Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2299746178', 'doi': 'https://doi.org/10.1016/j.arr.2016.02.009', 'title': 'Lysosomal cell death mechanisms in aging', 'display_name': 'Lysosomal cell death mechanisms in aging', 'publication_year': 2016, 'publication_date': '2016-12-01', 'ids': {'openalex': 'https://openalex.org/W2299746178', 'doi': 'https://doi.org/10.1016/j.arr.2016.02.009', 'mag': '2299746178', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26947122'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.arr.2016.02.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S117312820', 'display_name': 'Ageing Research Reviews', 'issn_l': '1568-1637', 'issn': ['1568-1637', '1872-9649'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://digital.csic.es/bitstream/10261/151084/1/ARR%202016.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048199372', 'display_name': 'Raquel Gómez‐Sintes', 'orcid': 'https://orcid.org/0000-0003-2854-6964'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Raquel Gómez-Sintes', 'raw_affiliation_strings': ['Department of Cellular and Molecular Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210147680']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081575554', 'display_name': 'María Dolores Ledesma', 'orcid': 'https://orcid.org/0000-0002-5679-6891'}, 'institutions': [{'id': 'https://openalex.org/I4210146061', 'display_name': 'Centro de Biología Molecular Severo Ochoa', 'ror': 'https://ror.org/03v9e8t09', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}, {'id': 'https://openalex.org/I63634437', 'display_name': 'Autonomous University of Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'María Dolores Ledesma', 'raw_affiliation_strings': ['Department of Molecular Neurobiology, Centro Biologia Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, 28049 Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Neurobiology, Centro Biologia Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, 28049 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210146061', 'https://openalex.org/I63634437']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5069533360', 'display_name': 'Patricia Boya', 'orcid': 'https://orcid.org/0000-0003-3045-951X'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Patricia Boya', 'raw_affiliation_strings': ['Department of Cellular and Molecular Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210147680']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5069533360'], 'corresponding_institution_ids': ['https://openalex.org/I4210147680'], 'apc_list': {'value': 4820, 'currency': 'USD', 'value_usd': 4820, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.316, 'has_fulltext': False, 'cited_by_count': 147, 'citation_normalized_percentile': {'value': 0.999498, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '32', 'issue': None, 'first_page': '150', 'last_page': '168'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders in Human Health and Disease', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/organelle', 'display_name': 'Organelle', 'score': 0.620545}, {'id': 'https://openalex.org/keywords/lysosomal-calcium-signaling', 'display_name': 'Lysosomal Calcium Signaling', 'score': 0.547917}, {'id': 'https://openalex.org/keywords/lysosomal-biogenesis', 'display_name': 'Lysosomal Biogenesis', 'score': 0.542458}, {'id': 'https://openalex.org/keywords/lysosomal-storage-disorders', 'display_name': 'Lysosomal Storage Disorders', 'score': 0.512088}, {'id': 'https://openalex.org/keywords/lysosomal-storage-diseases', 'display_name': 'Lysosomal Storage Diseases', 'score': 0.507866}, {'id': 'https://openalex.org/keywords/cell-damage', 'display_name': 'Cell damage', 'score': 0.4121283}], 'concepts': [{'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.79229045}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.7605968}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.7549856}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.7166344}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.70452535}, {'id': 'https://openalex.org/C167844969', 'wikidata': 'https://www.wikidata.org/wiki/Q426245', 'display_name': 'Cathepsin', 'level': 3, 'score': 0.65998125}, {'id': 'https://openalex.org/C168240541', 'wikidata': 'https://www.wikidata.org/wiki/Q45948', 'display_name': 'Organelle', 'level': 2, 'score': 0.620545}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.57596517}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5187436}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.47897363}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.45950577}, {'id': 'https://openalex.org/C2780369685', 'wikidata': 'https://www.wikidata.org/wiki/Q5058184', 'display_name': 'Cell damage', 'level': 2, 'score': 0.4121283}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3543685}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26171607}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.21975058}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.09828931}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07541734}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.068748474}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002403', 'descriptor_name': 'Cathepsins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002403', 'descriptor_name': 'Cathepsins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.arr.2016.02.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S117312820', 'display_name': 'Ageing Research Reviews', 'issn_l': '1568-1637', 'issn': ['1568-1637', '1872-9649'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10261/151084', 'pdf_url': 'https://digital.csic.es/bitstream/10261/151084/1/ARR%202016.pdf', 'source': {'id': 'https://openalex.org/S4306400616', 'display_name': 'DIGITAL.CSIC (Spanish National Research Council (CSIC))', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I134820265', 'host_organization_name': 'Consejo Superior de Investigaciones Científicas', 'host_organization_lineage': ['https://openalex.org/I134820265'], 'host_organization_lineage_names': ['Consejo Superior de Investigaciones Científicas'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26947122', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10261/151084', 'pdf_url': 'https://digital.csic.es/bitstream/10261/151084/1/ARR%202016.pdf', 'source': {'id': 'https://openalex.org/S4306400616', 'display_name': 'DIGITAL.CSIC (Spanish National Research Council (CSIC))', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I134820265', 'host_organization_name': 'Consejo Superior de Investigaciones Científicas', 'host_organization_lineage': ['https://openalex.org/I134820265'], 'host_organization_lineage_names': ['Consejo Superior de Investigaciones Científicas'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.79, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 218, 'referenced_works': ['https://openalex.org/W1142459305', 'https://openalex.org/W1169719024', 'https://openalex.org/W1491023851', 'https://openalex.org/W1491201714', 'https://openalex.org/W1518043112', 'https://openalex.org/W1538904872', 'https://openalex.org/W1551381188', 'https://openalex.org/W1576530886', 'https://openalex.org/W1670684017', 'https://openalex.org/W1676741814', 'https://openalex.org/W1691578538', 'https://openalex.org/W1771394546', 'https://openalex.org/W1791590074', 'https://openalex.org/W1803199265', 'https://openalex.org/W1878275597', 'https://openalex.org/W1907174433', 'https://openalex.org/W1926741639', 'https://openalex.org/W1964341586', 'https://openalex.org/W1967402588', 'https://openalex.org/W1969266303', 'https://openalex.org/W1970661950', 'https://openalex.org/W1972264725', 'https://openalex.org/W1972407541', 'https://openalex.org/W1973573196', 'https://openalex.org/W1975457949', 'https://openalex.org/W1975932268', 'https://openalex.org/W1978094485', 'https://openalex.org/W1978412530', 'https://openalex.org/W1978527995', 'https://openalex.org/W1979607272', 'https://openalex.org/W1980912292', 'https://openalex.org/W1982397114', 'https://openalex.org/W1984189188', 'https://openalex.org/W1985408391', 'https://openalex.org/W1987066016', 'https://openalex.org/W1988494097', 'https://openalex.org/W1989051519', 'https://openalex.org/W1990012982', 'https://openalex.org/W1990671250', 'https://openalex.org/W1993379925', 'https://openalex.org/W1993906893', 'https://openalex.org/W1994301968', 'https://openalex.org/W1996528337', 'https://openalex.org/W1997002066', 'https://openalex.org/W1998308437', 'https://openalex.org/W1999381390', 'https://openalex.org/W1999623170', 'https://openalex.org/W2000302106', 'https://openalex.org/W2000413234', 'https://openalex.org/W2000678720', 'https://openalex.org/W2006233042', 'https://openalex.org/W2006840724', 'https://openalex.org/W2009022140', 'https://openalex.org/W2009787733', 'https://openalex.org/W2012337697', 'https://openalex.org/W2013011614', 'https://openalex.org/W2017661157', 'https://openalex.org/W2017779665', 'https://openalex.org/W2019363409', 'https://openalex.org/W2021121989', 'https://openalex.org/W2022167776', 'https://openalex.org/W2022520367', 'https://openalex.org/W2022649483', 'https://openalex.org/W2023897774', 'https://openalex.org/W2024788934', 'https://openalex.org/W2027407745', 'https://openalex.org/W2027801751', 'https://openalex.org/W2029814386', 'https://openalex.org/W2030410023', 'https://openalex.org/W2030864103', 'https://openalex.org/W2031365272', 'https://openalex.org/W2034283361', 'https://openalex.org/W2035071395', 'https://openalex.org/W2035520103', 'https://openalex.org/W2036787961', 'https://openalex.org/W2037627674', 'https://openalex.org/W2038096193', 'https://openalex.org/W2038143181', 'https://openalex.org/W2040731722', 'https://openalex.org/W2041604269', 'https://openalex.org/W2041973584', 'https://openalex.org/W2042270105', 'https://openalex.org/W2043090568', 'https://openalex.org/W2043287922', 'https://openalex.org/W2043291430', 'https://openalex.org/W2043391367', 'https://openalex.org/W2044247344', 'https://openalex.org/W2044256586', 'https://openalex.org/W2044353844', 'https://openalex.org/W2045077644', 'https://openalex.org/W2045113104', 'https://openalex.org/W2045184673', 'https://openalex.org/W2046107966', 'https://openalex.org/W2046205790', 'https://openalex.org/W2046343047', 'https://openalex.org/W2047064554', 'https://openalex.org/W2047252395', 'https://openalex.org/W2048953882', 'https://openalex.org/W2049632022', 'https://openalex.org/W2051429808', 'https://openalex.org/W2052419480', 'https://openalex.org/W2052468549', 'https://openalex.org/W2052853635', 'https://openalex.org/W2053394933', 'https://openalex.org/W2054107351', 'https://openalex.org/W2055071444', 'https://openalex.org/W2056182070', 'https://openalex.org/W2057122453', 'https://openalex.org/W2058178546', 'https://openalex.org/W2058358730', 'https://openalex.org/W2058776369', 'https://openalex.org/W2059563381', 'https://openalex.org/W2060602529', 'https://openalex.org/W2062537454', 'https://openalex.org/W2064891909', 'https://openalex.org/W2065773869', 'https://openalex.org/W2065959664', 'https://openalex.org/W2067636508', 'https://openalex.org/W2068957253', 'https://openalex.org/W2069274491', 'https://openalex.org/W2069446662', 'https://openalex.org/W2070658923', 'https://openalex.org/W2071777978', 'https://openalex.org/W2073788301', 'https://openalex.org/W2075044628', 'https://openalex.org/W2076296181', 'https://openalex.org/W2076743021', 'https://openalex.org/W2077499130', 'https://openalex.org/W2078689358', 'https://openalex.org/W2079569342', 'https://openalex.org/W2080878773', 'https://openalex.org/W2082745411', 'https://openalex.org/W2084066460', 'https://openalex.org/W2084634452', 'https://openalex.org/W2084754412', 'https://openalex.org/W2084835703', 'https://openalex.org/W2087004359', 'https://openalex.org/W2088555531', 'https://openalex.org/W2089467829', 'https://openalex.org/W2089896660', 'https://openalex.org/W2089936534', 'https://openalex.org/W2090553671', 'https://openalex.org/W2090572041', 'https://openalex.org/W2096432058', 'https://openalex.org/W2097799342', 'https://openalex.org/W2099057738', 'https://openalex.org/W2099321680', 'https://openalex.org/W2101486712', 'https://openalex.org/W2101813663', 'https://openalex.org/W2103310968', 'https://openalex.org/W2104557299', 'https://openalex.org/W2104579415', 'https://openalex.org/W2107768418', 'https://openalex.org/W2108205327', 'https://openalex.org/W2108490599', 'https://openalex.org/W2108532688', 'https://openalex.org/W2111035539', 'https://openalex.org/W2112329697', 'https://openalex.org/W2115716807', 'https://openalex.org/W2116178196', 'https://openalex.org/W2118417727', 'https://openalex.org/W2118912353', 'https://openalex.org/W2123779560', 'https://openalex.org/W2124165909', 'https://openalex.org/W2126483755', 'https://openalex.org/W2127324182', 'https://openalex.org/W2127327360', 'https://openalex.org/W2131409532', 'https://openalex.org/W2134388096', 'https://openalex.org/W2134522616', 'https://openalex.org/W2135233980', 'https://openalex.org/W2135449612', 'https://openalex.org/W2135453787', 'https://openalex.org/W2135514753', 'https://openalex.org/W2136704793', 'https://openalex.org/W2137331743', 'https://openalex.org/W2138694950', 'https://openalex.org/W2140865453', 'https://openalex.org/W2142280970', 'https://openalex.org/W2142626890', 'https://openalex.org/W2143162047', 'https://openalex.org/W2146961420', 'https://openalex.org/W2149900898', 'https://openalex.org/W2150474659', 'https://openalex.org/W2151411140', 'https://openalex.org/W2151485460', 'https://openalex.org/W2152961389', 'https://openalex.org/W2153637944', 'https://openalex.org/W2153978486', 'https://openalex.org/W2154164675', 'https://openalex.org/W2154311364', 'https://openalex.org/W2155738133', 'https://openalex.org/W2156237697', 'https://openalex.org/W2156370464', 'https://openalex.org/W2157551652', 'https://openalex.org/W2157815025', 'https://openalex.org/W2157973824', 'https://openalex.org/W2158460113', 'https://openalex.org/W2159131006', 'https://openalex.org/W2159627505', 'https://openalex.org/W2160095658', 'https://openalex.org/W2160279897', 'https://openalex.org/W2161260889', 'https://openalex.org/W2162263320', 'https://openalex.org/W2163784507', 'https://openalex.org/W2164455918', 'https://openalex.org/W2166834236', 'https://openalex.org/W2168718279', 'https://openalex.org/W2180008421', 'https://openalex.org/W2465438133', 'https://openalex.org/W325483766', 'https://openalex.org/W4213174091', 'https://openalex.org/W4230792540', 'https://openalex.org/W4240361153', 'https://openalex.org/W4241864365', 'https://openalex.org/W4256213545', 'https://openalex.org/W46088057', 'https://openalex.org/W948426428'], 'related_works': ['https://openalex.org/W4312555957', 'https://openalex.org/W4286610787', 'https://openalex.org/W2794217300', 'https://openalex.org/W2764192351', 'https://openalex.org/W2582133925', 'https://openalex.org/W2415602131', 'https://openalex.org/W2326482042', 'https://openalex.org/W2245270938', 'https://openalex.org/W2057847205', 'https://openalex.org/W1990328562'], 'abstract_inverted_index': {'Lysosomes': [0], 'are': [1, 38], 'degradative': [2], 'organelles': [3], 'essential': [4], 'for': [5], 'cell': [6, 27, 115, 123], 'homeostasis': [7], 'that': [8, 80], 'regulate': [9], 'a': [10, 63], 'variety': [11], 'of': [12, 23, 35, 48, 93], 'processes,': [13], 'from': [14], 'calcium': [15], 'signaling': [16], 'and': [17, 52, 61, 74, 90, 113, 121, 129], 'nutrient': [18], 'responses': [19], 'to': [20, 71, 100, 117], 'autophagic': [21], 'degradation': [22], 'intracellular': [24, 72], 'components.': [25], 'Lysosomal': [26], 'death': [28], 'is': [29, 55], 'mediated': [30], 'by': [31, 86], 'the': [32, 41, 68, 88], 'lethal': [33], 'effects': [34], 'cathepsins,': [36], 'which': [37], 'released': [39], 'into': [40], 'cytoplasm': [42], 'following': [43], 'lysosomal': [44, 49, 84, 111, 118, 122], 'damage.': [45], 'This': [46], 'process': [47], 'membrane': [50, 119], 'permeabilization': [51, 120], 'cathepsin': [53], 'release': [54], 'observed': [56], 'in': [57, 65, 126], 'several': [58], 'physiopathological': [59], 'conditions': [60, 128], 'plays': [62], 'role': [64], 'tissue': [66], 'remodeling,': [67], 'immune': [69], 'response': [70], 'pathogens': [73], 'neurodegenerative': [75], 'diseases.': [76], 'Many': [77], 'evidences': [78], 'indicate': [79], 'aging': [81, 109], 'strongly': [82], 'influences': [83], 'activity': [85], 'altering': [87], 'physical': [89], 'chemical': [91], 'properties': [92], 'these': [94], 'organelles,': [95], 'rendering': [96], 'them': [97], 'more': [98], 'sensitive': [99], 'stress.': [101], 'In': [102], 'this': [103], 'review': [104], 'we': [105], 'focus': [106], 'on': [107], 'how': [108], 'alters': [110], 'function': [112], 'increases': [114], 'sensitivity': [116], 'death,': [124], 'both': [125], 'physiological': [127], 'age-related': [130], 'pathologies.': [131]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2299746178', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 22}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2024-09-13T11:55:04.760511', 'created_date': '2016-06-24'}