Publication Information

{'id': 'https://openalex.org/W1983989854', 'doi': 'https://doi.org/10.1042/bj20140984', 'title': 'Fluxes through plant metabolic networks: measurements, predictions, insights and challenges', 'display_name': 'Fluxes through plant metabolic networks: measurements, predictions, insights and challenges', 'publication_year': 2014, 'publication_date': '2014-12-12', 'ids': {'openalex': 'https://openalex.org/W1983989854', 'doi': 'https://doi.org/10.1042/bj20140984', 'mag': '1983989854', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25631681'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20140984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064104793', 'display_name': 'Nicholas J. Kruger', 'orcid': 'https://orcid.org/0000-0003-0492-3542'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Nicholas\xa0J. Kruger', 'raw_affiliation_strings': ['Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, U.K'], 'affiliations': [{'raw_affiliation_string': 'Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, U.K', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019754635', 'display_name': 'R. George Ratcliffe', 'orcid': 'https://orcid.org/0000-0001-8394-1575'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'R. George Ratcliffe', 'raw_affiliation_strings': ['Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, U.K'], 'affiliations': [{'raw_affiliation_string': 'Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, U.K', 'institution_ids': ['https://openalex.org/I40120149']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.609, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.593112, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '465', 'issue': '1', 'first_page': '27', 'last_page': '38'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10932', 'display_name': 'Microbial Metabolic Engineering and Bioproduction', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10932', 'display_name': 'Microbial Metabolic Engineering and Bioproduction', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10171', 'display_name': 'Biofuel production and bioconversion', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10404', 'display_name': 'Enzyme Catalysis and Immobilization', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flux-balance-analysis', 'display_name': 'Flux Balance Analysis', 'score': 0.8943757}, {'id': 'https://openalex.org/keywords/metabolic-network', 'display_name': 'Metabolic network', 'score': 0.8301096}, {'id': 'https://openalex.org/keywords/metabolic-flux-analysis', 'display_name': 'Metabolic flux analysis', 'score': 0.71750295}, {'id': 'https://openalex.org/keywords/plant-metabolism', 'display_name': 'Plant metabolism', 'score': 0.53097355}, {'id': 'https://openalex.org/keywords/scope', 'display_name': 'Scope (computer science)', 'score': 0.5288031}, {'id': 'https://openalex.org/keywords/network-analysis', 'display_name': 'Network Analysis', 'score': 0.4611175}], 'concepts': [{'id': 'https://openalex.org/C167091322', 'wikidata': 'https://www.wikidata.org/wiki/Q5463029', 'display_name': 'Flux balance analysis', 'level': 2, 'score': 0.8943757}, {'id': 'https://openalex.org/C101810790', 'wikidata': 'https://www.wikidata.org/wiki/Q2263094', 'display_name': 'Metabolic network', 'level': 2, 'score': 0.8301096}, {'id': 'https://openalex.org/C160941953', 'wikidata': 'https://www.wikidata.org/wiki/Q6822342', 'display_name': 'Metabolic flux analysis', 'level': 3, 'score': 0.71750295}, {'id': 'https://openalex.org/C14036430', 'wikidata': 'https://www.wikidata.org/wiki/Q3736076', 'display_name': 'Function (biology)', 'level': 2, 'score': 0.5824138}, {'id': 'https://openalex.org/C68709404', 'wikidata': 'https://www.wikidata.org/wiki/Q1134475', 'display_name': 'Flux (metallurgy)', 'level': 2, 'score': 0.5410155}, {'id': 'https://openalex.org/C2992992772', 'wikidata': 'https://www.wikidata.org/wiki/Q185973', 'display_name': 'Plant metabolism', 'level': 4, 'score': 0.53097355}, {'id': 'https://openalex.org/C2778012447', 'wikidata': 'https://www.wikidata.org/wiki/Q1034415', 'display_name': 'Scope (computer science)', 'level': 2, 'score': 0.5288031}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.48758787}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.48470807}, {'id': 'https://openalex.org/C32946077', 'wikidata': 'https://www.wikidata.org/wiki/Q618079', 'display_name': 'Network analysis', 'level': 2, 'score': 0.4611175}, {'id': 'https://openalex.org/C152662350', 'wikidata': 'https://www.wikidata.org/wiki/Q815297', 'display_name': 'Systems biology', 'level': 2, 'score': 0.42310488}, {'id': 'https://openalex.org/C186060115', 'wikidata': 'https://www.wikidata.org/wiki/Q30336093', 'display_name': 'Biological system', 'level': 1, 'score': 0.40805677}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.38015}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34090677}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.22833106}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.17152172}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.13825658}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13789141}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C119599485', 'wikidata': 'https://www.wikidata.org/wiki/Q43035', 'display_name': 'Electrical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D064688', 'descriptor_name': 'Metabolic Flux Analysis', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D053858', 'descriptor_name': 'Metabolic Networks and Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064688', 'descriptor_name': 'Metabolic Flux Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20140984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25631681', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/7', 'score': 0.66, 'display_name': 'Affordable and clean energy'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 125, 'referenced_works': ['https://openalex.org/W1576233366', 'https://openalex.org/W1767127367', 'https://openalex.org/W1838704976', 'https://openalex.org/W1867306340', 'https://openalex.org/W1963489914', 'https://openalex.org/W1963502995', 'https://openalex.org/W1966136694', 'https://openalex.org/W1967039865', 'https://openalex.org/W1968449541', 'https://openalex.org/W1970083563', 'https://openalex.org/W1972082139', 'https://openalex.org/W1973471708', 'https://openalex.org/W1979294707', 'https://openalex.org/W1983071204', 'https://openalex.org/W1984197456', 'https://openalex.org/W1984293417', 'https://openalex.org/W1990712597', 'https://openalex.org/W1991029581', 'https://openalex.org/W1997679574', 'https://openalex.org/W2001084806', 'https://openalex.org/W2001980128', 'https://openalex.org/W2006559324', 'https://openalex.org/W2007667792', 'https://openalex.org/W2007869849', 'https://openalex.org/W2011307711', 'https://openalex.org/W2012689220', 'https://openalex.org/W2013085592', 'https://openalex.org/W2014662834', 'https://openalex.org/W2015399172', 'https://openalex.org/W2015450099', 'https://openalex.org/W2015600749', 'https://openalex.org/W2018856264', 'https://openalex.org/W2020425795', 'https://openalex.org/W2020916135', 'https://openalex.org/W2024455490', 'https://openalex.org/W2030240805', 'https://openalex.org/W2030708049', 'https://openalex.org/W2030933109', 'https://openalex.org/W2031825920', 'https://openalex.org/W2032118099', 'https://openalex.org/W2032271434', 'https://openalex.org/W2037694688', 'https://openalex.org/W2038070550', 'https://openalex.org/W2040199573', 'https://openalex.org/W2042355755', 'https://openalex.org/W2044243244', 'https://openalex.org/W2045593084', 'https://openalex.org/W2050002062', 'https://openalex.org/W2050100306', 'https://openalex.org/W2051929959', 'https://openalex.org/W2055280476', 'https://openalex.org/W2057367356', 'https://openalex.org/W2058713700', 'https://openalex.org/W2059886764', 'https://openalex.org/W2063423537', 'https://openalex.org/W2063763893', 'https://openalex.org/W2070853125', 'https://openalex.org/W2076716065', 'https://openalex.org/W2078719811', 'https://openalex.org/W2081781433', 'https://openalex.org/W2082382448', 'https://openalex.org/W2085236271', 'https://openalex.org/W2089661821', 'https://openalex.org/W2090181847', 'https://openalex.org/W2095386536', 'https://openalex.org/W2095733998', 'https://openalex.org/W2099363748', 'https://openalex.org/W2099930788', 'https://openalex.org/W2100580624', 'https://openalex.org/W2101271542', 'https://openalex.org/W2101645389', 'https://openalex.org/W2102578493', 'https://openalex.org/W2103135236', 'https://openalex.org/W2104127415', 'https://openalex.org/W2104896732', 'https://openalex.org/W2108030459', 'https://openalex.org/W2109483080', 'https://openalex.org/W2109735732', 'https://openalex.org/W2110751375', 'https://openalex.org/W2111421616', 'https://openalex.org/W2111550864', 'https://openalex.org/W2111652881', 'https://openalex.org/W2112523029', 'https://openalex.org/W2119600524', 'https://openalex.org/W2119859261', 'https://openalex.org/W2121490038', 'https://openalex.org/W2121608972', 'https://openalex.org/W2126295585', 'https://openalex.org/W2127262798', 'https://openalex.org/W2128589452', 'https://openalex.org/W2128927770', 'https://openalex.org/W2132490111', 'https://openalex.org/W2133556195', 'https://openalex.org/W2133895954', 'https://openalex.org/W2134138595', 'https://openalex.org/W2137357811', 'https://openalex.org/W2137723667', 'https://openalex.org/W2137832374', 'https://openalex.org/W2140674401', 'https://openalex.org/W2141594771', 'https://openalex.org/W2142111857', 'https://openalex.org/W2142270568', 'https://openalex.org/W2145547605', 'https://openalex.org/W2147962989', 'https://openalex.org/W2148174909', 'https://openalex.org/W2148497594', 'https://openalex.org/W2149781053', 'https://openalex.org/W2150399741', 'https://openalex.org/W2151943426', 'https://openalex.org/W2153720780', 'https://openalex.org/W2154397036', 'https://openalex.org/W2156185846', 'https://openalex.org/W2158479704', 'https://openalex.org/W2162193054', 'https://openalex.org/W2163433435', 'https://openalex.org/W2169376598', 'https://openalex.org/W2169674481', 'https://openalex.org/W2170317108', 'https://openalex.org/W2170319684', 'https://openalex.org/W2171825851', 'https://openalex.org/W2171911221', 'https://openalex.org/W2419393762', 'https://openalex.org/W2436303151', 'https://openalex.org/W2476630621', 'https://openalex.org/W2502968364'], 'related_works': ['https://openalex.org/W3194611481', 'https://openalex.org/W3084362230', 'https://openalex.org/W2217120360', 'https://openalex.org/W2133150343', 'https://openalex.org/W2095386536', 'https://openalex.org/W2042444504', 'https://openalex.org/W2018212195', 'https://openalex.org/W1999460937', 'https://openalex.org/W1983785665', 'https://openalex.org/W1865302071'], 'abstract_inverted_index': {'Although': [0], 'the': [1, 22, 36, 44, 60, 65, 70, 81, 88, 119, 126, 134, 143, 161, 172, 201, 216, 229], 'flows': [2], 'of': [3, 24, 57, 67, 69, 93, 121, 138, 146, 160, 174, 188, 195, 203, 218, 231], 'material': [4], 'through': [5, 171], 'metabolic': [6, 94, 140, 169, 198], 'networks': [7, 170], 'are': [8, 14, 154, 221], 'central': [9, 84], 'to': [10, 17, 79, 99, 152], 'cell': [11, 209], 'function,': [12], 'they': [13, 129], 'not': [15], 'easy': [16], 'measure': [18], 'other': [19], 'than': [20], 'at': [21], 'level': [23], 'inputs': [25], 'and': [26, 42, 98, 148, 177, 200, 206, 223], 'outputs.': [27], 'This': [28], 'is': [29, 226], 'particularly': [30], 'true': [31], 'in': [32, 83], 'plant': [33, 139, 168, 189, 219], 'cells,': [34], 'where': [35, 43], 'network': [37, 45, 196], 'spans': [38], 'multiple': [39], 'subcellular': [40], 'compartments': [41], 'may': [46], 'function': [47], 'either': [48], 'heterotrophically': [49], 'or': [50], 'photoautotrophically.': [51], 'For': [52], 'many': [53], 'years,': [54], 'kinetic': [55], 'modelling': [56, 105], 'pathways': [58], 'provided': [59], 'only': [61], 'method': [62], 'for': [63, 118, 133, 208, 234], 'describing': [64], 'operation': [66], 'fragments': [68], 'network.': [71], 'However,': [72], 'more': [73, 135], 'recently,': [74], 'it': [75], 'has': [76, 191], 'become': [77], 'possible': [78], 'map': [80], 'fluxes': [82, 102], 'carbon': [85], 'metabolism': [86, 190], 'using': [87, 103], 'stable': [89], 'isotope': [90], 'labelling': [91], 'techniques': [92], 'flux': [95, 109], 'analysis': [96, 111, 120, 137], '(MFA),': [97], 'predict': [100], 'intracellular': [101], 'constraints-based': [104], 'procedures': [106], 'such': [107], 'as': [108, 150], 'balance': [110], '(FBA).': [112], 'These': [113], 'approaches': [114], 'were': [115], 'originally': [116], 'developed': [117], 'microbial': [122], 'metabolism,': [123], 'but': [124], 'over': [125], 'last': [127], 'decade,': [128], 'have': [130, 164], 'been': [131, 165], 'adapted': [132], 'demanding': [136], 'networks.': [141], 'Here,': [142], 'principal': [144], 'features': [145], 'MFA': [147, 220], 'FBA': [149], 'applied': [151], 'plants': [153], 'outlined,': [155], 'followed': [156], 'by': [157], 'a': [158, 185], 'discussion': [159, 181], 'insights': [162], 'that': [163, 214], 'gained': [166], 'into': [167], 'application': [173], 'these': [175], 'time-consuming': [176], 'non-trivial': [178], 'methods.': [179], 'The': [180], 'focuses': [182], 'on': [183, 228], 'how': [184], 'system-wide': [186], 'view': [187], 'increased': [192], 'our': [193], 'understanding': [194], 'structure,': [197], 'perturbations': [199], 'provision': [202], 'reducing': [204], 'power': [205], 'energy': [207], 'function.': [210], 'Current': [211], 'methodological': [212], 'challenges': [213], 'limit': [215], 'scope': [217], 'discussed': [222], 'particular': [224], 'emphasis': [225], 'placed': [227], 'importance': [230], 'developing': [232], 'methods': [233], 'cell-specific': [235], 'MFA.': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983989854', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}], 'updated_date': '2024-12-14T06:49:04.292022', 'created_date': '2016-06-24'}