 156], 'activity': [141], 'LNCaP,': [143], 'effect': [145], 'not': [147, 185], 'found': [148], 'Moreover,': [151], 'elevated': [153], 'DHT-induced': [154], 'activity.': [157], 'promoted': [159, 173, 180], 'proliferation': [161, 174], 'stimulated': [162], 'DHEA,': [166], 'but': [167, 184], 'did': [169], 'not.': [170], 'PC-3,': [183], 'DU145.': [186], '[Conclusion]': [187], 'Cross-talk': [188], 'between': [189], 'androgen-sensitive': [190], 'might': [197], 'regulate': [198], 'progression': [199], 'CRPC.': [201], 'Citation': [202], 'Format:': [203], 'Yuta': [204], 'Takezawa,': [205], 'Atsushi': [206], 'Mizokami,': [207], 'Kazuaki': [208], 'Machioka,': [209], 'Kouji': [210], 'Izumi,': [211], 'Hiroaki': [212], 'Iwamoto,': [213], 'Maolake': [214], 'Aerken,': [215], 'Natsagdorg': [216], 'Ariunbold,': [217], 'Mikio': [218], 'Namiki.': [219], 'Crosstalk': [220], 'androgen': [222], 'sensitive': [223], 'insensitive': [228], 'cells.': [231], '[abstract].': [232], 'In:': [233], 'Proceedings': [234], '107th': [237], 'Annual': [238], 'Meeting': [239], 'American': [242], 'Association': [243], 'Cancer': [245, 256], 'Research;': [246], '2016': [247], 'Apr': [248], '16-20;': [249], 'New': [250], 'Orleans,': [251], 'LA.': [252], 'Philadelphia': [253], '(PA):': [254], 'AACR;': [255], 'Res': [257], '2016;76(14': [258], 'Suppl):Abstract': [259], 'nr': [260], '1581.': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2506336108', 'counts_by_year': [], 'updated_date': '2024-12-12T23:21:35.369941', 'created_date': '2016-08-23'}