Publication Information

{'id': 'https://openalex.org/W2316038256', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-1892', 'title': 'Abstract 1892: Integrated energetics and flux analysis reveals differential metabolic reprogramming in highly and less invasive cancer cells.', 'display_name': 'Abstract 1892: Integrated energetics and flux analysis reveals differential metabolic reprogramming in highly and less invasive cancer cells.', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2316038256', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-1892', 'mag': '2316038256'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-1892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062386210', 'display_name': 'Abhinav Achreja', 'orcid': 'https://orcid.org/0000-0002-1773-6490'}, 'institutions': [{'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Abhinav Achreja', 'raw_affiliation_strings': ['1Rice Univ., Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1Rice Univ., Houston, TX;', 'institution_ids': ['https://openalex.org/I74775410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025588089', 'display_name': 'Lifeng Yang', 'orcid': 'https://orcid.org/0000-0001-5175-7589'}, 'institutions': [{'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lifeng Yang', 'raw_affiliation_strings': ['1Rice Univ., Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1Rice Univ., Houston, TX;', 'institution_ids': ['https://openalex.org/I74775410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102727711', 'display_name': 'Hongyun Zhao', 'orcid': 'https://orcid.org/0000-0002-2997-1762'}, 'institutions': [{'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hongyun Zhao', 'raw_affiliation_strings': ['1Rice Univ., Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1Rice Univ., Houston, TX;', 'institution_ids': ['https://openalex.org/I74775410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000830148', 'display_name': 'Juan C. Marini', 'orcid': 'https://orcid.org/0000-0002-1810-4479'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Juan C. Marini', 'raw_affiliation_strings': ['2Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': '2Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038715165', 'display_name': 'Deepak Nagrath', 'orcid': 'https://orcid.org/0000-0002-8999-2282'}, 'institutions': [{'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deepak Nagrath', 'raw_affiliation_strings': ['1Rice Univ., Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1Rice Univ., Houston, TX;', 'institution_ids': ['https://openalex.org/I74775410']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.113, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.506093, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 65, 'max': 72}, 'biblio': {'volume': '73', 'issue': '8_Supplement', 'first_page': '1892', 'last_page': '1892'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10836', 'display_name': 'Metabolomics and Mass Spectrometry Studies', 'score': 0.9706, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9583, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/metabolic-flux-analysis', 'display_name': 'Metabolic flux analysis', 'score': 0.79152346}, {'id': 'https://openalex.org/keywords/flux-balance-analysis', 'display_name': 'Flux Balance Analysis', 'score': 0.587121}, {'id': 'https://openalex.org/keywords/metabolic-pathway', 'display_name': 'Metabolic pathway', 'score': 0.5640021}, {'id': 'https://openalex.org/keywords/metabolic-network', 'display_name': 'Metabolic network', 'score': 0.5400892}, {'id': 'https://openalex.org/keywords/bioenergetics', 'display_name': 'Bioenergetics', 'score': 0.5068875}], 'concepts': [{'id': 'https://openalex.org/C2779349466', 'wikidata': 'https://www.wikidata.org/wiki/Q181619', 'display_name': 'Glutamine', 'level': 3, 'score': 0.83941644}, {'id': 'https://openalex.org/C160941953', 'wikidata': 'https://www.wikidata.org/wiki/Q6822342', 'display_name': 'Metabolic flux analysis', 'level': 3, 'score': 0.79152346}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.64601}, {'id': 'https://openalex.org/C68709404', 'wikidata': 'https://www.wikidata.org/wiki/Q1134475', 'display_name': 'Flux (metallurgy)', 'level': 2, 'score': 0.6063603}, {'id': 'https://openalex.org/C167091322', 'wikidata': 'https://www.wikidata.org/wiki/Q5463029', 'display_name': 'Flux balance analysis', 'level': 2, 'score': 0.587121}, {'id': 'https://openalex.org/C192989942', 'wikidata': 'https://www.wikidata.org/wiki/Q68685', 'display_name': 'Metabolic pathway', 'level': 3, 'score': 0.5640021}, {'id': 'https://openalex.org/C3409486', 'wikidata': 'https://www.wikidata.org/wiki/Q827489', 'display_name': 'Pentose phosphate pathway', 'level': 4, 'score': 0.5599728}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.54827744}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5455264}, {'id': 'https://openalex.org/C101810790', 'wikidata': 'https://www.wikidata.org/wiki/Q2263094', 'display_name': 'Metabolic network', 'level': 2, 'score': 0.5400892}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.52859664}, {'id': 'https://openalex.org/C100206155', 'wikidata': 'https://www.wikidata.org/wiki/Q570714', 'display_name': 'Bioenergetics', 'level': 3, 'score': 0.5068875}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48991817}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.44025397}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39107728}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32270044}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3171439}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.2357561}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.18756902}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07845616}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-1892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.46, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2350881169', 'https://openalex.org/W2341681417', 'https://openalex.org/W2133150343', 'https://openalex.org/W2113329733', 'https://openalex.org/W2070388085', 'https://openalex.org/W2047334633', 'https://openalex.org/W2018212195', 'https://openalex.org/W1999460937', 'https://openalex.org/W1984242440', 'https://openalex.org/W1983989854'], 'abstract_inverted_index': {'Abstract': [0], 'Cancer': [1, 336, 346], 'cell': [2, 20, 141], 'metabolism': [3, 213], 'was': [4, 356, 368], 'investigated': [5], 'using': [6, 203], 'systems': [7], 'biology': [8], 'tools': [9], 'such': [10], 'as': [11, 120, 216], 'metabolic': [12, 21, 33, 42, 73, 114, 154, 268, 314], 'flux': [13, 22, 43, 96, 310], 'analysis': [14, 44, 63, 98, 311], '(MFA)': [15], 'to': [16, 40, 45, 82, 136, 152, 208, 217, 221, 370], 'reveal': [17], 'intracellular': [18, 48, 58, 85, 105], 'cancer': [19, 36, 118, 140, 174, 199, 247, 258, 292, 321], 'distribution.': [23], 'To': [24], 'obtain': [25], 'a': [26, 52, 121, 149], 'complete': [27], 'role': [28], 'of': [29, 35, 57, 69, 104, 113, 123, 190, 198, 205, 253, 264, 277, 326, 331], 'nutrient-induced': [30], 'deprivation': [31, 129, 161], 'in': [32, 116, 246, 251, 291, 316], 'reprogramming': [34, 315], 'cells,': [37], 'we': [38, 88], 'need': [39], 'use': [41], 'determine': [46], 'unknown': [47], 'fluxes.': [49, 74, 86], 'MFA': [50, 75], 'provides': [51, 270], 'framework': [53, 101], 'for': [54, 139, 169, 195, 274, 335], 'the': [55, 66, 70, 84, 124, 191, 223, 227, 275, 283, 327, 332, 360, 366], 'estimation': [56, 103], 'fluxes': [59, 106], 'and': [60, 78, 95, 107, 111, 127, 132, 144, 159, 162, 171, 211, 231, 236, 244, 285, 309, 318], 'energy': [61, 93], 'balance': [62, 80, 94, 97], '(EBA)': [64], 'ensures': [65], 'thermodynamic': [67], 'feasibility': [68], 'computed': [71], 'optimal': [72], 'uses': [76], 'stoichiometric': [77], 'mass': [79], 'constraints': [81], 'compute': [83], 'Here,': [87], 'have': [89], 'developed': [90], 'an': [91, 271], 'integrated': [92], 'framework.': [99], 'Our': [100, 176, 201], 'allows': [102], 'reveals': [108, 312], 'specific': [109], 'adaptations': [110, 284], 'dysregulation': [112], 'pathways': [115, 219], 'ovarian': [117], 'cells': [119], 'result': [122], 'nutrient': [125], '(glucose': [126], 'glutamine)': [128], 'conditions.': [130], 'Glutamine': [131], 'glucose': [133, 158, 243], 'are': [134], 'known': [135], 'be': [137, 240], 'important': [138], 'survival,': [142], 'growth': [143], 'progression.': [145], 'Thus,': [146], 'there': [147], 'is': [148], 'strong': [150], 'motivation': [151], 'study': [153], 'alternations': [155], 'caused': [156], 'by': [157, 242, 288], 'glutamine': [160, 245], 'uncover': [163], 'links': [164], 'between': [165], 'various': [166, 289], 'fuel': [167], 'sources': [168], 'highly': [170, 317], 'less': [172, 319], 'invasive': [173, 320], 'cells.': [175, 200, 248, 322], 'findings': [177], 'indicate': [178], 'that': [179, 262, 280], 'NAD+/NADH': [180], 'ratio': [181], 'regulates': [182], "glutamine's": [183], 'direct': [184], 'effect': [185], 'on': [186], 'lactate': [187], 'production': [188], 'irrespective': [189], 'bioenergetic': [192], 'substrate': [193], 'requirement': [194], 'different': [196], 'kinds': [197], 'findings,': [202], 'quantification': [204], 'metabolites': [206], 'pertaining': [207], 'central': [209], 'carbon': [210], 'nitrogen': [212], 'provided': [214], 'clues': [215], 'which': [218, 256], 'relevant': [220], 'glycolysis,': [222], 'pentose': [224], 'phosphate': [225], 'pathway,': [226], 'TCA,': [228], 'urea': [229], 'cycles': [230], 'lipid': [232], 'cycles,': [233], 'amino': [234], 'acid': [235], 'nucleotide': [237], 'metabolisms': [238], 'may': [239], 'altered': [241], 'This': [249, 354], 'resulted': [250], 'identification': [252], 'dominant': [254], 'factors': [255], 'control': [257], 'metabolism.': [259, 293], 'We': [260], 'believe': [261], 'development': [263, 276], 'our': [265], 'oncosecretomics': [266], 'based': [267], 'strategy': [269], 'unprecedented': [272], 'opportunity': [273], 'nutritional': [278], 'supplementation': [279], 'can': [281], 'deregulate': [282], 'alterations': [286], 'induced': [287], 'nutrients': [290], 'Citation': [294], 'Format:': [295], 'Abhinav': [296], 'Achreja,': [297], 'Lifeng': [298], 'Yang,': [299], 'Hongyun': [300], 'Zhao,': [301], 'Juan': [302], 'C.': [303], 'Marini,': [304], 'Deepak': [305], 'Nagrath.': [306], 'Integrated': [307], 'energetics': [308], 'differential': [313], '[abstract].': [323], 'In:': [324], 'Proceedings': [325], '104th': [328], 'Annual': [329, 362], 'Meeting': [330, 363], 'American': [333], 'Association': [334], 'Research;': [337], '2013': [338, 364], 'Apr': [339], '6-10;': [340], 'Washington,': [341], 'DC.': [342], 'Philadelphia': [343], '(PA):': [344], 'AACR;': [345], 'Res': [347], '2013;73(8': [348], 'Suppl):Abstract': [349], 'nr': [350], '1892.': [351], 'doi:10.1158/1538-7445.AM2013-1892': [352], 'Note:': [353], 'abstract': [355], 'not': [357], 'presented': [358], 'at': [359], 'AACR': [361], 'because': [365], 'presenter': [367], 'unable': [369], 'attend.': [371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2316038256', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-08T13:07:15.853003', 'created_date': '2016-06-24'}