Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation

Name: Work Video:
Duration: 3 min 30 s
Abigail S. Haka; Valéria C. Barbosa-Lorenzi; Hyuek Jong Lee; Domenick J. Falcone; Clifford A. Hudis; Andrew J. Dannenberg; Frederick R. Maxfield
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185, 217, 242, 253, 281, 289, 368, 374, 379, 396, 417, 437, 446, 481, 518, 528, 625, 636, 638, 708, 773, 781, 923, 964, 1009, 1049, 1165, 1176, 1202, 1230, 1455, 1636, 1659, 1669, 1709, 1716, 1726, 1751, 1768, 1773, 1802, 1813, 1866, 1872, 1902, 1957, 2002, 2064, 2076, 2221, 2227, 2261, 2282, 2341, 2385, 2408, 2417, 2427, 2548, 2557, 2611, 2684, 2720, 2855, 2938, 2945, 3046, 3081, 3192, 3259, 3298, 3417, 3437, 3477, 3644, 3666, 3681, 3696, 3739, 3785, 3831, 3893, 3914, 3927, 3969, 4092, 4146, 4198, 4225, 4267, 4365], 'digested': [8, 27, 186, 205, 1029, 1904], 'by': [9, 28, 108, 120, 138, 176, 187, 206, 286, 298, 316, 354, 628, 1030, 1356, 1484, 2098, 2138, 2190, 2307, 2333, 2686, 2732, 2742, 2793, 2803, 2912, 2980, 3003, 3316, 3886, 4119, 4193, 4215], 'macrophages.': [10, 177, 188, 355, 2787], 'Adipocytes': [11, 189, 2376], 'can': [12, 190, 930], 'be': [13, 26, 174, 191, 204, 352, 1442, 4373], 'hundreds': [14, 192], 'times': [16, 194], 'larger': [17, 195], 'than': [18, 196, 991, 1993, 3524], 'macrophages,': [19, 197], 'so': [20, 198, 1983], 'they': [21, 199], 'too': [23, 171, 201, 349], 'large': [24, 142, 172, 202, 320, 350, 1017, 1488], 'to': [25, 124, 173, 203, 302, 351, 1023, 1140, 1332, 1360, 1534, 1630, 1652, 1690, 1746, 1928, 1959, 1989, 2161, 2253, 2364, 2679, 2696, 2707, 2711, 2745, 2769, 2778, 2782, 2806, 2841, 2929, 2977, 3238, 3245, 3352, 3419, 3422, 3730, 3837, 3975, 4088, 4126, 4136, 4345, 4372], 'conventional': [29, 207], 'phagocytic': [30, 208], 'processes.': [31, 209], 'The': [32, 210, 1706, 2527, 2701, 2723, 2788, 3307, 3466, 3487, 3550, 3562, 3765, 3828, 3900, 3979, 4064, 4188], 'nature': [33, 211], 'the': [35, 150, 154, 213, 328, 332, 520, 547, 581, 809, 816, 820, 823, 910, 928, 996, 1005, 1024, 1060, 1185, 1205, 1235, 1260, 1357, 1376, 1431, 1461, 1495, 1499, 1506, 1516, 1554, 1619, 1628, 1634, 1920, 1932, 1990, 2088, 2254, 2310, 2510, 2587, 2675, 2693, 2708, 2733, 2765, 2779, 2794, 2923, 2932, 2936, 2961, 2983, 2989, 3022, 3071, 3109, 3219, 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284, 1612], 'delivered': [107, 285, 1613], 'exocytosis.': [109, 287, 1615], 'Uptake': [110, 288, 1056], 'complete': [112, 290], 'degradation': [113, 162, 291, 340, 1264, 1446], 'adipocyte': [115, 293, 1621, 1635, 2136, 2937, 3495, 3987, 4100], 'fragments,': [116, 294, 1931], 'which': [117, 139, 146, 295, 317, 324, 800, 1016, 1485, 1492], 'released': [119, 297, 994], 'hydrolysis,': [122, 300], 'leads': [123, 301], 'foam': [126, 130, 304, 308, 516, 840, 891, 1361, 1365, 1380, 1412, 1465, 1476, 1641, 1647, 4035], 'formation.': [128, 306, 1363], 'Exophagy-mediated': [129, 307, 1475], 'formation': [132, 310, 1367, 1382, 1467, 1478, 1649, 4037], 'highly': [135, 313, 1481], 'efficient': [136, 314, 1482], 'means': [137, 315, 1483], 'internalize': [141, 319, 933, 1487, 1631, 3517], 'amounts': [143, 321, 1489, 3507], 'lipid,': [145, 323, 836, 1491], 'may': [147, 325, 1493, 1541, 3516], 'ultimately': [148, 326], 'overwhelm': [149, 327, 1494], 'metabolic': [151, 329, 366, 380, 418, 1496], 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[420, 587, 898, 1419, 1874], 'Invest.': [421, 588], '2011;': [422, 449, 1520], '121:': [423], '2111-2117Crossref': [424], '(1624)': [427], '4Park': [430], 'J.': [431, 564, 945, 1238, 1735, 1755, 2127, 2142, 4324], 'Euhus': [432], 'D.M.': [433], 'Scherer': [434, 470, 952], 'P.E.': [435, 471, 953], 'Paracrine': [436], 'endocrine': [438], 'effects': [439, 1869, 3529], 'on': [443, 2004, 2440, 2597, 2925, 2963, 3129, 3534, 3684, 3707, 4114, 4291, 4351], 'cancer': [444], 'development': [445, 582], 'progression.Endocr.': [447], '32:': [450], '550-570Crossref': [451], '(240)': [454], '5Wernstedt': [457], 'Asterholm': [458], 'I.': [459, 755, 876, 886, 941, 949, 1081, 1122, 1273, 1314, 1397, 1407, 1513, 2823, 2861, 3334, 4336], 'Tao': [460], 'C.': [461, 686, 692, 694, 1085, 1277, 2865, 4334, 4403], 'Morley': [462], 'T.S.': [463], 'Wang': [464, 468, 760], 'Q.A.': [465], 'Delgado-Lopez': [466], 'F.': [467, 1224], 'Z.V.': [469], 'Adipocyte': [472, 768, 2243], 'inflammation': [473, 573], 'essential': [475], 'remodeling.Cell': [482], 'Metab.': [483, 900, 1421, 1876, 2145], '2014;': [484], '20:': [485, 1147, 1339, 2236, 2848, 3359], '103-118Abstract': [486], 'Full': [487, 489, 646, 648, 788, 790, 973, 975, 1070, 1072, 1523, 1525, 2106], 'Text': [488, 490, 647, 649, 789, 791, 974, 976, 1071, 1073, 1524, 1526, 2107], 'PDF': [491, 650, 792, 977, 1074, 1527, 2108], '(437)': [494], 'Scholar).': [496, 732, 797, 908, 982, 1248, 1345, 1429, 1763, 1884, 2111, 2242, 3365], 'Despite': [497], 'this': [498, 985, 1251, 1575, 1597, 2532, 3518], 'importance,': [499], 'our': [500, 3535], 'understanding': [501, 819], 'macrophage-adipocyte': [503, 824, 1594], 'incomplete.': [506], 'It': [507, 829, 3744], 'known': [509, 831], 'transform': [514, 1637], 'into': [515, 839, 1639, 2071, 2329, 2931, 3769, 3881, 3905], 'drive': [519], 'inflammatory': [521, 665, 810, 851, 1537], 'changes': [522, 712, 811], 'occur': [524], 'it': [529, 838, 914, 1638], 'appears': [530], 'play': [533], 'protective': [535], 'role': [536, 579], 'homeostasis,': [539], 'but': [540], 'mount': [541], 'maladaptive': [543, 1536], 'immune': [544], 'response': [545, 4135], 'setting': [548, 911, 1507, 1555], '(6Xu': [551], 'H.': [552, 870, 1391, 1842], 'Barnes': [553], 'G.T.': [554], 'Yang': [555, 559], 'Q.': [556], 'Tan': [557], 'G.': [558, 751, 753, 1200], 'D.': [560, 604, 700, 1159], 'Chou': [561], 'C.J.': [562], 'Sole': [563], 'Nichols': [565], 'A.': [566, 608, 882, 888, 939, 947, 1226, 1403, 1409, 2206, 4309], 'Ross': [567], 'J.S.': [568], 'Tartaglia': [569], 'L.A.': [570, 4401], 'et': [571, 703, 2219, 4404], 'al.Chronic': [572], 'fat': [575, 1695, 1700, 1715, 1770, 1799, 1837, 1887, 2436, 2592], 'plays': [576], 'crucial': [578], 'obesity-related': [584], 'resistance.J.': [586], '2003;': [589], '112:': [590], '1821-1830Crossref': [591], '(5170)': [594], '7Nguyen': [597], 'M.T.': [598], 'Favelyukis': [599], 'S.': [600, 690, 749, 761, 955, 4313, 4395], 'Nguyen': [601], 'A.K.': [602], 'Reichart': [603], 'Scott': [605, 4306], 'P.A.': [606], 'Jenn': [607], 'Liu-Bryan': [609], 'R.': [610, 684, 874, 951, 1155, 1395], 'Neels': [613], 'J.G.': [614], 'Olefsky': [615], 'A': [617, 3407, 3799], 'subpopulation': [618], 'infiltrates': [621], 'hypertrophic': [622, 919], 'activated': [627], 'free': [629, 1100, 1292, 2880], 'fatty': [630, 925, 2043], 'acids': [631, 926], 'via': [632, 1614, 2231, 3175], 'Toll-like': [633], 'receptors': [634], '2': [635, 1909, 2192, 3462, 3605, 3851, 3890], '4': [637, 2187, 2507, 3188], 'JNK-dependent': [639], 'pathways.J.': [640], 'Biol.': [641, 1065, 1110, 1144, 1190, 1212, 1240, 1302, 1336, 2101, 2845, 2890, 3356, 4356], 'Chem.': [642, 1066, 2102], '2007;': [643, 675, 861, 4325], '282:': [644], '35279-35292Abstract': [645], '(773)': [653], '8Lumeng': [656], 'Deyoung': [658, 844], 'S.M.': [659, 845], 'Bodzin': [660, 846], 'J.L.': [661, 702, 847], 'Increased': [664, 850], 'properties': [666, 852], 'recruited': [671, 857], 'during': [672, 858, 1270, 1545, 4251], 'diet-induced': [673, 859], 'obesity.Diabetes.': [674, 860], '56:': [676, 862], '16-23Crossref': [677, 863], '(768)': [680, 866], '9Cancello': [683], 'Henegar': [685], 'Viguerie': [687], 'N.': [688], 'Taleb': [689], 'Poitou': [691], 'Rouault': [693], 'Coupaye': [695], 'M.': [696, 763, 884, 1405], 'Pelloux': [697], 'V.': [698, 2200], 'Hugol': [699], 'Bouillot': [701], 'al.Reduction': [704], 'infiltration': [707], 'chemoattractant': [709], 'gene': [710], 'expression': [711, 2477, 2516, 3020, 4368], 'white': [714, 735], 'morbidly': [718], 'obese': [719, 779], 'subjects': [720], 'after': [721, 2080, 2458], 'surgery-induced': [722], 'weight': [723], 'loss.Diabetes.': [724], '2005;': [725, 785], '54:': [726, 971], '2277-2286Crossref': [727], '(871)': [730], 'Macrophages': [733, 1133, 1325, 1514, 2834, 3285, 3345, 3515], '(WAT)': [738], 'crown-like': [740], 'structures': [741], '(CLSs)': [742], 'encircling': [743], 'or': [745, 1019, 1656, 1698, 1806, 2155, 2373, 2394, 2443, 2942, 2974, 3034, 3155, 3459, 3602, 3618, 3948, 4022, 4043, 4055], 'dying': [746, 1657], '(10Cinti': [748], 'Mitchell': [750], 'Barbatelli': [752], 'Murano': [754, 940], 'Ceresi': [756], 'E.': [757, 759, 943, 1124, 1316, 2825, 3336], 'Faloia': [758], 'Fortier': [762], 'Greenberg': [764], 'A.S.': [765, 1083, 1120, 1275, 1312, 2821, 2863, 3332], 'Obin': [766], 'M.S.': [767], 'death': [769, 2229, 2244], 'defines': [770], 'localization': [772, 1177], 'function': [774, 1203], 'mice': [780, 1671, 1687, 1765, 1789, 2301, 2439], 'humans.J.': [782], 'Lipid': [783, 968], 'Res.': [784, 969], '46:': [786], '2347-2355Abstract': [787], '(1762)': [795], 'Recent': [798], 'studies,': [799], 'involved': [807], 'associated': [812], 'highlight': [815], 'importance': [817], 'biology': [821, 1540], 'within': [826, 3310, 3382, 3576, 3998], 'CLS.': [828], 'CLS': [833, 1563, 1580, 1593, 1602, 3023], 'accumulate': [835], 'transforming': [837], '(8Lumeng': [842], '11Shapiro': [869], 'Pecht': [871, 1392], 'T.': [872, 1393, 4399], 'Shaco-Levy': [873, 1394], 'Harman-Boehm': [875, 1396], 'Kirshtein': [877, 1398], 'B.': [878, 1399], 'Kuperman': [879, 1400], 'Y.': [880, 1401], 'Chen': [881, 1402], 'Bluher': [883, 1404], 'Shai': [885, 1406], 'Rudich': [887, 1408], 'Adipose': [889, 1410], 'present': [894, 1415, 1560], 'obesity.J.': [897, 1418], 'Endocrinol.': [899, 1420, 1875], '2013;': [901, 970, 1422, 2235], '98:': [902, 1423], '1173-1181Crossref': [903, 1424], '(91)': [906, 1427], 'In': [909, 4175], 'proposed': [917], 'release': [921], 'triglycerides': [922], 'nonesterified': [924], 'then': [931, 1903, 1997, 2612, 2705, 3250, 3566, 3746, 3895, 3970], 'passively': [932], 'standard': [935, 4242], 'endocytic': [936, 3521], 'mechanisms': [937, 3522], '(12Giordano': [938], 'Mondini': [942], 'Perugini': [944], 'Smorlesi': [946], 'Severi': [948], 'Barazzoni': [950], 'Cinti': [954], 'Obese': [956], 'ultrastructural': [959], 'features': [960, 1589], 'stressed': [962], 'die': [965], 'pyroptosis.J.': [967], '2423-2436Abstract': [972], '(180)': [980], 'However,': [983], 'study,': [986], 'that,': [989], 'rather': [990, 1992], 'endocytosis': [992], 'lipids,': [995], 'themselves': [998], 'actively': [999], 'participate': [1000], 'lipid': [1002, 2927, 2965], 'liberation': [1003], 'from': [1004, 1674, 1835, 1862, 2299, 2412, 2432, 2437, 2593, 2715, 2786, 3370, 3511, 4123], 'adipocyte.': [1006, 3549], 'Our': [1007], 'laboratory': [1008], 'others': [1010, 4147], 'have': [1011, 1256, 1542], 'described': [1012, 1839, 2074, 2902, 3329, 3475, 4073], 'moieties': [1018], 'species': [1020], 'tightly': [1021], 'bound': [1022], 'matrix': [1026], 'initially': [1028], 'an': [1033, 1135, 1327, 1370, 1577, 1605, 2687, 2747, 2836, 3062, 3118, 3176, 3347, 3494, 3548, 3755, 3770, 3820, 3986, 4099, 4271], 'lytic': [1036], 'compartment': [1037, 1139, 1331, 1609, 2840, 3351], '(13Zhang': [1038], 'W.Y.': [1039], 'Gaynor': [1040], 'P.M.': [1041], 'Kruth': [1042], 'H.S.': [1043], 'Aggregated': [1044, 1090, 1282, 2870], 'low': [1045, 1061, 1171, 1694, 4300], 'density': [1046, 1062, 3923], 'lipoprotein': [1047, 1063], 'induces': [1048, 1096, 1288, 2876], 'enters': [1050], 'surface-connected': [1051], 'monocyte-macrophages.': [1055], 'occurs': [1057, 1269, 1552, 1622, 4250], 'independently': [1058], 'receptor.J.': [1064], '1997;': [1067], '272:': [1068], '31700-31706Abstract': [1069], '(59)': [1077], '14Grosheva': [1080], 'Haka': [1082, 1274, 2862], 'Qin': [1084, 1276, 2864], 'Pierini': [1086, 1129, 1278, 1321, 2830, 2866, 3341], 'L.M.': [1087, 1130, 1279, 1322, 2831, 2867, 3342], 'Maxfield': [1088, 1131, 1280, 1323, 2832, 2868, 3343], 'F.R.': [1089, 1132, 1281, 1324, 2833, 2869, 3344], 'LDL': [1091, 1283, 1350, 2871], 'increases': [1098, 1290, 2878], 'cholesterol': [1101, 1293, 1355, 2881], 'levels': [1102, 1294, 2882, 4301], 'regulate': [1104, 1296, 2884], 'polymerization.Arterioscler.': [1107, 1299, 2887], 'Thromb.': [1108, 1300, 2888], 'Vasc.': [1109, 1301, 2889], '2009;': [1111, 1146, 1303, 1338, 1756, 2847, 2891, 3358], '29:': [1112, 1304, 2892], '1615-1621Crossref': [1113, 1305, 2893], '(33)': [1116, 1308, 2896], '15Haka': [1119, 1311], 'Grosheva': [1121, 1313, 2822, 3333], 'Chiang': [1123, 1315, 2824, 3335], 'Buxbaum': [1125, 1317, 2826, 3337], 'Baird': [1127, 1319, 2828, 3339], 'B.A.': [1128, 1320, 2829, 3340], 'create': [1134, 1326, 2835, 3346], 'digest': [1141, 1333, 2842, 3353], 'aggregated': [1142, 1266, 1334, 1349, 2843, 3354], 'lipoproteins.Mol.': [1143, 1335, 2844, 3355], 'Cell.': [1145, 1337, 2846, 3357], '4932-4940Crossref': [1148, 1340, 2849, 3360], '(88)': [1151, 1343, 2852, 3363], '16Baron': [1154], 'Neff': [1156], 'L.': [1157], 'Louvard': [1158], 'Courtoy': [1160], 'P.J.': [1161], 'Cell-mediated': [1162], 'acidification': [1164], 'bone': [1166], 'resorption:': [1167], 'evidence': [1168, 1561], 'pH': [1172, 3295, 3301, 3308], 'resorbing': [1174], 'lacunae': [1175], '100-kD': [1180], 'membrane': [1182, 2472, 2474, 2752, 2816, 2905, 2955, 3469, 4067, 4287, 4341, 4383], 'protein': [1183], 'osteoclast': [1186, 1236], 'ruffled': [1187, 1206], 'border.J.': [1188], 'Cell': [1189, 1210, 1239, 2323, 3385, 4355], '1985;': [1191, 2103], '101:': [1192], '2210-2222Crossref': [1193], '(595)': [1196], '17Stenbeck': [1199], 'Formation': [1201], 'border': [1207], 'osteoclasts.Semin.': [1209], 'Dev.': [1211], '2002;': [1213, 1877], '13:': [1214], '285-292Crossref': [1215], '(97)': [1218], '18Jurdic': [1221], 'P.': [1222, 4311], 'Saltel': [1223], 'Chabadel': [1225], 'Destaing': [1227], 'O.': [1228], 'Podosome': [1229], 'sealing': [1231], 'zone:': [1232], 'specificity': [1233], 'model.Eur.': [1237], '85:': [1242], '195-202Crossref': [1243], '(287)': [1246], 'exophagy.': [1254, 3525], 'exophagy': [1258, 1440, 1663, 4249], 'context': [1261], 'LDL,': [1267], 'atherogenesis': [1271], '(14Grosheva': [1272, 2860], 'Exophagic': [1346], 'catabolism': [1347, 1454, 1617], 'results': [1351, 4152], 'uptake': [1353, 1457], 'macrophage,': [1358, 1500], 'leading': [1359, 1533], 'While': [1364], 'area': [1371, 3780, 3807], 'extensive': [1373], 'study': [1374], 'atherosclerosis': [1377, 1509], 'field,': [1378, 2739], 'CLSs': [1384, 4266], 'only': [1386, 3540], 'reported': [1388], 'recently': [1389], '(11Shapiro': [1390], 'Given': [1430], 'similarities': [1432], 'these': [1434, 1624], 'two': [1435, 3376, 4166], 'systems,': [1436], 'examined': [1438, 1826, 4259], 'whether': [1439, 4248], 'could': [1441], 'responsible': [1443], 'adipocytes.': [1449, 1474, 2011, 3306, 3514], 'would': [1451, 1987], 'allow': [1452, 2922], 'subsequent': [1456], 'pieces': [1459, 1632], 'adipocyte,': [1462], 'facilitating': [1463], 'consequence': [1470], 'clearing': [1472], 'demonstrated': [1504], '(19Moore': [1510], 'K.J.': [1511], 'Tabas': [1512], 'pathogenesis': [1517], 'atherosclerosis.Cell.': [1519], '145:': [1521], '341-355Abstract': [1522], '(1801)': [1530], 'Scholar),': [1532, 4364], 'response.': [1538, 4160], 'particular': [1543], 'relevance': [1544], 'dramatically': [1548], 'enlarged': [1549], 'obesity.': [1557, 4276], 'Herein,': [1558], 'exophagic': [1565], 'WAT.': [1572], 'To': [1573, 2028, 2112, 2176, 2468, 3016, 3526, 4033, 4246], 'model': [1574, 1583, 4274], 'biology,': [1576], 'vitro': [1579, 2332], 'was': [1584, 1771, 1800, 1934, 2245, 2362, 2445, 2520, 2600, 2672, 2704, 2730, 2762, 2776, 2791, 2909, 3001, 3094, 3105, 3173, 3207, 3313, 3387, 3410, 3470, 3496, 3539, 3565, 3728, 3745, 3767, 3783, 3801, 3817, 3903, 3988, 4068, 4104, 4173, 4180, 4186, 4191], 'developed': [1585], 'mirrors': [1587], 'several': [1588], 'vivo': [1592], 'interactions.': [1595], 'demonstrate': [1600], 'containing': [1610, 1894, 2009, 2040, 2337, 2366, 2422, 3639], 'Initial': [1616], 'compartments,': [1626], 'allowing': [1627], 'cell.': [1642, 2755], 'specific': [1651], 'blocked': [1661], 'when': [1662], 'inhibited.': [1665], 'C57BL/6J': [1666, 1787], 'wild-type': [1667], 'male': [1668, 1686, 2438, 2595], 'female': [1670, 1750, 1753, 1788], 'were': [1672, 1688, 1766, 1809, 1822, 1825, 1833, 1897, 1946, 1967, 1996, 2014, 2036, 2052, 2069, 2116, 2159, 2180, 2271, 2302, 2327, 2377, 2410, 2430, 2482, 2498, 2534, 2565, 2571, 2624, 2643, 2656, 2899, 2969, 3029, 3059, 3127, 3136, 3185, 3227, 3249, 3268, 3286, 3368, 3397, 3427, 3440, 3444, 3479, 3555, 3585, 3611, 3632, 3675, 3690, 3700, 3835, 3879, 3935, 3961, 4007, 4048, 4076, 4117, 4213, 4238], 'purchased': [1673, 2411, 2431], 'Jackson': [1675], 'Laboratory': [1676], '(Bar': [1677], 'Harbor,': [1678], 'ME).': [1679], 'At': [1680, 1781], '6': [1681], 'weeks': [1682, 1783], 'age,': [1684, 1785], 'all': [1685, 2356, 3572, 3994], 'randomized': [1689], 'receive': [1691], 'either': [1692, 2117, 2910, 3147], 'diet': [1696, 1701], '(LFD)': [1697], 'high': [1699], '(HFD)': [1702], '12': [1704, 2466, 2490, 2621], 'weeks.': [1705, 1795], 'LFD': [1707, 2442], '(12450Bi)': [1708], 'HFD': [1710, 1792, 2444, 2599], '(D12492i)': [1711], '10': [1713, 1794, 1940, 2183, 2196, 2342, 2584, 3234, 3265, 3931], 'kcal%': [1714, 1718], '60': [1717, 3078, 3289, 3761], 'fat,': [1719], 'respectively': [1720], '(Research': [1721], 'Diets,': [1722], 'New': [1723], 'Brunswick,': [1724], 'NJ)': [1725, 1912], 'commonly': [1728], 'used': [1729, 2077, 2530, 2566, 3095, 3836, 3955, 4028], 'studies': [1731], '(20Hong': [1734], 'Stubbins': [1736], 'R.E.': [1737], 'Smith': [1738], 'R.R.': [1739], 'Harvey': [1740], 'A.E.': [1741], 'Nunez': [1742], 'N.P.': [1743], 'Differential': [1744, 1857], 'susceptibility': [1745], 'male,': [1749], 'ovariectomized': [1752, 1786], 'mice.Nutr.': [1754], '8:': [1757], '11Crossref': [1758], '(190)': [1761], 'Male': [1764], 'euthanized': [1767], 'epididymal': [1769, 1836, 1886, 2435, 2591], 'removed': [1772, 1801], 'fixed': [1774, 3037, 3251, 3480, 3633, 3962, 4077], '1%': [1776, 2461, 3041, 3262, 3482, 3650, 3964, 4079], 'formalin': [1777, 2462], 'immunofluorescence': [1779, 1805], 'analysis.': [1780, 3915], '5': [1782, 2660, 2662, 3044, 3763], 'received': [1790], 'Following': [1796], 'euthanization,': [1797], 'mammary': [1798], 'stained': [1803, 2573], 'paraffin': [1807, 1820], 'blocks': [1808, 1821], 'prepared': [1810], 'hematoxylin': [1812], 'eosin': [1814], '(H&E)': [1815], 'staining.': [1816, 1829, 3561], 'For': [1817, 2355, 2509, 2586, 2666, 2756, 3124, 3625, 3718], 'each': [1818, 2728, 2799, 3311, 3491, 3553, 3983, 4124], 'patient,': [1819], 'prepared.': [1823], 'Samples': [1824, 3960, 4075], 'H&E': [1828], 'Primary': [1830, 2012], 'murine': [1831, 2479, 3451, 3620, 3939], 'isolated': [1834, 2298], 'previously': [1840, 2075, 3330], '(21Motoshima': [1841], 'Wu': [1843], 'X.': [1844], 'Sinha': [1845], 'M.K.': [1846], 'Hardy': [1847], 'V.E.': [1848], 'Rosato': [1849, 1853], 'E.L.': [1850, 4305], 'Barbot': [1851], 'D.J.': [1852], 'F.E.': [1854], 'Goldstein': [1855], 'B.J.': [1856], 'regulation': [1858], 'adiponectin': [1860], 'secretion': [1861], 'cultured': [1863, 2053], 'omental': [1865], 'subcutaneous': [1867], 'adipocytes:': [1868], 'rosiglitazone.J.': [1873], '87:': [1878], '5662-5667Crossref': [1879], '(361)': [1882], 'Briefly,': [1885], 'DMEM/F-12': [1889, 1955], 'medium': [1890, 2312, 2361], '(Invitrogen,': [1891], 'Carlsbad,': [1892], 'CA)': [1893, 2172], '1.0%': [1895], 'BSA': [1896, 2045], 'chopped': [1898], 'surgical': [1900], 'scissors': [1901], '0.2%': [1906], 'collagenase': [1907], 'type': [1908], '(Worthington,': [1910], 'Lakewood,': [1911], '25': [1914, 2120, 2367], 'min': [1915, 1941, 2920, 2950, 3224, 3235, 3290, 3455, 3598, 3968, 4018], '37°C.': [1917, 2293], 'After': [1918, 2492], 'passing': [1919], 'mixture': [1921], 'through': [1922, 3661], '200': [1924, 3215, 3230, 3854], 'μm': [1925, 3789], 'mesh': [1926], 'filter': [1927], 'remove': [1929, 3423], 'undigested': [1930], 'filtrate': [1933], 'centrifuged': [1935], '100': [1937], 'g': [1938], '4°C.': [1943], 'Separated': [1944], 'collected': [1947], 'disposable': [1950], 'transfer': [1951], 'pipette,': [1952], 'washed': [1953, 1998], 'medium,': [1956], 'attached': [1958, 3729], 'poly-D-lysine-coated': [1960, 3130], 'coverslip': [1961, 2019, 2156, 3132], 'dishes': [1962, 1966, 2020, 2035, 2158], 'microscopy.': [1964], 'Coverslip': [1965], 'functionalized': [1968, 2018], '6.15': [1970], 'mg/ml': [1971, 2042, 2987, 3009, 3182], 'Bis(NHS)PEO5': [1972], '(Pierce,': [1973], 'Rockford,': [1974], 'IL)': [1975], 'PBS': [1977, 3049], '(pH': [1978, 2023], '9.0)': [1979], '1': [1981, 2026, 2047, 2174, 2451, 2575, 2606, 2995, 3014, 3055, 3788, 3863], 'h': [1982, 2125, 2188, 2193, 2452, 2607, 3178, 3189, 3944], 'primary': [1985, 2010, 2485, 2528, 3450, 3619, 3938], 'adhere': [1988], 'dish': [1991, 3172], 'float.': [1994], 'Dishes': [1995], 'HBSS,': [2000], 'inverted,': [2001], 'placed': [2003], 'top': [2005], 'cuvette': [2008], 'incubated': [2015, 2037, 2118, 2181, 2446, 2483, 2499, 2613, 3030, 3047, 3082, 3194, 3228, 3287, 3445, 3586, 3612, 3936, 4008, 4049], 'inverted': [2017, 2688], 'HBSS': [2022], '7.8)': [2024], 'h.': [2027, 2048, 2175, 2467, 2491, 2508, 2622, 2996, 3015, 3056, 4063], 'quench': [2029], 'any': [2030, 3240], 'unreacted': [2031], 'N-hydroxysuccinimidyl': [2032], 'ester': [2033], '(NHS)': [2034], 'DMEM': [2039, 2055, 2274, 2365, 2993, 3012, 3191], '50': [2041, 2061, 2065, 2279, 2283], 'acid-free': [2044], '3T3': [2049, 3615, 4052, 4058], 'L1': [2050, 3616, 4053, 4059], 'fibroblasts': [2051], 'supplemented': [2056, 2275, 2313], '10%': [2058, 2277, 2338, 3051], 'calf': [2059], 'serum,': [2060], 'units/ml': [2062, 2280], 'penicillin,': [2063, 2281], 'μg/ml': [2066, 2284, 2576], 'streptomycin.': [2067], 'Cells': [2068, 3184, 3226, 3248], 'differentiated': [2070, 2303, 2328], '7–10': [2078], 'days': [2079, 2306, 4116], 'differentiation': [2081], '(22Frost': [2082], 'S.C.': [2083], 'Lane': [2084], 'M.D.': [2085], 'Evidence': [2086], 'involvement': [2089], 'vicinal': [2091], 'sulfhydryl': [2092], 'groups': [2093], 'insulin-activated': [2095], 'hexose': [2096], 'transport': [2097], '3T3-L1': [2099], 'adipocytes.J.': [2100], '260:': [2104], '2646-2652Abstract': [2105], 'induce': [2113, 2177], 'apoptosis,': [2114], 'nM': [2121], 'TNF-α': [2122], '24': [2124, 3943, 4062], '(23Lin': [2126], 'Page': [2128], 'K.A.': [2129], 'Della-Fera': [2130], 'M.A.': [2131], 'Baile': [2132], 'C.A.': [2133], 'Evaluation': [2134], 'apoptosis': [2137], 'laser': [2139, 2630, 3142, 3275], 'scanning': [2140, 2631, 3143, 3276, 3722, 3732], 'cytometry.Int.': [2141], 'Obes.': [2143], 'Relat.': [2144], 'Disord.': [2146], '2004;': [2147], '28:': [2148], '1535-1540Crossref': [2149], '(15)': [2152], 'Scholar)': [2154, 2854, 2898], 'bottom': [2157, 3133], 'exposed': [2160], '365': [2162], 'nm': [2163, 3679, 3873], 'UV': [2164], 'radiation': [2165], '2UV': [2168], 'Transilluminator': [2169], '(UVP,': [2170], 'Upland,': [2171], 'pyroptosis,': [2178], 'ng/ml': [2184, 2343], 'lipopolysaccharide': [2185], 'followed': [2189, 2911], 'incubation': [2194, 2334, 2981], 'μM': [2197, 3216, 3231, 3463, 3606], 'nigericin': [2198], '(24Sagulenko': [2199], 'Thygesen': [2201], 'S.J.': [2202], 'Sester': [2203], 'D.P.': [2204], 'Idris': [2205], 'Cridland': [2207], 'J.A.': [2208], 'Vajjhala': [2209], 'P.R.': [2210], 'Roberts': [2211], 'T.L.': [2212], 'Schroder': [2213], 'K.': [2214], 'Vince': [2215], 'J.E.': [2216], 'Hill': [2217], 'al.AIM2': [2220], 'NLRP3': [2222], 'inflammasomes': [2223], 'activate': [2224], 'pyroptotic': [2228], 'pathways': [2230], 'ASC.Cell': [2232], 'Death': [2233], 'Differ.': [2234], '1149-1160Crossref': [2237], '(342)': [2240], 'confirmed': [2246], 'propidium': [2248], 'iodide': [2249], 'staining,': [2250, 2744, 2805], 'performed': [2251, 2900, 4105], 'according': [2252, 3974, 4087], "manufacturer's": [2255, 3977, 4090], 'protocol': [2256, 4190], '(Clontech,': [2257], 'Moutainview,': [2258], 'CA).': [2259], 'J774a.1': [2260], 'RAW264.7': [2262, 3609], 'macrophage-like': [2263], '(American': [2265], 'Type': [2266], 'Culture': [2267], 'Collection,': [2268], 'Manassas,': [2269], 'VA)': [2270], 'maintained': [2272, 3388], 'FBS,': [2278], 'streptomycin': [2285], 'humidified': [2288], 'atmosphere': [2289], '(5%': [2290], 'CO2)': [2291], 'Bone': [2294], 'marrow-derived': [2295], '(BMMs)': [2297], 'C57BL/6': [2300], '7': [2305, 2353, 3431, 3433], 'same': [2311], '20%': [2315], 'L-929': [2316], 'cell-conditioned': [2317], 'medium.': [2318], 'Human': [2319], 'monocytes': [2320], '(Life': [2321], 'Line': [2322], 'Technology,': [2324], 'Frederick,': [2325], 'MD)': [2326], 'RPMI': [2336], 'heat-inactivated': [2339], 'FBS': [2340, 2449], 'colony': [2345], 'stimulating': [2346], 'factor': [2347, 3888], '(R&D': [2348], 'Systems,': [2349], 'Minneapolis,': [2350], 'MN)': [2351], 'days.': [2354], 'live': [2357, 3035, 4042], 'imaging': [2359, 3104], 'experiments,': [2360], 'changed': [2363], 'mM': [2368], 'HEPES': [2369], 'without': [2370, 3038], 'phenol': [2371], 'red': [2372], 'sodium': [2374], 'bicarbonate.': [2375], 'labeled': [2378, 2970, 3060, 3471, 3971, 4069, 4084], 'succinimidyl': [2380, 2978], 'esters': [2381, 2979], 'AlexaFluor': [2383], '(Alexa)546': [2384], 'Alexa488': [2386, 3299, 3414], '(Invitrogen),': [2387], 'FITC,': [2388], 'biotin': [2389, 2975, 3232], '(Sigma-Aldrich,': [2390], 'St.': [2391, 2400], 'Louis,': [2392], 'MO),': [2393], 'CypHer': [2395, 3292], '5E': [2396, 3293], '(GE': [2397], 'Healthcare,': [2398], 'Chalfont': [2399], 'Giles,': [2401], 'UK).': [2402], 'Alexa546-biocytin,': [2403], 'Alexa488-cholera': [2404], 'toxin': [2405], 'B': [2406], '(CtB),': [2407], 'LipidTOX-Red': [2409, 3973, 4086], 'Invitrogen.': [2413], 'Streptavidin,': [2414], 'bafilomycin': [2415, 3464, 3607], 'A1,': [2416], 'protease': [2418, 3952, 4025], 'inhibitor': [2419, 3953, 4026], 'cocktail': [2420, 3954, 4027], '(P1860),': [2421], 'aprotinin,': [2423], 'bestatin,': [2424], 'E-64,': [2425], 'leupeptin,': [2426], 'pepstatin': [2428], 'A,': [2429], 'Sigma-Aldrich.': [2433], 'Whole-mounted': [2434], '5%': [2448], 'room': [2454, 2504, 2581, 2609], 'temperature': [2455, 2505, 2582, 2610, 3386], 'blocking': [2457], 'fixation': [2459, 2913], '4°C': [2464, 2488, 2619], 'analyze': [2469], 'plasma': [2471, 2751, 2954, 3468, 4066, 4286, 4353, 4382], 'lysosome-associated': [2473], 'protein-1': [2475], '(LAMP-1)': [2476], 'levels,': [2478, 2517], 'tissues': [2481], 'antibodies': [2486, 2502, 2529], 'three': [2493], 'washes': [2494], 'PBS,': [2496], 'samples': [2497, 3478], 'secondary': [2501, 2568], 'detection': [2511, 2588], 'LAMP-1': [2515, 2535, 2667, 2713, 2725, 2753, 2784, 2789, 2812, 3019, 3065, 3100, 3103, 4288, 4290, 4367], 'treated': [2521, 2601, 3656], '0.3%': [2523, 2603], 'Triton': [2524, 2604, 3263], 'permeabilization.': [2526, 3247], 'experiment': [2533], '(1:2,000,': [2536, 2542, 2550], 'ab24170;': [2537], 'Abcam,': [2538], 'Cambridge,': [2539], 'MA),': [2540], 'F4/80': [2541, 2681, 2771], 'MCA497R;': [2543], 'AbD': [2544], 'Serotec,': [2545], 'Raleigh,': [2546], 'NC),': [2547], 'calnexin': [2549, 2721], 'ab192439;': [2551], 'Abcam).': [2552], 'Anti-rabbit-cy3': [2553], '(1:2,000),': [2554, 2556], 'anti-rat-FITC': [2555], 'anti-goat-cy5': [2558], '(1:2,000)': [2559], '(Jackson': [2560], 'ImmunoResearch,': [2561], 'West': [2562], 'Grove,': [2563], 'PA)': [2564, 3595], 'antibodies.': [2569], 'Tissues': [2570], 'next': [2572], '4′,6-diamidino-2-phenylindole': [2577], '(DAPI)': [2578], '(Invitrogen)': [2579], 'min.': [2585, 3090, 3201, 3266, 3486, 3624], 'F-actin,': [2590], 'Alexa488-phalloidin': [2615, 2859], '(1:200,': [2616], 'Invitrogen)': [2617], 'Images': [2623, 2655, 3135, 3267, 3426, 3699, 3878], 'acquired': [2625, 3137, 3269, 3701, 4113], 'Zeiss': [2628, 3140, 3272], 'LSM510': [2629, 3141], 'confocal': [2632, 3144, 3277], 'microscope': [2633, 3145, 3278, 3713], '40×': [2636, 3149, 3281], '0.8': [2637, 3150, 3282], 'numerical': [2638], 'aperture': [2639], '(NA)': [2640], 'objective.': [2641, 3162, 3284], 'Data': [2642, 4112], 'analyzed': [2644, 3398], 'MetaMorph': [2646, 3400], 'image': [2647, 2729, 3401, 3554], 'analysis': [2648, 3402, 4103], 'software,': [2649, 3403], 'Molecular': [2650, 3404], 'Devices': [2651, 3405], 'Corporation': [2652], '(Downingtown,': [2653], 'PA).': [2654], 'convolved': [2657, 3428], '×': [2661, 3432], 'pixel': [2663, 3312, 3434, 3574, 3996], 'Gaussian': [2664, 3435], 'filter.': [2665], 'analysis,': [2668], 'binary': [2670, 2689, 2760, 3408], 'mask': [2671, 2690, 2703, 2761, 2775, 3409], 'created': [2673, 2691, 2763, 3411], 'FITC': [2676, 2766], 'signal': [2677, 2726, 2767, 2790, 3114, 3415, 3489, 3538, 3981], 'intensity,': [2678], 'select': [2680, 2697, 2770], 'positive': [2682, 2719, 2772], 'cells,': [2683], 'multiplied': [2685], 'Cy5': [2694], 'signal,': [2695], 'calnexin-negative': [2698], 'nonpermeabilized': [2699, 2716], 'cells.': [2700, 2773], 'resultant': [2702], 'applied': [2706, 2777, 3418], 'Cy3': [2709, 2780], 'channel': [2710, 2781], 'isolate': [2712, 2783], 'signals': [2714, 2785], '(F4/80': [2718], 'negative).': [2722], 'surface': [2724, 3018, 3560, 4293, 4366], 'divided': [2731, 2792], 'number': [2734, 2795], 'determined': [2741, 2802], 'DAPI': [2743, 2804], 'generate': [2746], 'average': [2748], 'value': [2749, 2809, 3309, 4130], 'per': [2754, 2813, 4096], 'permeabilized': [2757, 3260], 'tissues,': [2758], 'intensity': [2768, 3416, 4095], 'image,': [2800], 'calculate': [2807], 'Plasma': [2815, 2904], 'labeling': [2817, 2857, 2906, 2998, 3164], 'Alexa488-CtB': [2819, 3558, 4071], '(15Haka': [2820, 3331], 'F-actin': [2856], 'previously.': [2903], 'Alex488-CtB': [2908], '3%': [2915, 2943, 3074, 3253], 'paraformaldehyde': [2916], '(PFA)': [2917], '15': [2919, 3256, 3485, 3967, 4082], '(to': [2921, 2951, 3112], 'CtB': [2924, 2962], 'its': [2926, 2964], 'receptor': [2928], 'redistribute': [2930], 'sealed': [2933], 'zone': [2934], 'following': [2940, 3843], 'fixation)': [2941], 'PFA': [2944, 3042, 3254, 3483, 3965, 4080], '0.5%': [2946], 'glutaraldehyde': [2947], '30': [2949, 3089, 3211], 'avidly': [2952], 'cross-link': [2953], 'proteins': [2956, 4315], 'preventing': [2957], 'postfixation': [2958], 'diffusion': [2959], 'receptor).': [2966], 'Apoptotic': [2967], 'various': [2972], 'fluorophores': [2973], 'conjugated': [2976, 2990], '0.02': [2986], 'fluorophore': [2991], 'Streptavidin': [2997], 'accomplished': [3002, 3174, 3208], 'incubating': [3004], 'biotin-labeled': [3005], '0.5': [3008], 'streptavidin': [3010, 3242], 'determine': [3017], 'J774': [3027, 3442, 3583, 3933, 4005, 4046], 'permeabilization': [3039], 'min,': [3045, 3079, 3257, 4083], 'goat': [3052, 3075], 'serum': [3053, 3076], 'Next,': [3057], 'antibody': [3063, 3093], 'against': [3064], '(Abcam)': [3066], '1:125': [3068], 'dilution': [3069, 3087], 'presence': [3072, 3458, 3601, 3947, 4021, 4040], 'washed,': [3080, 3258], 'anti-rabbit-Alexa488': [3084], '1:250': [3086], 'An': [3091, 3779], 'irrelevant': [3092], 'control': [3098, 4129], 'immunostaining.': [3101], 'Surface': [3102], 'carried': [3106], 'out': [3107], 'pinholes': [3110], 'open': [3111], 'improve': [3113], 'collection)': [3115], 'resulting': [3116], 'axial': [3119], 'resolution': [3120], '14': [3122], 'μm.': [3123], 'imaging,': [3125], 'plated': [3128, 3167], 'glass': [3131], 'dishes.': [3134], 'NA': [3151, 3159, 3283], 'plan': [3152, 3160], 'Apochromat': [3153, 3161], 'objective': [3154], '63×': [3157], '1.4': [3158], 'Lysosome': [3163], 'tri-partitioned': [3170], 'Petri': [3171], '18': [3177], 'pulse': [3179, 3213], '2.2': [3181], 'biotin-fluorescein-dextran.': [3183], 'chased': [3186], 'subsequently': [3193], 'streptavidin-labeled': [3197], '90': [3200, 3223, 3454, 3597, 3623, 4017], 'Labeling': [3202], 'streptavidin-conjugated': [3205], 's': [3212], 'Alexa546-biocytin': [3217], 'end': [3220], 'incubation.': [3225], 'order': [3237], 'bind': [3239], 'unoccupied': [3241], 'sites': [3243], 'prior': [3244], 'LSM': [3273], '510': [3274], '(a': [3294, 3300], 'sensitive': [3296], 'fluorophore)': [3297, 3303], 'insensitive': [3302], 'dual-labeled': [3304], 'assessed': [3314], 'quantitatively': [3315], 'comparison': [3317], 'ratio': [3319, 3438], 'images': [3320, 3439, 3840], 'obtained': [3321], 'calibration': [3323, 3372], 'buffers': [3324], 'varying': [3326], 'pH,': [3327], 'Nuclear': [3366], 'regions': [3367], 'excluded': [3369], 'curve,': [3373], 'dyes': [3377], 'accumulated': [3378], 'different': [3380, 4115], 'rates': [3381], 'nucleus.': [3384], '37°C': [3390], 'heated': [3393], 'stage.': [3394], 'All': [3395], 'data': [3396, 4122, 4179], 'Corporation.': [3406], 'channels': [3421], 'background': [3424], 'noise.': [3425], 'filter,': [3436], 'generated.': [3441], 'Alexa546-labeled': [3447], 'TNF-α-induced': [3448, 4056], 'absence': [3460, 3603, 3949, 4023], 'A1.': [3465, 3608], 'Alexa488-CtB,': [3473], 'above,': [3476], 'Alexa546': [3488, 3537], 'touching': [3493, 3985, 4098], 'quantified.': [3497, 4101], 'note': [3499], 'coculture': [3502], 'system': [3503, 3795], 'often': [3504], 'contains': [3505], 'small': [3506], 'debris': [3510, 3519, 3533], 'other': [3523], 'minimize': [3527], 'adiopcyte': [3531], 'results,': [3536], 'quantified': [3541, 4284], 'those': [3543], 'identified': [3556], 'fluorescence': [3563], 'power': [3564], 'calculated': [3567, 3989], 'sum': [3570, 3992, 4171], 'intensities': [3575, 3997], 'boundaries.': [3579, 4001], 'As': [3580, 4002, 4277], 'control,': [3582, 4004], 'Fluoresbrite': [3588, 4010], 'YG': [3589, 4011], 'latex': [3590, 4012], 'beads': [3591, 4013], '(Polysciences,': [3592, 4014], 'Inc.,': [3593], 'Warrington,': [3594], 'transmission': [3626], 'electron': [3627, 3712, 3821, 3922], 'microscopy': [3628], '(EM),': [3629], 'modified': [3636], "Karnovsky's": [3637], 'solution': [3638], '2.5%': [3640], 'glutaraldehyde,': [3641], '4%': [3642], 'PFA,': [3643], '0.02%': [3645], 'picric': [3646], 'acid,': [3647], 'postfixed': [3648], 'osmium': [3651], 'tetroxide,': [3652], '1.5%': [3653], 'potassium': [3654], 'ferricyanide,': [3655], 'uranyl': [3658, 3694], 'acetate,': [3659], 'dehydrated': [3660], 'graded': [3663], 'ethanol': [3664], 'series,': [3665], 'embedded': [3667], 'LX112': [3669], 'resin.': [3670], 'En': [3671], 'face': [3672, 3816], 'serial': [3673, 3839], 'sections': [3674], 'cut': [3676], '70': [3678], 'thickness': [3680], 'picked': [3682], 'up': [3683], 'formvar-coated': [3685], '4-slot': [3686], 'copper': [3687], 'grids.': [3688], 'Sections': [3689], 'further': [3691], 'contrasted': [3692], 'acetate': [3695], 'lead': [3697], 'citrate.': [3698], 'Weill': [3703, 4202, 4226], 'Cornell': [3704, 4203, 4227], 'Medical': [3705, 4204, 4228], 'College': [3706, 4205], 'JEOL': [3709], 'JEM': [3710], '100CX-II': [3711], 'operating': [3714], '80': [3716], 'kV.': [3717], '3D': [3719], 'focused-ion': [3720], 'beam': [3721, 3822], 'EM': [3723, 3733], '(FIB-SEM),': [3724], 'resin': [3726], 'block': [3727], 'stub': [3734], 'double-sided': [3736], 'carbon': [3737], 'tape': [3738], 'painted': [3740], 'colloidal': [3742], 'silver.': [3743], 'coated': [3747, 3786], 'thin': [3750], 'layer': [3751], 'Au/Pd': [3753], 'Ar': [3756], 'environment': [3757], '(25': [3758], 'mA': [3759], 'current,': [3760, 3853], 'mtorr,': [3762], 'min).': [3764], 'sample': [3766], 'loaded': [3768], 'FEI': [3771, 3829], 'Helios': [3772], 'Nanolab': [3773], '650': [3774], 'FIB-SEM': [3775], 'ion-abrasion': [3777], 'tomography.': [3778], 'interest': [3782], 'found': [3784], 'Pt': [3790], 'gas': [3793], 'injection': [3794], 'microscope.': [3798], 'trench': [3800], 'dug': [3802], 'front': [3804], 'ion': [3810], 'beam.': [3811], 'Imaging': [3812], 'cross-sectional': [3815], 'done': [3818], 'viewing': [3823], 'angle': [3824], '−30': [3826], 'degrees.': [3827], 'Slice': [3830], 'View': [3832], 'G2': [3833], 'programs': [3834], 'collect': [3838], 'parameters:': [3844], 'working': [3845], 'distance,': [3846], '2.4': [3847], 'mm;': [3848], 'landing': [3849], 'energy,': [3850], 'keV;': [3852], 'pA;': [3855], 'horizontal': [3856], 'field': [3857], 'width,': [3858], '41': [3859], 'μm;': [3860], 'dwell': [3861], 'time,': [3862], 'μs;': [3864], '4×': [3865], 'integration;': [3866], '4096': [3867], 'pixels': [3868], 'across': [3869], '(10': [3870], 'nm/pixel);': [3871], '20': [3872], 'slice': [3874], 'width;': [3875], '1,500': [3876], 'images.': [3877], 'stacked': [3880], 'single': [3883], 'file,': [3884], 'shrunk': [3885], 'X': [3892], 'Y': [3894], 'aligned': [3896, 3901], 'IMOD': [3898], 'tools.': [3899], 'stack': [3902], 'imported': [3904], 'Imaris': [3906], '(Bitplane,': [3907], 'Oxford': [3908], 'Instruments,': [3909], 'Concord,': [3910], 'MA)': [3911], 'segmentation': [3913], 'Sealed': [3916], 'contained': [3918], 'no': [3919], 'gap': [3920], '(resolution': [3930], 'nm).': [3932], '1:800': [3958, 4031], 'dilution.': [3959, 4032], 'protocol.': [3978, 4245], 'LipidTOX': [3980, 4094], 'Inc.)': [4015], 'examine': [4034], 'untreated': [4051], 'above.': [4074], 'protocol,': [4091], 'Statistical': [4102], 'Matlab': [4107], 'R2012A': [4108], '(Mathworks,': [4109], 'Natick,': [4110], 'MA).': [4111], 'compared': [4118], 'normalizing': [4120], 'day': [4125], 'median': [4128], 'day.': [4133], 'heterogeneous,': [4140], 'some': [4142], 'responding': [4144], 'vigorously': [4145], 'all.': [4150], 'nonnormal': [4155], 'distribution': [4156], 'Thus,': [4161], 'comparisons': [4164], 'groups,': [4167], 'Wilcoxon': [4169], 'rank': [4170], 'test': [4172], 'used.': [4174], 'experiments': [4176], 'where': [4177], 'normally': [4181, 4297], 'distributed,': [4182], "Student's": [4184], 't-test': [4185], 'performed.': [4187], 'animal': [4189], 'approved': [4192, 4214], 'Institutional': [4195, 4217], 'Animal': [4196], 'Care': [4197], 'Use': [4199], 'Committee': [4200], '(New': [4206], 'York,': [4207], 'NY).': [4208], 'Studies': [4209], 'involving': [4210], 'Review': [4218], 'Boards': [4219], 'Memorial': [4221, 4234], 'Sloan-Kettering': [4222, 4235], 'Cancer': [4223, 4236], 'Center': [4224, 4237], 'College.': [4229], 'Women': [4230], 'undergoing': [4231], 'mastectomy': [4232], 'consented': [4239], 'under': [4240], 'acquisition': [4244], 'see': [4247], 'first': [4258], 'amount': [4261], 'lysosome': [4263, 4281], 'exocytosis': [4264], 'resident': [4268], 'established': [4272], 'marker': [4279, 4375], 'exocytosis,': [4282], 'levels.': [4289], 'extremely': [4299], '(25Huynh': [4302], 'K.K.': [4303], 'Eskelinen': [4304], 'C.C.': [4307], 'Malevanets': [4308], 'Saftig': [4310], 'Grinstein': [4312], 'LAMP': [4314], 'required': [4317], 'fusion': [4319, 4377, 4407], 'lysosomes': [4321, 4346, 4379], 'phagosomes.EMBO': [4323], '26:': [4326], '313-324Crossref': [4327], '(468)': [4330], '26Harter': [4333], 'Mellman': [4335], 'Transport': [4337], 'glycoprotein': [4342], 'lgp120': [4343], '(lgp-A)': [4344], 'does': [4347], 'require': [4349], 'appearance': [4350], 'membrane.J.': [4354], '1992;': [4357], '117:': [4358], '311-325Crossref': [4359], '(208)': [4362], 'shown': [4371], '(27Colvin': [4384], 'R.A.': [4385], 'Means': [4386], 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